Synergic stimulation of laminin and epidermal growth factor facilitates the myoblast growth through promoting migration(CELL AND TISSUE ENGINEERING)
スポンサーリンク
概要
- 論文の詳細を見る
The dynamic behaviors of human skeletal muscle myoblasts were investigated in the culture on a laminin-coated surface in the presence of 100ng/ml epidermal growth factor (EGF) in medium. The coexistence of laminin and EGF caused the enhancement of myoblast migration, giving an average migration rate of 62.0μm/h, which was 2.7 times that on a plain surface. This encouraged migration could be a driving force to separate the dividing cells from each other, accompanied by shortened disjunction time of daughter cells to complete cytokinesis. In addition, the synergic effect of laminin and EGF led to the promotion of myoblast growth with keeping a relatively high fraction of proliferative cells during the culture for 150h, which is considered to arise from the reduced frequency of cell-cell contacts during cytokinesis and thereby suppressing the process towards myotube formation after cell division.
- 社団法人日本生物工学会の論文
著者
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Sawa Yoshiki
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine
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Sawa Yoshiki
Department Of Cardiovascular Surgery Osaka Graduate School Of Medicine
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紀ノ岡 正博
阪大院・工・生命先端
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CHOWDHURY Shiplu
Department of Biotechnology, Graduate School of Engineering, Osaka University
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MUNEYUKI Yuichi
Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University
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TAKEZAWA Yasunori
Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University
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SAITO Atsuhiro
Department of Surgery, Graduate School of Medicine, Osaka University
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TAYA Masahito
Department of Biotechnology, Graduate School of Engineering, Osaka University
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Sasako Yoshikado
Department Of Cardiovascular Surgery Osaka University
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Sawa Yoshiki
Department Of Surgery Division Of Cardiovascular Surgery Graduate School Of Medicine Osaka Universit
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田谷 正仁
大阪大 大学院基礎工学研究科
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田谷 正仁
大阪大学大学院基礎工学研究科 化学系専攻
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Kino-oka Masahiro
Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University
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紀ノ岡 正博
Dep. Of Biotechnology Graduate School Of Engineering Osaka Univ. 2-1 Yamadaoka Suita Osaka 565-0871
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Kinooka Masahiro
Department Of Biotechnology Graduate School Of Engineering Osaka University
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Kino-oka Masahiro
Grad. Sch. Eng. Sci. Osaka Univ.
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Syudo Yasuhiro
大阪大学 心臓血管外科
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Sato Yuichi
Department Of Imaging Health Park Clinic Kurosawa
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Saito Atsuhiro
Department Of Surgery Division Of Cardiovascular Surgery Graduate School Of Medicine Osaka Universit
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Saito Atsuhiro
Department Of Bio-medical Engineering Tokai University
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Takezawa Yasunori
Division Of Chemical Engineering Graduate School Of Engineering Science Osaka University
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Takezawa Yasunori
Division Of Biophysical Engineering Graduate School Of Engineering Science Osaka University
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Taya Masahito
Div. Of Chemical Engineering Graduate School Of Engineering Sci. Osaka Univ. 1-3 Machikaneyama-cho T
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Taya M
Nagoya Univ. Nagoya Jpn
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Taya Masahito
Division Of Chemical Engineering Department Of Materials Engineering Science Graduate School Of Engi
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Taya Masahito
Department Of Chemical Engineering Faculty Engineering Science Osaka University
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Taya Masahito
(present Address)faculty Of Engineering Science Osaka University
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CHOWDHURY Shiplu
阪大院・工・生命先端
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Chowdhury Shiplu
Department Of Biotechnology Graduate School Of Engineering Osaka University
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Sawada Yoshiko
Department Of Surgery Division Of Cardiovascular Surgery Graduate School Of Medicine Osaka Universit
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Shirakawa Yukitoshi
First Department Of Surgery Osaka University Medical School
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Maeda Yoshikatsu
Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University
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Muneyuki Yuichi
Division Of Chemical Engineering Graduate School Of Engineering Science Osaka University
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Taya Masahito
Department Of Chemical Science And Engineering Graduate School Of Engineering Science
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Taya Masahito
Division Of Chemical Engineering Department Of Materials Science Engineering Graduate School Of Engi
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Taya Masahito
Department Of Chemical Engineering Faculty Of Engineerig Nagoya University
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Suematsu Yoshihiro
Department of Cardiothoracic Surgery
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Kino-oka Masahiro
Division Of Chemical Engineering Department Of Biotechnology Graduate School Of Engineering Osaka Un
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Tamesada Makoto
Res. And Dev. Center Kobayashi Pharmaceutical Co. Ltd.
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Yokoyama Shinichiro
Department Of Cardiology Nihon University School Of Medicine
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Yokoyama Shin-ichiro
Second Department Of Internal Medicine Nihon University School Of Medicine
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Sakata Yasushi
Center For Advanced Medical Engineering And Informatics Osaka University
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Yashiki Shino
Division Of Chemical Engineering Graduate School Of Engineering Science Osaka University
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Taya Masahito
Department Of Biotechnology Graduate School Of Engineering Osaka University
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Suzuki Yasushi
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Sawa Yoshiki
Department Of Surgery Graduate School Of Medicine Osaka University
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田谷 正仁
阪大院・基礎工:英文誌編集委員会:電子情報編集委員会
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Shimazaki Yasuhisa
Department Of Radiology Ikeda City Hospital
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Shimazaki Y
Departments Of Surgery Yamagata University School Of Medicine
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Shimazaki Yasuhisa
2nd Department Of Surgery Yamagata University School Of Medicine
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Sawa Yoshiki
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Sawa Yoshiki
Division Of Cardiovascular Surgery Department Of Surgery Osaka University Graduate School Of Medicin
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Sawa Yoshiki
Department Of Cardiovascular Surgery
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Sawa Yoshiki
Division Of Cardiovascular Surgery Department Of Surgery Osaka University Graduate School Of Medicin
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Maeda Yoshikatsu
Division Of Chemical Engineering Graduate School Of Engineering Science Osaka University
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Shimazaki Yasuhisa
The First Department Of Surgery Osaka University Medical School
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Shimazaki Yasuhisa
大阪大学 第1外科
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RoyChowdhury Shiplu
Department of Biotechnology, Graduate School of Engineering, Osaka University
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