Evaluation of the Compaction Properties of a Solid Dispersion of Indomethacin with Crospovidone by Tableting Process Analyzer
スポンサーリンク
概要
- 論文の詳細を見る
A powder solid dispersion system (SD) of indomethacin (IM) with crospovidone (CrosPVP) possesses good fluidity and can be used for tablet formulation. Tablets of SD can be prepared by direct compression and have adequate hardness and a small variation in weight. Forces during the tableting process were measured with a tableting process analyzer (TabAll) equipped with a single-punch. The pressure transmission ratio (PTR) from the upper to the lower punch and the die wall force (DWF) were examined during the tableting process. Ejection force (EF) and scraper pressure (SP) were measured for determining the capping and sticking properties during the tableting process. Adding 1% magnesium stearate (MS) to the SD resulted in high PTR and DWF values and a low EF value. PTR and DWF values increased and EF value decreased when MS and microcrystalline cellulose (MCC) were added to the SD. A thousand tablets could be manufactured without problems such as sticking or capping when 1% MS and 50% MCC were added to the SD containing 25% IM.
- 公益社団法人日本薬学会の論文
- 2005-07-01
著者
-
WATANABE Yoshiteru
Showa Pharmaceutical University
-
FUJII Makiko
Showa Pharmaceutical University
-
近藤 昌夫
Graduate School Of Pharmaceutical Sciences Osaka University:department Of Pharmaceutics And Biopharm
-
近藤 昌夫
Graduate School Of Pharmaceutical Sciences Osaka Univ.
-
Fujii Makiko
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
-
Fujii Makiko
Showa Pharmaceutical Univ.
-
Fujii Makiko
Showa College Of Pharmaceutical Sciences
-
Kawase M
Research And Development Center Kobayashi Pharmaceutical Co. Ltd.
-
Fujii M
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
-
Kawase Masaya
Faculty Of Education Kagawa University
-
SHIBATA Yusuke
Showa Pharmaceutical University
-
OKADA Hideko
Showa Pharmaceutical University
-
NODA Shinobu
Showa Pharmaceutical University
-
KONDOH Masuo
Showa Pharmaceutical University
-
Watanabe Y
Showa Pharmaceutical Univ.
-
Shibata Yusuke
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
-
Fujii M
Showa Univ. Tokyo Jpn
-
Watanabe Yoshiteru
Showa Pharmaceutical Univ.
関連論文
- Study on penetration of titanium dioxide (TiO_2) nanoparticles into intact and damaged skin in vitro
- Effects of Application Method on Skin Penetration of Carboxyfluorescein Incorporated in Liposomes
- Involvement of Oxidative Stress in the Synthesis of Metallothionein Induced by Mitochondrial Inhibitors(Pharmacology)
- Sulfating-Activity and Stability of cDNA-Expressed Allozymes of Human Phenol Sulfotransferase, ST1A31 (^Arg) and ST1A32 (^His), Both of Which Exist in Japanese as Well as Caucasians^1
- Morphological regulation and aggregate formation of rabbit chondrocytes on dendrimer-immobilized surfaces with D-glucose display(CELL AND TISSUE ENGINEERING)
- Effect of Particle Size of Drug on Conversion of Crystals to an Amorphous State in a Solid Dispersion with Crospovidone
- Glucose Transporter Mediation Responsible for Morphological Changes of Human Epithelial Cells on Glucose-Displayed Surfaces(CELL AND TISSUE ENGINEERING)
- Synergistic Effect of D-Glucose and Epidermal Growth Factor Display on Dynamic Behaviors of Human Epithelial Cells(CELL AND TISSUE ENGINEERING)
- Response of Human Epithelial Cells to Culture Surfaces with Varied Roughnesses Prepared by Immobilizing Dendrimers with/without D-Glucose Display(CELL AND TISSUE ENGINEERING)
