A Novel Method for Predicting Disintegration Time in the Mouth of Rapidly Disintegrating Tablet by Compaction Analysis Using TabAll(Communication to the Editor)
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概要
- 論文の詳細を見る
A tableting process analyzer (TabAll) was used to predict disintegration time in the mouth of rapidly disintegrating tablet. Analyzer profiles recorded upper punch displacement and die wall force encountered during tablet processing. Changes in the mixing ratio of spherical sugar granules and microcrystalline cellulose or lactose affected upper punch displacement and die wall force profiles. Analysis of the compaction process revealed a strong association between disintegration time in the mouth and stationary time, relaxation time of upper punch displacement, and relaxation time of die wall force ; disintegration time in the mouth decreased as the three parameters increased. Thus, analysis of the compaction process is useful for predicting disintegration time in the mouth of rapidly disintegrating tablet, which can assist the formulation of new rapidly disintegrating tablets.
- 公益社団法人日本薬学会の論文
- 2004-11-01
著者
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近藤 昌夫
Graduate School Of Pharmaceutical Sciences Osaka University:department Of Pharmaceutics And Biopharm
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近藤 昌夫
Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Fujii Makiko
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
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Shibata Yusuke
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
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Watanabe Yoshiteru
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
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Fujii Makiko
Showa Pharmaceutical Univ.
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Fujii Makiko
Department Of Chemistry Faculty Of Engineering Gifu University
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KONDOH Masuo
Department of Biopharmaceutics and Pharmaceutics, Showa Pharmaceutical University
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YAMAMOTO Yoshihisa
Department of Physics, Tokyo Institute of Technology
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Kawase M
Research And Development Center Kobayashi Pharmaceutical Co. Ltd.
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Fujii M
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Kawase Masaya
Faculty Of Education Kagawa University
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Watanabe Yoshiteru
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Watanabe Y
Showa Pharmaceutical Univ.
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Shibata Yusuke
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Shibata Yusuke
Department Of Informatics Kyushu University:present Address Ntt Comware
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Fujii M
Showa Univ. Tokyo Jpn
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Watanabe Yoshiteru
Showa Pharmaceutical Univ.
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Yamamoto Y
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Yamamoto Yoshihisa
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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