Production of Interleukin-6 and Its Implication in Rats after Subcutaneous Injection of Carbon Tetrachloride

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概要

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• Previously, we have reported that interleukin-6 (IL-6) administration reduces hepatic injury caused by carbon tetrachloride (CCl_4) and induces the production of antioxidant proteins, manganese superoxide dismutase and metallothionein. In the present study, we examined whether IL-6 was induced endogenously by CCl_4 administration in rats, and examined the relationship between the levels of IL-6 production and hepatic injury. Plasma samples were periodically collected after s.c. administration of 5 ml/kg of CCl_4 (50%, v/v, in corn oil). IL-6 was significantly produced at 1.5 hr after administration, peaked at 8 hr and gradually decreased thereafter. The activities of hepatic marker enzymes, alanine aminotransferase (ALT) and sorbitol dehydrogenase (SDH) in plasma, gradually increased and peaked at 48 hr. As the ratio of the amount of corn oil to that of carbon tetrachloride was increased in the range of 1 : 0 to 1 : 8 (v/v), IL-6 induction was decreased, while ALT and SDH activities were augmented. When rats were treated with a pharmacological dose of dexamethasone (1 mg/kg), IL-6 production was decreased, but ALT and SDH activities were augmented. IL-6 expression immediately after CCl_4 administration is suggested to play some significant role in reducing hepatic injury. These findings should be thoroughly considered when the hepatic injury model is developed based on the s.c. administration of CCl_4.

• 公益社団法人日本薬学会の論文
• 2002-04-01

著者

• Sato Masao

  Department Of Legal Medicine Fukushima Medical University School Of Medicine

• CHIKUMA Toshiyuki

  Department of Hygienic Chemistry, Showa Pharmaceutical University

• HOJO Hiroshi

  Department of Pathology, Fukushima Medical University School of Medicine

• Chikuma Toshiyuki

  Department Of Hygienic Chemistry Showa Pharmaceutical University

• Yamaguchi Mitsune

  Department of Hygienic Chemistry, Showa Pharmaceutical University

• Kasakura Tetsuya

  Department of Hygienic Chemistry, Showa Pharmaceutical University

• Zuinen Ryoji

  Department of Hygienic Chemistry, Showa Pharmaceutical University

• Aoki Miho

  Department of Hygienic Chemistry, Showa Pharmaceutical University

• Aoki Miho

  Department Of Hygienic Chemistry Showa Pharmaceutical University

• Zuinen Ryoji

  Department Of Hygienic Chemistry Showa Pharmaceutical University

• Hojo Hiroshi

  Department Of Hygienic Chemistry Showa Pharmaceutical University

• Kasakura Tetsuya

  Department Of Hygienic Chemistry Showa Pharmaceutical University

• Yamaguchi M

  Keio Univ. Tokyo Jpn

• Hojo Hiroshi

  Lab. Of Hygienic Chemistry Showa Pharmaceutical Univ.

• Hojo Hiroshi

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Tohoku University

• Yamaguchi Masatoshi

  Department Of Obstetrics And Gynecology Miyazaki Medical College University Of Miyazaki

• Sato Masao

  Department Of Applied Biological Chemistry Graduate School Of Bioresource And Bioenvironmental Scien

• Hojo Hiroshi

  Department Of First Pathology Fukushima Medical University Fukushima

• Hojo Hiroshi

  Department Of Diagnostic Pathology Fukushima Medical University

• Chikuma Toshiyuki

  Department of Analytical Chemistry of Medicines, Showa Pharmaceutical University

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