Restrictive Mitral Annuloplasty for Functional Mitral Regurgitation : – Acute Hemodynamics and Serial Echocardiography –
スポンサーリンク
概要
- 論文の詳細を見る
Background: Long-term effects of restrictive mitral annuloplasty (RMA), especially on hemodynamics and left ventricular (LV) function in patients with functional mitral regurgitation (MR), have not been fully investigated. Methods and Results: From 1999 to 2008, 44 patients with refractory heart failure and functional MR underwent RMA with stringent downsizing of the mitral annulus. Serial echocardiography was performed to evaluate LV function (reverse remodeling), estimated systolic pulmonary artery pressure (PAP) and mitral valve geometry at baseline and at discharge, and annually thereafter. Cardiac catheterization was performed at baseline, and at discharge to evaluate acute hemodynamic change. There were 3 early deaths, and the 5-year survival rate was 78±8%. In 41 survivors the clinical symptoms, stratified according to New York Heart Association class, significantly improved after surgery. Postoperative cardiac catheterization showed significant unloading for left ventricle, as well as improvement in LV systolic function. Serial echocardiography showed that improvements in LV function and systolic PAP were sustained in the majority of patients. Multivariate Cox regression analysis identified preoperative pulmonary hypertension (systolic PAP>60mmHg) as the significant predictor for postoperative adverse cardiac events. Conclusions: RMA for functional MR resulted in sustained improvement of hemodynamics and LV function over time. Additional studies are needed to define the negative impact of preoperative pulmonary hypertension in patients with this condition. (Circ J 2011; 75: 571-579)
著者
-
Sawa Yoshiki
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine
-
Funatsu Toshihiro
Department of Cardiology, National Cardiovascular Center
-
TODA Koichi
Department of Organ Transplantation, Cardiovascular Surgery, National Cardiovascular Center
-
Nishino Masami
Department Of Cardiology Kokura Memorial Hospital
-
TANIGUCHI Kazuhiro
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine
-
KAINUMA Satoshi
Department of Cardiovascular Surgery, Sakurabashi Watanabe Hospital
-
Kondoh Haruhiko
Department of Cardiovascular Surgery, Japan Labor Health and Welfare Organization, Osaka Rosai Hospi
-
Fujita Shin-ichi
Section of Clinical Echocardiography, Japan Labor Health and Welfare Organization, Osaka Rosai Hospi
関連論文
- Clinical Course and Outcome of Heart Transplant Recipients : Single Center Experience at the National Cardiovascular Center in Japan
- OE-294 A Functional Variation in a Gene Encoding One of Galectin-2 Binding Proteins Confers Risk of Myocardial Infarction in Asian Populations(OE50,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Oral Presentation (English),The 73rd A
- FRS-004 Large Scale SNPs Association Study to Identify Genes Confer Risk of Myocardial Infarction(FRS1,New Molecules for Cardiovascular Regulation (M),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Socie
- 4 Primary PCI versus CABG in Patients with Acute Myocardial Infarction due to the Occlusion of the Left Main Coronary Artery(Therapeutic Decision Making for Coronary Artery Disease Among PCI, CABG, and Medication,Symposium 3 (SY-03) (IHD),The 73rd Annual
- PJ-225 Lymphotoxin-alpha Regulates Monocyte Adhesion to Endothelial Cells by Up-regulation of Cell Adhesion Molecules via PI3K-Akt-NFkB Pathway in Human Endothelial Cells(Atherosclerosis, basic(06)(IHD),Poster Session(Japanese),The 72nd Annual Scientific
- FRS-097 Impact of Stented Segment Length on Long Term Result of Sirolimus Eluting Stent Implantation(FRS20,Clinical Evidence of DES Era (2) (IHD),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 1 Three-Year Outcome of the PRospective Evaluation of VENtricular Tachyarrhythmic Events and Sudden Cardiac Death in Patients with Left Ventricular Dysfunction (PREVENT-SCD) Study(Late Breaking Clinical Trials I,The 73rd Annual Scientific Meeting of The J
- Growth and differentiation potentials in confluent state of culture of human skeletal muscle myoblasts(CELL AND TISSUE ENGINEERING)
