Pharmacokinetics of Acetaminophen from Rapidly Disintegrating Compressed Tablet Prepared Using Microcrystalline Cellulose(PH-M-06)and Spherical Sugar Granules

スポンサーリンク

概要

• 論文の詳細を見る

• The aim of the present study was to evaluate the bioavailability of a drug from rapidly disintegrating tablets prepared using fine spnerical crystalline cellulose(PH-M-06^R)and spherical sugar granules(Nonpareil^R, NP). Rapidly disintegrating tablets containing acetaminophen as the model drug in combination with a mixture of NP-108(purified D-mannitol)and PH-M-06 were prepared. Plasma concentration profiles and pharmacokinetic parameters of acetaminophen in rabbits were investigated after oral administration of the prepared tablets. No significant difference in C_<max> and AUC_<0-∞> of acetaminophen between rapidly disintegrating tablets and conventional tablets was observed after direct administration of these tablets into the stomach of rabbits. However, t_<max>(15min)of acetaminophen from rapidly disintegrating tablets was significantly(p<0.05)shorter than that from conventional tablets(130min). The same t_<max> was observed for rapidly disintegrating tablets and solution. When suitable excipients such as fine spherical microcrystalline cellulose(PH-M series)and spherical sugar granules(NP series)were used, rapidly disintegrating tablets could be prepared by the conventional direct compression method. According to the results of moment analysis, the mean residence time(MRT) obtained between both rapidly disintegrating and conventional tablets indicates that the mean absorption time(MAT) from these tablets is approximately 60 and 90 min, respectively. This difference in MAT between the two tablets may be caused by the difference in the sum of the mean dissolution time(MDT) and the mean disintegration time(MDIT) of these tablets. Rapidly disintegrating tablets allow rapid absorption of the drug compared with conventional tablets.

• 公益社団法人日本薬学会の論文
• 2001-02-01

著者

• ISHIKAWA Tatsuya

  Department of Surgical Neurology, Research Institute for Brain and Blood Vessels-Akita

• KOIZUMI Naoya

  Department of Radiology, Niigata University School of Medicine

• Fujii Makiko

  Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University

• Watanabe Yoshiteru

  Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University

• Fujii Makiko

  Showa Pharmaceutical Univ.

• Fujii Makiko

  Department Of Chemistry Faculty Of Engineering Gifu University

• ENDO Hisashi

  Department of Medical Oncology, Comprehensive Cancer Center, Saitama Medical University

• Endo H

  Department Of Pharmacy Yokohama City University Hospital

• Endo Hisashi

  Department Of Medical Oncology Comprehensive Cancer Center Saitama Medical University

• Matsumoto Mitsuo

  Department of Pharmaceutics, Showa Pharmaceutical University

• Fujii M

  Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University

• MUKAI Baku

  Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University

• UTOGUCHI Naoki

  Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University

• SHIROTAKE Shoichi

  Department of Pharmacy, Yokohama City University Hospital

• Ishikawa Tsutomu

  Dep. Of Medicinal Organic Chemistry Graduate School Of Pharmaceutical Sciences Chiba Univ.

• Ishikawa Tsutomu

  Graduate School Of Pharmaceutical Sciences Chiba University

• Fukuoka Masamichi

  Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University

• Fukuoka Masamichi

  Division Of Medical Chemistry National Institute Of Hygienic Sciences

• Watanabe Yoshiteru

  Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University

• Ishikawa T

  Graduate School Of Pharmaceutical Sciences Chiba University

• Mukai Baku

  Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University

• Shirotake Shoichi

  Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University

• Koizumi Naoya

  Showa Pharmaceutical Univ.

• Fujii M

  Showa Univ. Tokyo Jpn

• Matsumoto Mitsuo

  Department Of Pharmaceutics Showa Pharmaceutical University

• Murata Masahiro

  Department Of Pharmacy Services Tama Nagayama Hospital Nippon Medical School

• Koizumi N

  Research Department Teikoku Hormone Mfg. Co. Ltd.

• Ishikawa Tsutomu

  Graduate School Of Pharmaceutical Sciences Chiba Univ.

• Watanabe Yoshiteru

  Showa Pharmaceutical Univ.

• Koizumi Naoya

  Department Of Bioengineering Tokyo Institute Of Technology

• Ishikawa Tatsuya

  Department Of Neonatology And Pediatrics Nagoya City University Graduate School Of Medical Sciences

• Utoguchi Naoki

  Department Of Biopharmaceutics School Of Pharmaceutical Sciences Teikyo University

• Endo H

  Department Of Drug Metabolism Research Center Taisho Pharmacetutical Co. Ltd.