- Availability of Bone Marrow Stromal Cells in Three-Dimensional Coculture with Hepatocytes and Transplantation into Liver-Damaged Mice(MEDICAL BIOTECHNOLOGY, Advances in Biomedical Science and Engineering)
- Maintenance of Hepatocyte Functions by Coculture with Bone Marrow Stromal Cells (MEDICAL BIOTECHNOLOGY)
- Dendrimer-Immobilized Culture Surface as a Tool to Evaluate Formation of Cellular Cytoskeleton of Anchorage-Dependent Cells (BIOCHEMICAL ENGINEERING)
- タイトジャンクション構成蛋白質Claudinを利用した新規薬物送達方法の構築
- Hepatoprotective Effect of Vitamin B_ on Dimethylnitrosamine-Induced Liver Injury(Pharmacology)
- Protection against D-Galactosamine-Induced Acute Liver Injury by Oral Administration of Extracts from Lentinus edodes Mycelia(Pharmacology)
- Suppression of Cell Death in Primary Rat Hepatocytes by α_1-Acid Glycoprotein(Cell and Tissue Engineering)
- Novel Function of Rare Catechin, Epigallocatechin-3-(3"-O-methyl)gallate, against Cold Injury in Primary Rat Hepatocytes(MISCELLANEOUS)
- Transplantation of Hepatocytes Cultured on Hydroxyapatite into Nagase Analbuminemia Rats (MEDICAL BIOTECHNOLOGY)
- Enhancing Effect of Zinc on Hepatoprotectivity of Epigallocatechin Gallate in Isolated Rat Hepatocytes
- Antioxidative Activity of (-)-Epigallocatechin-3-(3"-O-methyl) gallate Isolated from Fresh Tea Leaf and Preliminary Results on Its Biological Activity
- Effectiveness of Polyamidoamine Dendrimers Modified with Tripeptide Growth Factor, Glycyl-L-Histidyl-L-Lysine, for Enhancement of Function of Hepatoma Cells
- Immobilization of Tripeptide Growth Factor Glycyl-L-histidyl-L-lysine on Poly(vinylalcohol)-quarternized Stilbazole (PVA-SbQ) and Its Use as a Ligand for Hepatocyte Attachment
- Cytostatic effect of phenobarbital on a human hepatoma cell line
- Note of assay of hepatic P-450 activity for evaluation of the function of bioartificial liver support system
- Oxidation of 2-Methoxyphenol by Synthetic Copper-ferrite
- Effectiveness of Fructose-Modified Chitosan as a Scaffold for Hepatocyte Attachment
- Effect of zinc on hepatoprotectivity of α1-acid glycoprotein
- Hepatoprotective Effect of Extracts from Lentinus edodes Mycelia on Dimethylnitrosamine-Induced Liver Injury(Pharmacology)
- Liver Protection by Bis (Maltolato) Zinc(II) Complex
- Correlation between the Physicochemical Property of Some Nonsteroidal Anti-inflammatory Drugs and Changes in Adenosine Triphosphate, Glutathione and Hemoglobin in Rat Erythrocytes(Biopharmacy)
- Evaluation of Pharmacokinetic parameters of Cibenzoline after Administration of a Single Oral Dose in Healthy Volunteers
- Evaluation of Pharmacokinetic Parameters of Cibenzoline after Administration of a Single Oral Dose in Healthy Volunteers
- Determination of concentrations of flecainide in human serum by high-performance liquid chromatography on a fluorocarbon-bonded silica gel column
- Protective Effect of Montmorillonite on Plasmid DNA in Oral Gene Delivery into Small Intestine(Miscellaneous)
- Polyethyleneimine/Chitosan Hexamer-Mediated Gene Transfection into Intestinal Epithelial Cell Cultured in Serum-Containing Medium(MEDICAL BIOTECHNOLOGY)
- 4'-Hydroxylation of Flurbiprofen by Rat Liver Microsomes in Fasting and Feeding Conditions(Biopharmacy)
- Effects of Aspirin and/or Salicylate on Hydrolysis and Glucuronidation of Indomethacin in Rat Erythrocytes and Hepatocytes
- Glucuronidation of Propofol and Its Analogs by Human and Rat Liver Microsomes
- Testicular Toxicity of Mono-n-Butyl Phthalate and Related Phthalates on Bound Iron in Rat Red Blood Cells