- Myogenic induction of human mesenchymal stem cells by culture on dendrimer-immobilized surface with D-glucose display(CELL AND TISSUE ENGINEERING)
- FRS-095 Impact of Hyperuricemia and Renal Dysfunction on Cardiovascular Events after the Onset of Acute Myocardial Infarction(Renal Dysfunction and Cardiovascular Disease(H),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circ
- Growth and differentiation potentials in confluent state of culture of human skeletal muscle myoblasts
- 2 Present Strategy for the Treatment of Profound Heart Failure : Long-term Support by Left Ventricular Assist Systems and Heart Transplantation(Therapeutic Strategy for Severe Heart Failure-From LVAD to Heart Transplantation-,Symposium 11 (SY-11) (H),The
- OE-352 The Preoperative Cardio-Renal-Anemia-Syndrome and Myocardial Fibrosis Have Negative Impact on Survival and Myocardial Recovery After Left Ventricular Assist Device Implantation(Heart failure, clinical(04)(M),Oral Presentation(English),The 72nd Annu
- Hemodynamic and Echocardiographic Evaluation of Orthotopic Heart Transplantation With the Modified Bicaval Anastomosis Technique
- 2 Present Strategy for the Treatment of Profound Heart Failure : Long-term Support by Left Ventricular Assist Systems and Heart Transplantation(Therapeutic Strategy for Severe Heart Failure-From LVAD to Heart Transplantation-,Symposium 11 (SY-11) (H),The
- OE-352 The Preoperative Cardio-Renal-Anemia-Syndrome and Myocardial Fibrosis Have Negative Impact on Survival and Myocardial Recovery After Left Ventricular Assist Device Implantation(Heart failure, clinical(04)(M),Oral Presentation(English),The 72nd Annu
- 3 Potential for Destination Therapy with Next Generation Left Ventricular Assist System (LVAS)(Impacts of latest developments of artificial organs/systems in the treatment of cardiovascular diseases,Topic 5 (TP-5) (IHD),Special Program,The 72nd Annual Sci
- 4 Cardiac rehabilitation in the management of patients with end-stage heart failure(Symposium 16 (SY-16) (H) Cardiac Rehabilitation : Innovative Approach to Improve Patient Care,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulatio
- 4 Long-term Use of Left Ventricular Assist System as a Bridge to Heart Transplant : Superior Survival Rate to REMATCH Trial(Symposium 8 (SY-08) (M) New Strategies for Management of Severe Heart Failure with New Devices and Surgery,Special Program,The 72nd
- OE-286 Which Factors Predict the Recovery of Natural Heart Function after Left Ventricular Assist System Insertion(Transplantation/LVAD-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-392 Progranulin Expression in Advanced Human Atherosclerotic Plaque(OE66,Atherosclerosis (Clinical/Pathophysiology) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-281 The Impact of Response to Cardiac Resynchronization Therapy on Ventricular Arrhythmic Events(OE48,CRT (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Exercise echocardiography in the evaluation of severity of functional mitral regurgitation in patients with heart failure
- 3 Hybrid Endovascular Repair for Aortic Arch Aneurysms(Current Status and Future Prospective of Stent-gratting for Aortic Aneurysm,Meet the Expert 7 (ME-7) (H),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Efficacy of Abciximab for Patients Undergoing Balloon Angioplasty : Data From Japanese Evaluation of c7E3 Fab for Elective and Primary PCI Organization in Randomized Trial (JEPPORT)(Ischemic Heart Disease)
- Bilateral lung transplantation with closure of ventricular septal defect in a patient with Eisenmenger syndrome
- Impact of surgical ventricular reconstruction for ischemic dilated cardiomyopathy on restrictive filling pattern
- Transdifferentiation of human adipose tissue-derived stromal cells into insulin-producing clusters
- Percutaneous Cardiopulmonary Support after Acute Myocardial Infarction at the Left Main Trunk
- PJ-786 Stable Delivery and Long-Term Survival of Sheet-Shaped Skeletal Myoblast in Infarct Myocardium(PJ132,Heart Failure, Basic (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-321 Assessment of Local Myocardial Stress and Function in Ischemic Cardiomyopathy : New Method Using Multidetector Computed Tomography and Novel Software System(PE054,CT/MRI (New Technology) (I),Poster Session (English),The 73rd Annual Scientific Meeti