• Matsumoto Mitsuo

  Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University

• Ishikawa Tatsuya

  Department Of Civil Engineering Nagoya University

• Ishikawa Tatsuya

  Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo

• Shiraishi Shuji

  Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University

• Matsumoto Mitsuo

  Department Of Ophthalmology Hirosaki University School Of Medicine

• ENDO HISASHI

  Department of Internal Medicine, National Shikoku Cancer Center

• Ishikawa Toshihisa

  Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology

• Ishikawa Toshihisa

  Graduate School of Pharmaceutical Sciences, Chiba University

• Matsumoto Mitsuo

  Department of Hydrocarbon Chemistry, Faculty of Engineering, Kyoto University

関連論文

• Impact of Early Surgical Evacuation of Sylvian Hematoma on Clinical Course and Outcome After Subarachnoid Hemorrhage
• Effects of Application Method on Skin Penetration of Carboxyfluorescein Incorporated in Liposomes
• Sulfating-Activity and Stability of cDNA-Expressed Allozymes of Human Phenol Sulfotransferase, ST1A31 (^Arg) and ST1A32 (^His), Both of Which Exist in Japanese as Well as Caucasians^1
• Subsequent Epilepsy in Very-Low-Birthweight Infants : A Long-Term Follow-Up Study from Birth
• Microcystic variant of localized malignant mesothelioma accompanying an adenomatoid tumor-like lesion
• Effect of Particle Size of Drug on Conversion of Crystals to an Amorphous State in a Solid Dispersion with Crospovidone
• Association of ATP-Binding Cassette, Sub-family C, Number 2 (ABCC2) Genotype with Pharmacokinetics of Irinotecan in Japanese Patients with Metastatic Colorectal Cancer Treated with Irinotecan Plus Infusional 5-Fluorouracil/Leucovorin (FOLFIRI)(Miscellaneo
• CYP2A6 and the plasma level of 5-chloro-2,4-dihydroxypyridine are determinants of the pharmacokinetic variability of tegafur and 5-fluorouracil, respectively, in Japanese patients with cancer given S-1
• Hematomyelia Caused by Ruptured Intramedullary Spinal Artery Aneurysm Associated With Extramedullary Spinal Arteriovenous Fistula : Case Report
• A novel coating biomaterial for intracranial aneurysms : Effects and safety in extra- and intracranial carotid artery
• Prevalence and features of migraine in Japanese junior high school students aged 12-15yr
• Cardiac Vagal Activation by Adrenocorticotropic Hormone Treatment in Infants with West Syndrome
• Magnetic Resonance Angiography for Detection of Occlusive Neck and Proximal Vascular Diseases
• Clinical Study of Cerebrospinal Fluid Dynamics Using ^In-DTPA SPECT in Patients With Subarachnoid Hemorrhage
• Reference Table Predicting the Outcome of Subarachnoid Hemorrhage in the Elderly, Stratified by Age
• Operative Anatomy and Classification of the Sylvian Veins for the Distal Transsylvian Approach
• STUDY ON THE TRANSIENT STRESS FIELD FROM WAVE PROPAGATION TO OSCILLATION STATE IN RC COLUMNS
• STRESS WAVE PROPAGATION IN A COLUMN WITH REINFORCEMENT DISCONTINUITY
• Correlation between the Physicochemical Property of Some Nonsteroidal Anti-inflammatory Drugs and Changes in Adenosine Triphosphate, Glutathione and Hemoglobin in Rat Erythrocytes(Biopharmacy)
• Evaluation of Pharmacokinetic parameters of Cibenzoline after Administration of a Single Oral Dose in Healthy Volunteers
• Evaluation of Pharmacokinetic Parameters of Cibenzoline after Administration of a Single Oral Dose in Healthy Volunteers
• Determination of concentrations of flecainide in human serum by high-performance liquid chromatography on a fluorocarbon-bonded silica gel column
• Brain Stem Arteriovenous Malformation With Large Venous Varix
• Childhood Ischemic Stroke Caused by Fibromuscular Dysplasia of the Intracranial Artery : Case Report
• Granular cell tumor occurring in the sigmoid colon treated by endoscopic mucosal resection using a transparent cap (EMR-C)
• Evaluation of endoscopic injection sclerotherapy with and without simultaneous ligation for the treatment of esophageal varices
• Circulating vascular endothelial growth factor(VEGF) is a possible tumor marker for metastasis in human hepatocellular carcinoma
