THREE-COMPARTMENT OPEN MODEL ANALYSIS OF MICRONOMICIN IN MAN
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概要
- 論文の詳細を見る
The pharmacokinetics of micronomicin (MCR) as a model drug of aminoglycoside antibiotics (AGs) was studied in man by applying our results previously obtained in rats. Three-compartment open model analysis of combined serum and total body store (T. B. S.) data obtained from multiple dosing in man was done using a non-linear least-squares regression program MULTI. We found large individual variations of MCR disposition in man and these variations did not appear within the serum cocentration range measurable with conventional assay methods. This finding suggests that the disposition of AGs, included MCR, cannot be estimated by only plasma or serum level analyses. We conclude that the therapeutic drug monitoring of AGs by using T. B. S. data analysis should be an effective method for controlling therapy with AGs in the clinical setting.
- 公益社団法人日本薬学会の論文
著者
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Matsumoto M
Osaka Medical Center For Cancer And Cardiovascular Diseases Osaka
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Matsumoto Misako
Department Of Immunology Osaka Medical Center For Cancer And Cardiovascular Diseases
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Matsumoto Mitsuharu
Takeda Chemical Industries Ltd. Pharmaceutical Research Division
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MATSUMOTO Mitsuo
Showa Pharmaceutical University
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Watanabe Makoto
School of Allied Medical Sciences, Kobe University
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KANENIWA NOBUYOSHI
School of Pharmaceutical Sciences, Showa University
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Mashimo Keimei
Department Of Internal Medicine Tokyo Kosei Nenkin Hospital
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Kaneniwa N
Showa Univ. Tokyo Jpn
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Kaneniwa Nobuyoshi
School Of Pharmaceutical Sciences Showa University
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Watanabe M
School Of Pharmaceutical Sciences Showa University:showa College Of Pharmaceutical Sciences Tokyo Ko
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Matsumoto Mitsuo
Showa College Of Pharmaceutical Sciences
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Kaneniwa Nobuyoshi
School Of Pharmaceutical Sciences Showa University:department Of Pharmacy Showa University Hospital
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Kaneniwa Nobuyoshi
Department Of Pharmacy Showa University Hospital:school Of Pharmaceutical Sciences Showa University
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Watanabe Makoto
School Of Allied Medical Sciences Kobe University
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