Insufficient Metallothionein Synthesis in the Lung and Kidney in Human Acute Inorganic Mercury Poisoning
スポンサーリンク
概要
- 論文の詳細を見る
It has been assumed that "smelter disease" is caused by sulfuric dioxide. A typical episode resulting in "smelter disease" occurred in Fukushima, Japan. Twenty-seven workers became ill and eventually three of them died. The concentration of mercury (Hg) was found to be higher in all tissues and blood of the three victims than in those of normal Japanese, although the concentrations of zinc, cadmium, copper and lead in all tissues examined were within the normal range. The clinical course after the incident and autopsy findings clarified the cause of death to be acute Hg fume poisoning. To determine the histological localization of Hg and metallothionein (MT), Hg staining by the photo-emulsion method and immunostaining using anti-MT antibody were carried out. Numerous Hg granules were observed in the epithelia of the proximal tubules of the renal cortex using the photo-emulsion histochemical method. The liver of victims contained a few Hg granules in the hepatic cellular cytoplasm and sinusoid. Immunostaining of the kidney showed a strong positive reaction with anti-MT in the proximal tubules outside the medulla. The presence of Hg-bound MT in the kidneys of the victims was confirmed by gel chromatography. This is the first evidence of Hg-MT in the tissues of humans with acute Hg fume poisoning. Mercury might induce the synthesis of MT in human tissues. In addition, fractionation of the supernatants on gel chromatography revealed that most of the Hg in the kidney and lung of the patient who had the most severe renal and lung damage and who was the first of the three victims to die was distributed in high molecular weight protein fractions (HMW) and a small portion of Hg was bound to MT. These findings suggest that the amount of synthesized MT in tissues was not sufficient for MT to bind to Hg. The amount of Hg absorbed into tissues may be too large for MT to protect tissues, and thereby Hg may be bound to HMW.
- 公益社団法人日本薬学会の論文
- 1999-12-31
著者
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ODAJIMA Hajime
Department of Pathology, Ohta-Nishinouchi Hospital
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SATOH Hiroshi
Environmental Health Science, Tohoku University Graduate School of Medicine and Pharmaceutical Scien
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Mochizuki Mamoru
Department of Medical Bioregulation, Division of Cardiovascular Medicine, Yamaguchi University Schoo
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Odajima Hajime
Department Of Pathology Fukushima Medical University School Of Medicine
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Watanabe Chiho
Environmental Health Sciences Tohoku University Graduate School Of Medicine
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Watanabe Chiho
Environmental Health Sciences Tohoku University Graduate School Of Medicine:tokyo University Graduat
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Sato Masao
Department Of Legal Medicine Fukushima Medical University School Of Medicine
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Sato Masao
Institute Of Biomedical Sciences Fukushima Medical College
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Sato Masao
Laboratory Of Pharmaceutical Proteomics National Institute Of Biomedical Innovation:department Of Bi
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Mochizuki Mamoru
Department Of Pathology Iwaki Kyoritsu Hospital
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Mochizuki Mamoru
Department Of Medical Bioregulation Division Of Cardiovascular Medicine Yamaguchi University School
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Sato M
Department Of Legal Medicine Fukushima Medical University School Of Medicine
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Wakasa Haruki
Tohoku Bunka Gakuen University
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Wakasa Haruki
Departments Of Pathology Fukushima Medical College
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Wakasa Haruki
Department Of Pathology Fukushima Medical College
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Hiraiwa Kouichi
Department Of Biochemistry Fukushima Medical University School Of Medicine
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SATOH Hiroshi
Biochemicals Division, Yamasa Corporation
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GUNJI Hirobumi
Department of Legal Medicine, Fukushima Medical University School of Medicine
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KURISAKI Emiko
Department of Legal Medicine, Fukushima Medical University School of Medicine
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ASANO Sigeyuki
Department of Pathology, Iwaki Kyoritsu General Hospital
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Asano Sigeyuki
Department Of Pathology Iwaki Kyoritsu General Hospital
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Gunji Hirobumi
Department Of Legal Medicine Fukushima Medical University School Of Medicine
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Kurisaki E
Department Of Legal Medicine Fukushima Medical University School Of Medicine
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Kurisaki Emiko
Department Of Legal Medicine Fukushima Medical College
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Satoh H
Biochemicals Division Yamasa Corporation
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Satoh Hiroshi
Environmental Health Science Tohoku University Graduate School Of Medicine
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Satoh Hiroshi
Enviromental Health Sciences Tohoku University School Of Medicine
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