Effect of Tranilast Oily Gel on Carrageenin-Induced Granulation in Rats

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概要

• 論文の詳細を見る

• Tranilast (TL) oily gels consisting of hydrogenated soybean phospholipid and fatty- acid ester were prepared, and the inhibitory effect of the gels on the growth of granulation tissue were evaluated in a carrageenin-induced rat granulation model. By the application of 0.1 and 0.2% TL oily gel, the weight of granulation tissue was significantly reduced to 64 and 55%, respectively, of control value. Furthermore, these gels reduced their respective hydroxyproline content to 64 and 51% of the control. On the other hand, the inhibitory effect of 10% TL ointments, which are clinically used for the treatment of keloids and hypertrophic scars as hospital preparations, was much lower than that of the oily gels. In addition, the application of 0.1 and 0.2% oily gel led to high concentration (0.1% gel, 168±18 μg/g; 0.2% gel, 221±16 μg/g) of TL in the dermis as compared with the 10% TL ointments.These results suggest that TL oily gels may be a useful topical formulation for the treatment of keloids and hypertrophic scars.

• 公益社団法人日本薬学会の論文
• 2000-01-01

著者

• 齋藤 直樹

  Meiji Pharmaceutical University

• Matsumoto M

  Osaka Medical Center For Cancer And Cardiovascular Diseases Osaka

• Matsumoto Misako

  Department Of Immunology Osaka Medical Center For Cancer And Cardiovascular Diseases

• Fujii Makiko

  Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University

• Fujii M

  Department Of Pharmaceutics Showa College Of Pharmaceutical Sciences

• Fujii Makiko

  Department Of Chemistry Faculty Of Engineering Gifu University

• IKEGAMI KAZUHIKO

  Pharmaceutical Research Laboratories, Kissei Pharmaceutical Co., Ltd.

• MOMOSE DEN-ICHI

  Pharmaceutical Research Laboratories, Kissei Pharmaceutical Co., Ltd.

• Matsumoto Mitsuo

  Department of Pharmaceutics, Showa Pharmaceutical University

• SAITO Noriyasu

  Pharmaceutical Laboratories, Kissei Pharmaceutical Co., Ltd.,

• Fujii M

  Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University

• Matsumoto Mitsuharu

  Takeda Chemical Industries Ltd. Pharmaceutical Research Division

• Fukuoka Masamichi

  Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University

• Fukuoka Masamichi

  Division Of Medical Chemistry National Institute Of Hygienic Sciences

• Fujii M

  Showa Univ. Tokyo Jpn

• HORI Naohide

  Pharmaceutical Research Laboratories, Kissei Pharmaceutical Co., Ltd.,

• Saito Noriyasu

  Pharmaceutical Laboratories Kissei Pharmaceutical Co. Ltd.

• Matsumoto Mitsuo

  Department Of Pharmaceutics Showa Pharmaceutical University

• Momose Den-ichi

  Pharmaceutical Research Laboratories Kissei Pharmaceutical Co. Ltd.

• Hori N

  Pharmaceutical Research Laboratories Kissei Pharmaceutical Co. Ltd.

• Matsumoto Mitsuhiro

  First Department Of Internal Medicine Kumamoto University School Of Medicine

• HORI Noriyuki

  Kanebo Institute for Cancer Research, Kanebo, Ltd.,

• Matsumoto Mitsuo

  Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University

• Saito Norio

  Chemical Laboratory Meiji-gakuin University

• Ikegami Kazuhiko

  Pharmaceutical Research Laboratories Kissei Pharmaceutical Co. Ltd.

• Matsumoto Mitsuo

  Department Of Ophthalmology Hirosaki University School Of Medicine

• Matsumoto Mitsuo

  Department of Hydrocarbon Chemistry, Faculty of Engineering, Kyoto University

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