- Synergic stimulation of laminin and epidermal growth factor facilitates the myoblast growth through promoting migration(CELL AND TISSUE ENGINEERING)
- OJ-155 Assessment of Regional Myocardial Stress before and after Restrictive Mitral Annuloplasty for Dilated Cardiomyopathy with Novel Software System(OJ26,Cardiac Function (Clinical) (M),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of
- 1 Management of Associated Regions in Grown-up Congenital Heart Disease Patients(Patient Menagement System for Adult Congenital Heart Disease,Symposium 19 (SY-19) (M),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 7 Next Generation LVAS as a Feasible Alternative to Heart Transplantation(Therapeutic Strategy for Severe Heart Failure-From LVAD to Heart Transplantation-,Symposium 11 (SY-11) (H),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 6 Treatment Strategies Involving Endovascular Repair of Aortic Aneurysms(Recent Progress in Diagnosis and Treatment of Aortic Diseases,Symposium 5 (SY-05) (A),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 4 Implantable LVAS as Long-term out of Hospital Management(Ventricular Assist Device: An Update,Topic 6 (TP-6) (IHD),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Restrictive Mitral Annuloplasty for Functional Mitral Regurgitation : – Acute Hemodynamics and Serial Echocardiography –
- 4 Autologous Cell Therapy in Combination with LVAS : A Possible Strategy for Bridge to Recovery in Patients with Severe Cardiomyopathy(Symposium 12 (SY-12) (M) Clinical Experiences of Regenerative Medicine in Cardiovascular Diseases,Special Program,The 72
- Participation of Caspase-3-Like Protease in Necrotic Cell Death of Myocardium During Ischemia-Reperfusion Injury in Rat Hearts
- PE-193 Three-years Experience of Transvenous Pacemaker Lead Removals Using Electrosurgical Dissection System (EDS)(PE033,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 3 (A),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Ci
- PJ-261 Impact of Insulin Resistance for Plaque Vulnerability in Patients with Coronary Artery Disease and without Known Diabetes(PJ044,Atherosclerosis (Clinical/Diagnosis) 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanes
- PJ-238 1-year Clinical Outcomes of Cardiac Resynchronization Therapy with Defibrillator in Single Center Experience(PJ040,CRT/ICD 2 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-397 Impact of Polyunsaturated Fatty Acids (PUFAs) on Positive Remodeling of Coronary Plaques : A Study with 64 Low MDCT (Multi-detector Computed Tomography)(PE067,Lipid Disorders 1 (H),Poster Session (English),The 73rd Annual Scientific Meeting of the
- OE-421 Incidence and Predictors of Appropriate Therapy in Patients Implanted ICD for Primary Prevention of Sudden Cardiac Death(OE71,ICD (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Severely Calcified Constrictive Pericarditis Simulating a Mediastinal Tumor and Obstructing the Right Ventricular Inflow Tract
- PJ-471 Clinical Efficacy of Patients after Femoropopliteal Stenting(PJ079,Peripheral Circulation/Vascular Disease (Therapy) 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-170 Impact of Hemodynamic State in Mild Hypothermia Therapy after Cardiac Arrest(PE029,Cardiopulmonary and Critical Care/ACLS (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- DPJ-023 Clinical Efficacy of Intrathoracic Impedance Monitoring System in Patients with Chronic Heart Failure(DPJ04,Heart Failure (Diagnosis) (M),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Immunological function of thymoma and pathogenesis of paraneoplastic myasthenia gravis
- Coexpression of Platelet-Derived Growth Factor Receptor Alpha and Fetal Liver Kinase 1 Enhances Cardiogenic Potential in Embryonic Stem Cell Differentiation In Vitro(CELL AND TISSUE ENGINEERING)
- Preprocedural Statin Administration can Reduce Thrombotic Reaction After Stent Implantation
- PE-197 Japanese Pilot Study: Preliminary Results for the CareLink^ Network : Medtronic Innovative Remote Monitoring System for Cardiac Pacing Devices(PE033,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 3 (A),Poster Session (English),The 73rd Annua
