Transplantation of Hepatocytes Cultured on Hydroxyapatite into Nagase Analbuminemia Rats (MEDICAL BIOTECHNOLOGY)
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概要
- 論文の詳細を見る
Rat hepatocytes were seeded in porous hydroxyapatite (HA) disks for hepatocyte transplantation to Nagase analbuminemic rat (NAR). To increase the cell density in the HA, cell suspension in the tube containing the disks were centrifuged down. The centrifugation increased the viable cell number in HA disk approximately 4-fold over the static method. The HA disks were intraperitoneally transplanted into NARs and harvested three weeks after the transplantation. Angiogenesis with no obvious inflammatory reaction was found inside the pore areas of HA. The ectopic transplantation well supported the viability of hepatocytes seeded in HA disks evidenced by significant increases in the host rats' serum albumin level as time passed after the transplantation.
- 社団法人日本生物工学会の論文
- 2003-07-25
著者
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近藤 昌夫
Graduate School Of Pharmaceutical Sciences Osaka University:department Of Pharmaceutics And Biopharm
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Kawase Masaya
Graduate School Of Pharmaceutical Sciences Osaka Univ.
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近藤 昌夫
Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Kawase Masaya
Nagahama Institute of Bio-science and Technology
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Yagi Kiyohito
Graduate School of Pharmaceutical Sciences, Osaka University
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Yagi K
Graduate School Of Pharmaceutical Sciences Osaka University
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Yagi Kiyohito
Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Yagi K
Osaka Univ. Osaka Jpn
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Kawase M
Nagahama Institute Of Bio-science And Technology
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Kawase M
Osaka Univ. Osaka Jpn
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Ohgushi Hajime
Research Institute For Cell Engineering National Institute Of Advanced Industrial And Technology
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Ohgushi Hajime
Tissue Engineering Research Group Research Institute For Cell Engineering (rice) National Institute
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Ohgushi Hajime
Tissue Engineering Research Center (terc) National Institute Of Advanced Industried Science And Tech
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Higashiyama Shinji
Graduate School Of Pharmaceutical Sciences Osaka University
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Kawase Masaya
Laboratory Of Industrial Biochemistry Department Of Industrial Chemistry Faculty Of Engineering Kyot
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NODA MEGUMI
Graduate School of Pharmaceutical Sciences, Osaka University
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MURAOKA SATOK
Graduate School of Pharmaceutical Sciences, Osaka University
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HIROSE MOTOHIRO
Tissue Engineering Research Center (TERC), National Institute of Advanced Industrial Science and Tec
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Yagi Kiyohito
Department Of Biocehmical Engineering Faculty Of Pharmaceutical Sciences Osaka University
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Kawase Mitsuo
Ngk Insulators Ltd.
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Kawase M
Research And Development Center Kobayashi Pharmaceutical Co. Ltd.
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Noda Megumi
Graduate School Of Pharmaceutical Sciences Osaka University
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Muraoka S
Graduate School Of Pharmaceutical Sciences Osaka University
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Ohgushi Hajime
Res. Inst. For Cell Engineering Aist 3-11-46 Nakoji Amagasaki Hyogo 6561-0974 Jpn
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Hirose Motohiro
Res. Inst. For Cell Engineering Aist 3-11-46 Nakoji Amagasaki Hyogo 6561-0974 Jpn
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Muraoka Satoko
Graduate School of Pharmaceutical Sciences, Osaka University
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