Hepatoprotective Effect of Vitamin B_<12> on Dimethylnitrosamine-Induced Liver Injury(Pharmacology)
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概要
- 論文の詳細を見る
Vitamin B_<12> contains a cobalt complex and accumulates at high levels in the liver. Vitamin B_<12> was examined for its hepatoprotective effect on dimethylnitrosamine-induced liver injury in mice. Vitamin B_<12> decreased the blood levels of aspartate aminotransferase and alanine aminotransferase, and clearly inhibited the overaccumulation of collagen fibrils. Reverse transcription-polymerase chain reaction (RT-PCR) analysis of the liver showed that the gene expression of α-smooth muscle actin and heat-shock protein 47, which are markers of fibrosis, were suppressed by vitamin B_<12> administration. Our findings indicate that vitamin B_<12> could be an effective hepatoprotective agent.
- 社団法人日本薬学会の論文
- 2008-02-01
著者
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近藤 昌夫
Graduate School Of Pharmaceutical Sciences Osaka University:department Of Pharmaceutics And Biopharm
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田谷 正仁
大阪大 大学院基礎工学研究科
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田谷 正仁
大阪大学大学院基礎工学研究科 化学系専攻
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HAYASHI Shinji
Graduate School of Science and Technology, Kobe University
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近藤 昌夫
Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Yagi Kiyohito
Graduate School of Pharmaceutical Sciences, Osaka University
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Yagi K
Graduate School Of Pharmaceutical Sciences Osaka University
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Yagi Kiyohito
Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Yagi K
Osaka Univ. Osaka Jpn
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Kawase M
Nagahama Institute Of Bio-science And Technology
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Kawase M
Osaka Univ. Osaka Jpn
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Taya Masahito
Div. Of Chemical Engineering Graduate School Of Engineering Sci. Osaka Univ. 1-3 Machikaneyama-cho T
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Taya M
Nagoya Univ. Nagoya Jpn
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Higashiyama Shinji
Graduate School Of Pharmaceutical Sciences Osaka University
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Watanabe A
Kobayashi Pharmaceutical Co. Ltd. Osaka Jpn
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Kawase Masaya
Faculty of Pharmaceutical Sciences, Osaka-ohtani University
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Isoda Katsuhiro
Graduate School of Pharmaceutical Sciences, Osaka University
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Hayashi Shinji
Graduate School Of Environment And Information Sciences Yokohama National University
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Taya Masahito
Department Of Chemical Science And Engineering Graduate School Of Engineering Science
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Taya Masahito
Department Of Chemical Engineering Faculty Of Engineerig Nagoya University
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KAGAYA Noritaka
Graduate School of Pharmaceutical Sciences, Osaka University
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AKAMATSU Soichiro
Graduate School of Pharmaceutical Sciences, Osaka University
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TAMESADA Makoto
Research and Development Center, Kobayashi Pharmaceutical Co., Ltd.
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WATANABE Aiko
Research and Development Center, Kobayashi Pharmaceutical Co., Ltd.
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KOBAYASHI Masakazu
Research and Development Center, Kobayashi Pharmaceutical Co., Ltd.
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TAGAWA Yoh-ichi
Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology Tokyo Instit
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KONDOH Masuo
Graduate School of Pharmaceutical Sciences, Osaka University
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AKAMATSU Soh-ichiro
Graduate School of Pharmaceutical Sciences, Osaka University
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Kagaya Noritaka
Graduate School Of Pharmaceutical Sciences Osaka University
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Tagawa Yoh-ichi
Department Of Biomolecular Engineering Graduate School Of Bioscience And Biotechnology Tokyo Institu
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Yagi Kiyohito
Department Of Biocehmical Engineering Faculty Of Pharmaceutical Sciences Osaka University
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Akamatsu Soichiro
Graduate School Of Pharmaceutical Sciences Osaka University
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Kawase M
Research And Development Center Kobayashi Pharmaceutical Co. Ltd.
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Kawase Masaya
Faculty Of Education Kagawa University
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Watanabe Aiko
Research And Development Center Kobayashi Pharmaceutical Co. Ltd.
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田谷 正仁
阪大院・基礎工:英文誌編集委員会:電子情報編集委員会
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Tamesada Makoto
Research And Development Center Kobayashi Pharmaceutical Co. Ltd.
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Kawase Masaya
Faculty Of Bioscience Nagahama Institute Of Bio-science And Technology
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