• A Computer Program for Pharmacokinetics Based on Maximum Likelihood Estimation Using the Gamma Distribution with a Probability Density Function : Comparison with the Normal Distribution
• Pharmacokinetics of Acetaminophen from Rapidly Disintegrating Compressed Tablet Prepared Using Microcrystalline Cellulose(PH-M-06)and Spherical Sugar Granules
• Preparation of Rapidly Disintegrating Tablet Using New Types of Microcrystalline Cellulose(PH-M Series)and Low Substituted-Hydroxypropylcellulose or Spherical Sugar Granules by Direct Compression Method
• Preparation of Griseofulvin for Topical Application Using N-Methyl-2-pyrrolidone
• Pharmacogenetic impact of polymorphisms in the coding region of the UGT1A1 gene on SN-38 glucuronidation in Japanese patients with cancer
• Novel Single Nucleotide Polymorphism of UGT1A9 Gene in Japanese
• Novel Single Nucleotide Polymorphism of UGT1A7 Gene in Japanese
• Changes and equalization in hearing level induced by dental treatment and instruction in bilaterally equalized chewing: a clinical report
• Study on the Discrepancy in Responses Given by Patients to Questions Regarding Subjective Symptoms
• Study on Factors that Contribute to Poor Patient Compliance with Medication in Japan
• New ent-Kaurene-Type Diterpenoids Possessing Cytotoxicity from the New Zealand Liverwort Jungermannia Species
• A Novel Strategy for a Drug Delivery System Using a Claudin Modulator
• Efficient Gene Transfer into Differentiated Human Trophoblast Cells with Adenovirus Vector Containing RGD Motif in the Fiber Protein(Biopharmacy)
• Evaluation of the Compaction Properties of a Solid Dispersion of Indomethacin with Crospovidone by Tableting Process Analyzer
• Efficient Gene Transfer into Human Trophoblast Cells with Adenovirus Vector Containing Chimeric Type 5 and 35 Fiber Protein(Biopharmacy)
• A Novel Method for Predicting Disintegration Time in the Mouth of Rapidly Disintegrating Tablet by Compaction Analysis Using TabAll(Communication to the Editor)
• Universal External Carotid Artery to Proximal Middle Cerebral Artery Bypass With Interposed Radial Artery Graft Prior to Approaching Ruptured Blood Blister-Like Aneurysm of the Internal Carotid Artery : Technical Note
• Simultaneous Superficial Temporal Artery to Middle Cerebral or Anterior Cerebral Artery Bypass With Pan-synangiosis for Moyamoya Disease Covering Both Anterior and Middle Cerebral Artery Territories : Technical Note
• Prevalence of Asymptomatic Microbleeds in Patients With Moyamoya Disease
• Preparation and Evaluation of Tablets Rapidly Disintegrating in Salive Containing Bitter-Taste-Masked Granules by the Compression Method
• Heat shock protein of Mycoplasma salivarium and Mycoplasma orale strains isolated from HIV-seropositive patients
• A High-Performance Liquid Chromatographic Determination of Cibenzoline Using Solid-Phase Extraction
• Effect of Tranilast Oily Gel on Carrageenin-Induced Granulation in Rats
• Effect of UV-Absorbing Agents on Photodegradation of Tranilast in Oily Gels
• In Vitro Release of Tranilast from Oily Gels and Penetration of the Drug into Yucatan Micropig Skin
• Normal Tension Glaucoma and Primary Open Angle Glaucoma Associated with Increased Platelet Aggregation
• Distal Posterior Inferior Cerebellar Aneurysms : Report of 12 Cases
• STA-MCA Bypass Surgery for Internal Carotid Artery Occlusion : Comparative Follow-up Study
• Epilepsies after Pocket Monster Seizures
• Population Pharmacokinetic Parameters of Valproic Acid ; Conventional and Slow Release Formulation
• A New Compression Tableting Method Using a Punch Coated with Amorphous Alloys
• ACUTE AND SUBCHRONIC EFFECTS OF BOMETOLOL ON BLOOD PRESSURE IN HYPERTENSIVE RATS
• Activation of Caspase-3 in HL-60 Cells Treated with Pyrithione and Zinc(Toxicology)
• Classical Conditioning of Metallothionein Synthesis in Mice
• Activation of a 36-kDa Myelin Basic Protein Kinase during Cadmium-Induced Apoptosis in Human Leukemia HL-60 Cells
• Brain Metastasis in Malignant Pleural Mesothelioma Presenting as Intratumoral Hemorrhage : Case Report
• Cadmium Acetate Mediated Conversion of Selenothioic Acid S-Alkyl Esters to Selenophenes and Ketene Selenothioacetals
