Activation of a 36-kDa Myelin Basic Protein Kinase during Cadmium-Induced Apoptosis in Human Leukemia HL-60 Cells
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概要
- 論文の詳細を見る
Cadmium (Cd) is a well-known modulator of intracellular signal transduction including mitogen-activated protein kinases and protein kinase C. In this study, we investigated activation of a kinase using myelin basic protein (MBP) as a substrate during Cd-induced apoptosis in human leukemia HL-60 cells. To detect a kinase during Cd-induced apoptosis in HL-60 cells, we performed an in-gel kinase assay using MBP as a substrate and found that Cd induced the activation of a kinase with an apparent molecular mass of 36 kDa. The time-course of appearance of DNA ladders induced by Cd was consistent with that of activation of this kinase. The kinetics of activation of p36 MBP kinase was different from that of p38 mitogen-activated protein kinase (p38MAPK). Activation of p36 MBP kinase was also observed with kinetics distinct from that of activation of p38MAPK during mercuric chloride-induced apoptosis. This is the first report on activation of p36 MBP kinase during Cd- or Hg-induced apoptosis.
- 公益社団法人日本薬学会の論文
- 2004-06-01
著者
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近藤 昌夫
Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Watanabe Yoshiteru
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
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Sato Masao
徳島文理大学 薬学部
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Sato Masao
Department Of Legal Medicine Fukushima Medical University School Of Medicine
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KONDOH Masuo
Department of Biopharmaceutics and Pharmaceutics, Showa Pharmaceutical University
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Watanabe Yoshiteru
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Kondoh Masuo
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Sato Masao
Department Of Applied Biological Chemistry Graduate School Of Bioresource And Bioenvironmental Scien
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