Relationship Between Thin Cap Fibroatheroma Identified by Virtual Histology and Angioscopic Yellow Plaque in Quantitative Analysis With Colorimetry(Imaging)

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Background: Thin cap fibroatheroma (TCFA) is considered to be a vulnerable plaque. Virtual Histology-intravascular ultrasound (VH-IVUS) can precisely identify TCFA in vivo. Intense yellow plaque on angioscopy determined by quantitative colorimetry with L^*a^*b^* color space corresponds with histological TCFA; in particular, a plaque of color b^* value>23 indicates an atheroma with a fibrous cap thickness<100μm. In the present study, the relationship between VH-TCFA and angioscopic plaque color determined by colorimetry was investigated. Methods and Results: Fifty-seven culprit plaques in 57 patients were evaluated by VH-IVUS and angioscopy. VH-TCFA was defined as a plaque with a necrotic core>10% of plaque area without overlying fibrous tissue, and angioscopic TCFA was a plaque with b^* value>23. The frequency of angioscopic TCFA was higher in the VH-TCFA group than in the VH-non-TCFA group (74% vs 23%, P=0.0002). Moreover, yellow color intensity (b value) significantly correlated with plaque classification on VH-IVUS. When TCFA detected with angioscopy was used as the gold standard, the sensitivity, specificity, and accuracy for TCFA with VH-IVUS was 68%, 81%, and 75%, respectively. Conclusions: VH-TCFA strongly correlated with angioscopic TCFA determined by a quantitative analysis with colorimetry.
社団法人日本循環器学会の論文
2009-02-20