• Studies of Drug Delivery Systems for a Therapeutic Agent Used in Osteoporosis. I. Pharmacodynamics (Hypocalcemic Effect) of Elcatonin in Rabbits Following Rectal Administration of Hollow-Type Suppositories Containing Elcatonin
• Pharmacodynamic Activity (Leukopoietic Effect) of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) after Rectal Administration in Rabbits with Leukopenia Induced by Cyclophosphamide
• Development of a Computer Program, MDGP, for Population Pharmacokinetic Analysis Written Using ANSI C Language on Wide Platforms
• Acute Drug Poisoning at Critical Care Departments in Japan
• Pharmacokinetics of Propofol Infusions in Japanese Patients
• Parameter Estimatability of Robust Estimation in Pharmacokinetic Analysis
• Magnetic Phase Diagram of Dy Determined by AC Calorimetry
• Concept of Ideal Closure Line for Clipping of Middle Cerebral Artery Aneurysms : Technical Note
• Preparation and Evaluation of Heat-sensitive Melting Gel : Acetaminophen Gel
• The Effect of Dried Aluminum Hydroxide Gel on the Blood Concentration of Cyclosporine-A
• MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA OCCURRING IN THE TRANSVERSE COLON
• Classification of Air Density Areas in CT - Pathologic Correlation of Pulmonary Adenocarcinoma
• Cloudy Nodule on HRCT : A New Clinico - Radiologic Entity of Pulmonary Adenocarcinoma
• Pulmonary myxoid leiomyosarcoma
• Release Rates of Kampo Extract from Witepsol Suppositories and Its Rectal Absorption in Rabbits
• Optimum Design of Vehicle Frontal Structure and Occupant Restraint System for Crashworthiness : A Multilevel Approach Using SDSS
• Diffuse central nervous system lupus involving white matter, basal ganglia, thalami and brainstem
• Serial MRI findings of benign poliomyelitis
• Consolidation and Drug Release Characteristics of Macrogol-Matrix Tablets Containing Nifedipine and Increased Bioavailability of Nifedipine from These Tablets in Rabbits
• Additional Carbohydrate-Binding Modules Enhance the Insoluble Substrate-Hydrolytic Activity of β-1,3-Glucanase from Alkaliphilic Nocardiopsis sp. F96
• Pharmacodynamics and Pharmacokinetics of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) after Administration of a Rectal Dosage Vehicle
• A New Ultraviolet Protective Agent of the Intercalation Compound of Aminobenzoic Acid Esters (UV Absorber) and Synthetic Mica (Inorganic Layered Compound)
• Duration of Absorption-Enhancing Effect of Sodium Octanoate, Sodium Hexanoate or Glyceryl-1-monooctanoate on Rectal Absorption of Gentamicin in Rabbits
• Improvement of Hospital Preparation for Patient Oriented Service : Tablet of Bitter Tasting-Stomachic Powder
• Additional Carbohydrate-Binding Modules Enhance the Insoluble Substrate-Hydrolytic Activity of β-1,3-Glucanase from Alkaliphilic Nocardiopsis sp. F96
• Bilateral occipital cortical dysplasia and white matter T2 hyperintensity with mild non-specific myopathy : Two sibling cases
• Two Step Conversion of Selenothioacetic Acid S-Butyl Ester to 1, 3-Oxaselenolanes via Regio- and Stereoselective Ring Opening of Oxiranes
• PHARMACEUTICAL EVALUATION OF HOLLOW TYPE SUPPOSITORIES. V. PREPARATION OF VALPROIC ACID SUPPOSITORY AND RECTAL ABSORPTION OF VALPROIC ACID IN RABBITS
• PHARMACEUTICAL EVALUATION OF HOLLOW TYPE SUPPOSITORIES. IV. IMPROVEMENT OF BIOAVAILABILITY OF PROPRANOLOL IN RABBITS AFTER RECTAL ADMINISTRATION
• PHARMACEUTICAL EVALUATION OF HOLLOW TYPE SUPPOSITORY
• Pharmacokinetics and Pharmacodynamics of Human Chorionic Gonadotropin (hCG) after Rectal Administration of Hollow-Type Suppositories Containing hCG
• Gastric Cancer Concomitant with Inflammatory Fibroid Polyp Treated with Endoscopic Mucosal Resection Using an Insulation-tip Diathermic Knife
• Studies of Drug Delivery Systems for a Therapeutic Agent Used in Osteoporosis. II. Enhanced Absorption of Elcatonin from Nasal Mucosa in Rabbits
• Influence of Admixture with Urea Ointment and White Petrolatum on the Penetration of Corticosteroids into Yucatan Micropig Skin
• Percolation Analysis in Electrical Conductivity of Madin-Darby Canine Kidney and Caco-2 Cells by Permeation-Enhancing Agents

もっと見る 閉じる

スポンサーリンク