- Hypoxia/Reoxygenation in Cultured Neonatal Rat Ventricular Myocytes Induced Necrosis and Gene Analysis of Screening from Survival Cells(Myocardial Ischemia-reperfusion, Basic 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-600 Clinical Impact of Coronary Arterial Disease of Patients with Intermittent Claudication Undergoing Elective Endovascular Therapy(PJ101,Peripheral Circulation/Vascular Disease (Therapy) 3 (H),Poster Session (Japanese),The 73rd Annual Scientific Meet
- PJ-553 Catheter Ablation of Ventricular Tachycardia in Patients with Severely Impaired LV Function(PJ093,Ventricular Arrhythmia (Clinical/Diagnosis/Treatment) 2 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation S
- PJ-552 Catheter Ablation of Ventricular Tachycardia Associated with Structural Heart Disease : Comparison between Ischemic and Non-ischemic Heart Disease(PJ093,Ventricular Arrhythmia (Clinical/Diagnosis/Treatment) 2 (A),Poster Session (Japanese),The 73rd
- PJ-551 Catheter Ablation for the Treatment of Electrical Storm in Patients with Implantable Cardioverter-defibrillators (ICD)(PJ093,Ventricular Arrhythmia (Clinical/Diagnosis/Treatment) 2 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of
- PJ-467 Clinical Efficacy of Endovascular Therapy for Aorto-iliac Artery Occlusion(PJ079,Peripheral Circulation/Vascular Disease (Therapy) 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-203 Prevalence of Peripheral Arterial Disease in Patients with Coronary Artery Disease Undergoing Coronary Intervention(PJ034,Stress-psychosomatic Medicine (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Soc
- PE-487 Clinical and Electophysiological Characteristics of Repetitive Ventricular Fibrillations in Subacute Phase of Ischemic Heart Disease(PE082,Ventricular Arrhythmia (Clinical/Diagnosis/Treatment) (A),Poster Session (English),The 73rd Annual Scientific
- Progression of Left Coronary Artery Dissection during and after Aortic Replacement in Acute Type A Aortic Dissection : A Case Report
- OJ-510 Tissue Implantation of Myoblast Sheets Improve Cardiac Performance with Attenuation of Cardiac Remodeling in Dilated Cardiomyopathic Hamsters(Cardiomyopathy, Basic (M) : OJ62)(Oral Presentation (Japanese))
- Effect of high-frequency jet ventilation on oxygenation during one-lung ventilation in patients undergoing thoracic aneurysm surgery
- OJ-520 Cardiomyogenesis of multipotent stem cells from synovial membrane transplanted in rat infarcted myocardium : A new candidate for autologous cellular cardiomyoplasty(Molecular Biology, Myocardium 2 (M) : OJ64)(Oral Presentation (Japanese))
- Large Vessel-Sternum Adhesion After Cardiac Surgery ; A Risk-Factor Analysis
- Paraplegia and Paraparesis after Descending Thoracic Aortic Aneurysm Repair : A Risk Factor Analysis
- Subdural Hematoma Induced by Cerebrospinal Fluid Drainage : Potentially Catastrophic Complication of Spinal Cord Protection after Thoracoabdominal Aneurysm Repair
- Delayed Chronic Type A Dissection with a Functional Midline Crossing Right Internal Thoracic Artery after CABG : Surgical Approach to an Ascending Aorta without Dissecting the Midline Crossing Internal Thoracic Artery
- Percutaneous Cardiopulmonary Support With Heparin-Coated Circuits in Postcardiotomy Cardiogenic Shock, Efficacy and Comparison With Left Heart Bypass
- 3 Myocardial Regeneration Therapy Using Autologous Cell Sheet(Plenary Session 6 (PL-6) (M) Recent Update in Myocardial Regeneration : The Present Status and the Future Directions,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulati
- PE-040 Impaired utility of long chain fatty acid and mutations in the adipose triglyceride lipase gene in lipid storage cardiomyopathy(Cardiomyopathy, basic/clinical(03)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circula
- Early Experience of Aortic Valve Replacement With the Freestyle Stentless Aortic Bioprosthesis in Elderly Patients
- PJ-082 Assessment of Left Atrial Transport Function after the Maze Procedure Using Magnetic Resonance Imaging(Cardiac function, basic/clinical-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Minimally-Diluted Blood Cardioplegia Supplemented With Potassium and Magnesium for Combination of 'Initial, Continuous and Intermittent Bolus' Administration
