Pharmacodynamic Activity (Leukopoietic Effect) of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) after Rectal Administration in Rabbits with Leukopenia Induced by Cyclophosphamide
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概要
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The pharmacodynamic activity (leukopoietic effect) and pharmacokinetics of recombinant human granulocyte colony-stimulating factor (rhG-CSF) administered in various doses as hollow-type suppositories were investigated in rabbits with leukopenia induced by cyclophosphamide (CPA-treated rabbits). We found that serum granulocyte colony-stimulating factor (G-CSF) concentration was increased following the rectal administration of rhG-CSF. Therefore, rhG-CSF could be absorbed from the rectal mucosa in leukopenic rabbits who received CPA at a dose of 30 mg/kg/d. When rhG-CSF of at least 300 μg/kg was administered rectally once a day for 3 d in CPA-treated rabbits 1 d after the induction of leukopenia (the total count of leukocytes in peripheral blood [total blood leukocyte count] was below 5000/μl), decreased total blood leukocyte count returned to the normal physiological level and a maximum (7000-16000/μl) was obtained 3 d after the start of the rhG-CSF multiple-dosing regimen. We report for the first time that rhG-CSF administered rectally induces leukopoiesis in CPA-treated rabbits and reduces the period of leukopenia induced by CPA. Thus, the rhG-CSF hollow-type suppository offers a promising means of reducing the risk of leukopenia, an adverse side effect of CPA therapy.
- 公益社団法人日本薬学会の論文
- 1996-08-15
著者
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Matsumoto M
Osaka Medical Center For Cancer And Cardiovascular Diseases Osaka
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Matsumoto Misako
Department Of Immunology Osaka Medical Center For Cancer And Cardiovascular Diseases
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Watanabe Yoshiteru
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
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Matsumoto Mitsuo
Department of Pharmaceutics, Showa Pharmaceutical University
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Matsumoto Mitsuharu
Takeda Chemical Industries Ltd. Pharmaceutical Research Division
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Watanabe Yoshiteru
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Watanabe Y
Showa Pharmaceutical Univ.
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Kikuchi R
Faculty Of Pharmaceutical Sciences Kanazawa University
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菊地 利恵
Department Of Pharmaceutics Showa College Of Pharmaceutical Sciences
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Matsumoto Mitsuo
Department Of Pharmaceutics Showa Pharmaceutical University
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Watanabe Yoshiteru
Showa Pharmaceutical Univ.
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MIZUFUNE Yuko
Department of Pharmaceutics, Showa College of Pharmaceutical Sciences
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KIRIYAMA Miyuki
Department of Pharmaceutics, Showa College of Pharmaceutical Sciences
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OE Junko
Department of Pharmaceutics, Showa College of Pharmaceutical Sciences
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KIKUCHI Rie
Department of Pharmaceutics, Showa College of Pharmaceutical Sciences
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Matsumoto Mitsuhiro
First Department Of Internal Medicine Kumamoto University School Of Medicine
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Matsumoto Mitsuo
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Oe Junko
Department Of Pharmaceutics Showa College Of Pharmaceutical Sciences
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Mizufune Yuko
Department Of Pharmaceutics Showa College Of Pharmaceutical Sciences
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Kuriyama M
Department Of Pharmaceutics Showa College Of Pharmaceutical Sciences
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Matsumoto Mitsuo
Department Of Ophthalmology Hirosaki University School Of Medicine
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Matsumoto Mitsuo
Department of Hydrocarbon Chemistry, Faculty of Engineering, Kyoto University
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