- Possible Origin of Rat Testicular Atrophy Induced by Di-n-Butyl Phthalate : Changes in the Activities of Some Enzymes during Rat Testis Perfusion under a Hypoxic Condition and with Mono-n-Butyl Phthalate
- A Computer Program for Pharmacokinetics Based on Maximum Likelihood Estimation Using the Gamma Distribution with a Probability Density Function : Comparison with the Normal Distribution
- Mechanism of Enhancement Effect of Dendrimer on Transdermal Drug Permeation through Polyhydroxyalkanoate Matrix(MISCELLANEOUS)
- Novel Transdermal Drug Delivery System with Polyhydroxyalkanoate and Starburst Polyamidoamine Dendrimer
- Terahertz Absorption Spectra of Original and Generic Ceftazidime
- Review of an alternative to animal testing for safety evaluation of cosmetic ingredients using Quasi-drug : Skin permeation and absorption test task force
- Pharmacokinetics of Acetaminophen from Rapidly Disintegrating Compressed Tablet Prepared Using Microcrystalline Cellulose(PH-M-06)and Spherical Sugar Granules
- Preparation of Rapidly Disintegrating Tablet Using New Types of Microcrystalline Cellulose(PH-M Series)and Low Substituted-Hydroxypropylcellulose or Spherical Sugar Granules by Direct Compression Method
- Preparation of Griseofulvin for Topical Application Using N-Methyl-2-pyrrolidone
- Growth Inhibition of Human Leukemia HL-60 Cells by an Antisense Phosphodiester Oligonucleotide Encapsulated into Fusogenic Liposomes
- Application of Glutaraldehyde-Crosslinked Chitosan as a Scaffold for Hepatocyte Attachment
- In Vitro Maintenance of Liver Function in Hierarchical Co-Culture of Hepatocytes and Non-Parenchymal Liver Cells
- Effect of Polyaniline-coated Surface on the Formation of Multicellular Spheroids of Hepatocytes
- Study on the Discrepancy in Responses Given by Patients to Questions Regarding Subjective Symptoms
- Study on Factors that Contribute to Poor Patient Compliance with Medication in Japan
- New ent-Kaurene-Type Diterpenoids Possessing Cytotoxicity from the New Zealand Liverwort Jungermannia Species
- A Novel Strategy for a Drug Delivery System Using a Claudin Modulator
- Efficient Gene Transfer into Differentiated Human Trophoblast Cells with Adenovirus Vector Containing RGD Motif in the Fiber Protein(Biopharmacy)
- Evaluation of the Compaction Properties of a Solid Dispersion of Indomethacin with Crospovidone by Tableting Process Analyzer
- Efficient Gene Transfer into Human Trophoblast Cells with Adenovirus Vector Containing Chimeric Type 5 and 35 Fiber Protein(Biopharmacy)
- A Novel Method for Predicting Disintegration Time in the Mouth of Rapidly Disintegrating Tablet by Compaction Analysis Using TabAll(Communication to the Editor)
- Cytotoxic and Apoptosis-Inducing ent-Kaurane-Type Diterpenoids from the Japanese Liverwort Jungermannia truncata NEES
- Preparation and Evaluation of Tablets Rapidly Disintegrating in Salive Containing Bitter-Taste-Masked Granules by the Compression Method
- A High-Performance Liquid Chromatographic Determination of Cibenzoline Using Solid-Phase Extraction
- Effect of Tranilast Oily Gel on Carrageenin-Induced Granulation in Rats
- Effect of UV-Absorbing Agents on Photodegradation of Tranilast in Oily Gels
- In Vitro Release of Tranilast from Oily Gels and Penetration of the Drug into Yucatan Micropig Skin
- Evaluation of Yucatan Micropig Skin for Use as an in Vitro Model for Skin Permeation Study
- Screening of Bacteriophages Producing Endo-N-Acetylneuraminidase
- Population Pharmacokinetic Parameters of Valproic Acid ; Conventional and Slow Release Formulation