- OE-075 A Novel Stress Protein, ORP-150/HSP12A Attenuates Myocardial Hypoxia-reoxygenation Injury in Rat Heart : A Promising Role of ORP-150 in Myocardial Protection(Myocardial Ischemia-Reperfusion, Basic and Clinical 1 (IHD) : OE10)(Oral Presentation (Eng
- 6 Myocardial regeneration therapy using autologous cells for the impaired myocardium : A novel strategy for the clinical trial(Symposium 8 (SY8) (M) : Regeneration Medicine of Cardiovascular Diseases)(Special Program)
- PJ-373 Five-year Echocardiographic Results of Restrictive Mitral Annuloplasty in Patients with Functional Mitral Regurgitation(PJ063,Heart Failure (Treatment) 1 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation S
- OE-407 Total Arterial Revascularization without Cardiopulmonary Bypass : Impact of Flow Competition on Arterial Grafts(Cardiovascular surgery/CABG(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- 1 Extensive Arch Aneurysms Repair with Long Elephant Trunk : Medium Term Follow Up of 69 Cases(Symposium 4 (SY-04) (H) Recent Progress in the Treatment of Aortic Diseases,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Socie
- In vivo Gene transfection with hepatocyte growth factor via pulmonary artery induces angiogenesis in rat lung
- Clinical and pathological aspects of thymic epithelial tumors
- Cardiopulmonary co-morbidity : a critical negative prognostic predictor for pulmonary resection following preoperative chemotherapy and/or radiation therapy in lung cancer patients
- Circulating tumor cells in peripheral blood caused by surgical manipulation of non-small-cell lung cancer : pilot study using an immunocytology method
- Right Heart Failure Secondary to Valvular Heart Disease : Surgical Strategies Depending on the Preoperative Assessment of Congestive Liver Dysfunction(Diagnosis and Treatment of Valvular Heart Disease-Multidiciplinary Treatment of the Patients who Suffer
- 5 Promising strategy of angiogenesis and regenaration therapy with bioengineered myoblast sheets and nets implantation : Preclinical trial for ischemic cardiomyopathy(Angiogenesis-Clinical and Experimental New Findings,Symposium 3 (SY3) (H),The 70th Anniv
- Impact of Myoblast Sheet Implantation for Myocardial Regeneratin in Dilated Cardiomyopathic Hamster : Effective Delivery of Myoblasts and Hepatocyte Growth Factor (Cardiac Hypertrophy/Cardiomyopathy 2 (M), The 69th Annual Scientific Meeting of the Japanes
- A Tissue Engineered Myoblast Sheet Improves Cardiac Performance
- 3 Usefulness of RV Function Assessment Using MRI in Patients Long Term after Definitive Repair for Congenital Heart Disease(Recent Advances in Imaging Modalities in Patients with Congenital Heart Disease and Kawasaki Disease, The 71st Annual Scientific Me
- An enhanced risk-group stratification system for more practical prognostication of clinically malignant gastrointestinal stromal tumors
- Application of Implantable Left Ventricular Assist System to the End-Stage Heart Failure
- Current and Future Perspectives of Minimally Invasive Open Heart Surgery
- PE-473 BH-4 Peptide Derivative from Bcl2 Attenuates Ischemia/reperfusion Injury Through Anti-apoptotic Mechanism in Rat Heart(Myocardial Ischemia-Reperfusion, Basic (M) : PE80)(Poster Session (English))
- Successful Surgical Intervention for Active Infective Endocarditis on a Hemodialysis Patient with Cerebral Infarction and Disseminated Intravascular Coagulopathy
- Gene Transfer of Hepatocyte Growth Factor via the Pulmonary Artery Induces Pulmonary Vascular Regeneration in Monocrotaline Treated Rats
- Improved long-term performance of pulsatile extracorporeal left ventricular assist device
- Rapid expansion of another downstream aortic aneurysm with the elephant trunk
- Restrictive Mitral Annuloplasty for Functional Mitral Regurgitation : Acute Hemodynamics and Serial Echocardiography
- Early Experiences of Transcatheter Aortic Valve Replacement in Japan
- The utility of echocardiographic evaluation of donor hearts upon the organ procurement for heart transplantation