Cytochrome C Release from Mitochondria Induced by Cadmium
スポンサーリンク
概要
- 論文の詳細を見る
Cadmium (Cd) induces apoptosis in vitro and in vivo. However, the mode of action is unclear. Cytochrome C (Cyt c) release from mitochondria into cytoplasm is a key event in apoptosis. In this study, we examined the effects of Cd on the release of Cyt c from mitochondria using human leukemia HL-60 cells and isolated mitochondria. Cd induced apoptosis in HL-60 cells in a dose-dependent manner, in accordance with increases in cytosolic Cyt c. Cd at 25 μM also induced the release of Cyt c from isolated mitochondria. Mitochondrial swelling induced by permeability transition is known to cause outer membrane rupture and Cyt c release from mitochondria. Cd induced a swelling of mitochondria in vitro, as did calcium, a classical inducer of mitochondrial permeability transition. These results suggest that apoptosis induced by Cd appears to be involved in a mitochondria-dependent pathway and in the release of Cyt c from mitochondria by swelling.
- 公益社団法人日本薬学会の論文
- 2001-02-01
著者
-
Sato Masao
Faculty of Pharmaceutical Science, Tokushima Bunri University
-
近藤 昌夫
Graduate School Of Pharmaceutical Sciences Osaka Univ.
-
Sato Masao
徳島文理大学 薬学部
-
HIGASHIMOTO Minoru
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
-
KONDOH Masuo
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
-
Sono M
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
-
Kondoh Masuo
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
-
Ogasawara Satoko
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
-
Araragi Saeko
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
-
Araragi Saeko
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
-
Ogasawara Satoko
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
-
Higashimoto Minoru
Faculty Of Pharmaceutical Sciences Tokushima Bunri University:faculty Of Food And Nutrition Suzugami
-
Sato Masao
Faculty Of Pharmaceutical Science Tokushima Bunri University
関連論文
- Possible involvement of arylhydrocarbon receptor variants in TCDD-induced thymic atrophy and XRE-dependent transcriptional activity in Wistar Hannover GALAS rats
- Involvement of Oxidative Stress in the Synthesis of Metallothionein Induced by Mitochondrial Inhibitors(Pharmacology)
- Morphological regulation and aggregate formation of rabbit chondrocytes on dendrimer-immobilized surfaces with D-glucose display(CELL AND TISSUE ENGINEERING)
- Glucose Transporter Mediation Responsible for Morphological Changes of Human Epithelial Cells on Glucose-Displayed Surfaces(CELL AND TISSUE ENGINEERING)
- Synergistic Effect of D-Glucose and Epidermal Growth Factor Display on Dynamic Behaviors of Human Epithelial Cells(CELL AND TISSUE ENGINEERING)
- Response of Human Epithelial Cells to Culture Surfaces with Varied Roughnesses Prepared by Immobilizing Dendrimers with/without D-Glucose Display(CELL AND TISSUE ENGINEERING)
- Availability of Bone Marrow Stromal Cells in Three-Dimensional Coculture with Hepatocytes and Transplantation into Liver-Damaged Mice(MEDICAL BIOTECHNOLOGY, Advances in Biomedical Science and Engineering)
- Maintenance of Hepatocyte Functions by Coculture with Bone Marrow Stromal Cells (MEDICAL BIOTECHNOLOGY)
- Dendrimer-Immobilized Culture Surface as a Tool to Evaluate Formation of Cellular Cytoskeleton of Anchorage-Dependent Cells (BIOCHEMICAL ENGINEERING)
- タイトジャンクション構成蛋白質Claudinを利用した新規薬物送達方法の構築
- A Norbergenin Derivative Inhibits Neuronal Cell Damage Induced by Tunicamycin(Molecular and Cell Biology)
- Induction of Hepatic Metallothionein by Mitochondrial Oxidative Stress in Mice
- Hepatoprotective Effect of Vitamin B_ on Dimethylnitrosamine-Induced Liver Injury(Pharmacology)
- Protection against D-Galactosamine-Induced Acute Liver Injury by Oral Administration of Extracts from Lentinus edodes Mycelia(Pharmacology)
- Suppression of Cell Death in Primary Rat Hepatocytes by α_1-Acid Glycoprotein(Cell and Tissue Engineering)
- Novel Function of Rare Catechin, Epigallocatechin-3-(3"-O-methyl)gallate, against Cold Injury in Primary Rat Hepatocytes(MISCELLANEOUS)