- A New Compression Tableting Method Using a Punch Coated with Amorphous Alloys
- Molecular Cloning and Characterization of a Novel Bacteriophage-Associated Sialidase
- Activation of Caspase-3 in HL-60 Cells Treated with Pyrithione and Zinc(Toxicology)
- Classical Conditioning of Metallothionein Synthesis in Mice
- Activation of a 36-kDa Myelin Basic Protein Kinase during Cadmium-Induced Apoptosis in Human Leukemia HL-60 Cells
- Cytochrome C Release from Mitochondria Induced by Cadmium
- Cadmium Acetate Mediated Conversion of Selenothioic Acid S-Alkyl Esters to Selenophenes and Ketene Selenothioacetals
- Studies of Drug Delivery Systems for a Therapeutic Agent Used in Osteoporosis. I. Pharmacodynamics (Hypocalcemic Effect) of Elcatonin in Rabbits Following Rectal Administration of Hollow-Type Suppositories Containing Elcatonin
- Pharmacodynamic Activity (Leukopoietic Effect) of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) after Rectal Administration in Rabbits with Leukopenia Induced by Cyclophosphamide
- Note in Statistical Treatment of Medical and Pharmaceutical Data(METHODS, Advances in Biomedical Science and Engineering)
- Application of Partial Least Square on Quantitative Analysis of L-, D-, and DL-Tartaric Acid by Terahertz Absorption Spectra
- Development of a Computer Program, MDGP, for Population Pharmacokinetic Analysis Written Using ANSI C Language on Wide Platforms
- Pharmacokinetics of Propofol Infusions in Japanese Patients
- Magnetic Phase Diagram of Dy Determined by AC Calorimetry
- Possible Origin of Testicular Damage by Phthalic Acid Esters (Proceedings of the 22nd Symposium on Toxicology and Environmental Health)
- Pharmacodynamics and Pharmacokinetics of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) after Administration of a Rectal Dosage Vehicle
- A New Ultraviolet Protective Agent of the Intercalation Compound of Aminobenzoic Acid Esters (UV Absorber) and Synthetic Mica (Inorganic Layered Compound)
- Hepatoprotective Effect of Syringic Acid and Vanillic Acid on CCl4-Induced Liver Injury
- Two Step Conversion of Selenothioacetic Acid S-Butyl Ester to 1, 3-Oxaselenolanes via Regio- and Stereoselective Ring Opening of Oxiranes
- Regulation of Inhibin β Chains and Follistatin mRNA Levels During Rat Hepatocyte Growth Induced by the Peroxisome Proliferator Di-n-butyl Phthalate
- Possible Origin of Testicular Atrophy Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
- Pharmacokinetics and Pharmacodynamics of Human Chorionic Gonadotropin (hCG) after Rectal Administration of Hollow-Type Suppositories Containing hCG
- Effect of Chemical Modification of Tyrosine Residues on Activities of Bacterial Lipase
- Improvement of Heat Stability of Yeast Lipase by Chemical Modification with a Heterobifunctional Photogenerated Reagent
- Application of Terahertz Absorption Spectroscopy to Evaluation of Aging Variation of Medicine
- Studies of Drug Delivery Systems for a Therapeutic Agent Used in Osteoporosis. II. Enhanced Absorption of Elcatonin from Nasal Mucosa in Rabbits
- Hepatoprotective Effect of Syringic Acid and Vanillic Acid on Concanavalin A-Induced Liver Injury
- SOYA LECITHIN AND RELATED MATERIALS AS PHARMACEUTICAL INGREDIENTS
- Influence of pH and Phospholipid Species on Release of Acetaminophen from Tablets Containing Phospholipids
- Effects of Non-covalent Interaction of Dimethyl Suberimidate on Lipase Stability(Biological Chemistry)
- Influence of Admixture with Urea Ointment and White Petrolatum on the Penetration of Corticosteroids into Yucatan Micropig Skin