- Transplantation of Hepatocytes Cultured on Hydroxyapatite into Nagase Analbuminemia Rats (MEDICAL BIOTECHNOLOGY)
- Enhancing Effect of Zinc on Hepatoprotectivity of Epigallocatechin Gallate in Isolated Rat Hepatocytes
- Antioxidative Activity of (-)-Epigallocatechin-3-(3"-O-methyl) gallate Isolated from Fresh Tea Leaf and Preliminary Results on Its Biological Activity
- Effectiveness of Polyamidoamine Dendrimers Modified with Tripeptide Growth Factor, Glycyl-L-Histidyl-L-Lysine, for Enhancement of Function of Hepatoma Cells
- Immobilization of Tripeptide Growth Factor Glycyl-L-histidyl-L-lysine on Poly(vinylalcohol)-quarternized Stilbazole (PVA-SbQ) and Its Use as a Ligand for Hepatocyte Attachment
- Effectiveness of Fructose-Modified Chitosan as a Scaffold for Hepatocyte Attachment
- Effect of zinc on hepatoprotectivity of α1-acid glycoprotein
- Hepatoprotective Effect of Extracts from Lentinus edodes Mycelia on Dimethylnitrosamine-Induced Liver Injury(Pharmacology)
- Liver Protection by Bis (Maltolato) Zinc(II) Complex
- Growth Inhibition of Human Leukemia HL-60 Cells by an Antisense Phosphodiester Oligonucleotide Encapsulated into Fusogenic Liposomes
- Application of Glutaraldehyde-Crosslinked Chitosan as a Scaffold for Hepatocyte Attachment
- Inhibitory effects of herbal teas and herb extracts on the mutagenicity of 1-methy1-1, 2, 3, 4-tetrahydro-β-carboline-3-carboxylic acid upon treatment with nitrite in the presence of ethanol
- New ent-Kaurene-Type Diterpenoids Possessing Cytotoxicity from the New Zealand Liverwort Jungermannia Species
- A Novel Strategy for a Drug Delivery System Using a Claudin Modulator
- Efficient Gene Transfer into Differentiated Human Trophoblast Cells with Adenovirus Vector Containing RGD Motif in the Fiber Protein(Biopharmacy)
- Evaluation of the Compaction Properties of a Solid Dispersion of Indomethacin with Crospovidone by Tableting Process Analyzer
- Efficient Gene Transfer into Human Trophoblast Cells with Adenovirus Vector Containing Chimeric Type 5 and 35 Fiber Protein(Biopharmacy)
- A Novel Method for Predicting Disintegration Time in the Mouth of Rapidly Disintegrating Tablet by Compaction Analysis Using TabAll(Communication to the Editor)
- Cytotoxic and Apoptosis-Inducing ent-Kaurane-Type Diterpenoids from the Japanese Liverwort Jungermannia truncata NEES
- Involvement of Mesoderm-specific Transcript in Cell Growth of 3T3-L1 Preadipocytes
- Activation of Caspase-3 in HL-60 Cells Treated with Pyrithione and Zinc(Toxicology)
- Classical Conditioning of Metallothionein Synthesis in Mice
- Activation of a 36-kDa Myelin Basic Protein Kinase during Cadmium-Induced Apoptosis in Human Leukemia HL-60 Cells
- Cytochrome C Release from Mitochondria Induced by Cadmium
- Sesquiterpenoids Isolated from Eupatorium glehnii. Isolation of Guaiaglehnin A, Structure Revision of Hiyodorilactone B, and Genetic Comparison
- Induction of Metallothionein Synthesis by Cilostazol in Mice and in Human Cultured Neuronal Cell Lines(Molecular and Cell Biology)
- Hepatoprotective Effect of Syringic Acid and Vanillic Acid on CCl4-Induced Liver Injury
- Total Synthesis and Cytotoxicity of (+)- and (-)-Goniodiol and 6-epi-Goniodiol. Construction of α,β-Unsaturated Lactones by Ring-Closing Metathesis
- Preparation of Seven-Membered Carbocycles Using Ring-Closing Metathesis Reaction and Application to Syntheses of Tormesol and Cyathane Skeleton
- Seven Germacranolides, Eupaglehnins A, B, C, D, E, and F, and 2 α-Acetoxyepitulipinolide from Eupatorium glehni
- Samarium(II) Iodide-mediated Intramolecular Aldol-Type Cyclization
- Hepatoprotective Effect of Syringic Acid and Vanillic Acid on Concanavalin A-Induced Liver Injury
- Electrochemical Oxidation of α,β-Unsaturated Ketones
- Pigments from Uroleucon nigrotuberculatum Induce Apoptosis in HL60 Human Leukemia Cells, Implicating Intracellular Oxidative Stress and Activation of Caspases(Molecular and Cell Biology)
- Modulated Responses to Restraint Stress and Inflammation in Metallothionein-Null Mice
- Gene expression of mesoderm-specific transcript is upregulated as preadipocytes differentiate to adipocytes in vitro