An Association Between Long-Term Exposure to Ambient Air Pollution and Mortality From Lung Cancer and Respiratory Diseases in Japan
スポンサーリンク
概要
- 論文の詳細を見る
Background: Evidence for a link between long-term exposure to air pollution and lung cancer is limited to Western populations. In this prospective cohort study, we examined this association in a Japanese population.Methods: The study comprised 63 520 participants living in 6 areas in 3 Japanese prefectures who were enrolled between 1983 and 1985. Exposure to particulate matter less than 2.5 µm in aerodynamic diameter (PM2.5), sulfur dioxide (SO2), and nitrogen dioxide (NO2) was assessed using data from monitoring stations located in or nearby each area. The Cox proportional hazards model was used to calculate the hazard ratios associated with the average concentrations of these air pollutants.Results: The 10-year average concentrations of PM2.5, SO2, and NO2 before recruitment (1974–1983) were 16.8 to 41.9 µg/m3, 2.4 to 19.0 ppb, and 1.2 to 33.7 ppb, respectively (inter-area range). During an average follow-up of 8.7 years, there were 6687 deaths, including 518 deaths from lung cancer. The hazard ratios for lung cancer mortality associated with a 10-unit increase in PM2.5 (µg/m3), SO2 (ppb), and NO2 (ppb) were 1.24 (95% confidence interval: 1.12–1.37), 1.26 (1.07–1.48), and 1.17 (1.10–1.26), respectively, after adjustment for tobacco smoking and other confounding factors. In addition, a significant increase in risk was observed for male smokers and female never smokers. Respiratory diseases, particularly pneumonia, were also significantly associated with all the air pollutants.Conclusions: Long-term exposure to air pollution is associated with lung cancer and respiratory diseases in Japan.
著者
-
SATOH Hiroshi
Environmental Health Science, Tohoku University Graduate School of Medicine and Pharmaceutical Scien
-
NAKATSUKA Haruo
School of Nursing, Miyagi University
-
TAKEZAKI Toshiro
Department of International Island and Community Medicine, Graduate School of Medical and Dental Sci
-
TOMINAGA Suketami
Aichi Cancer Center
-
SOBUE Tomotaka
Cancer Information and Epidemiology Division, National Cancer Center Research Institute
-
Katanoda Kota
Cancer Information Services and Surveillance Division, Center for Cancer Control and Information Ser
-
Tajima Kazuo
Aichi Cancer Center Research Institute
-
Suzuki Takaichiro
Department of Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Dise
-
Nakayama Tomio
Department of Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Dise
-
Nitta Hiroshi
Environmental Health Sciences Division, National Institute for Environmental Studies
-
Tanabe Kiyoshi
Environmental Chemistry Division, National Institute for Environmental Studies
関連論文
- Association of Mast Cell Chymase Gene Variant with HDL Cholesterol, but not with Blood Pressure in the Ohasama Study
- Blood Pressure Control Assessed by Home, Ambulatory and Conventional Blood Pressure Measurements in the Japanese General Population : the Ohasama Study
- Dietary Sources of Nutrient Consumption in a Rural Japanese Population
- Soy consumption reduces the risk of non-small-cell lung cancers with epidermal growth factor receptor mutations among Japanese
- Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARγ gene and colorectal cancer risk in Japanese
- Association between Smoking Habits and Dopamine Receptor D2 Taql A A2 Allele in Japanese Males : a Confirmatory Study
- A Limited Association of OGG1 Ser326Cys Polymorphism for Adenocarcinoma of the Lung
- Usefulness of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for undiagnosed intra-abdominal lymphadenopathy
- Genotoxicity Studies of Heavy Metals : Lead, Bismuth, Indium, Silver and Antimony
- Oral Toxicity of Indium in Rats : Single and 28-Day Repeated Administration Studies
- Oral Toxicity of Bismuth in Rat : Single and 28-Day Repeated Administration Studies
- A 13-Week Toxicity Study of Bismuth in Rats by Intratracheal Intermittent Administration
- Lifestyle factors associated with atrophic gastritis among Helicobacter pylori-seropositive Japanese-Brazilians in Sao Paulo
- Helicobacter pylori Seropositivity among 963 Japanese Brazilians According to Sex, Age, Generation, and Lifestyle Factors
- Impact of Established Risk Factors for Breast Cancer in Nulligravid Japanese Women
- Aldehyde Dehydrogenase 2 (ALDH2) Genotype Affects Rectal Cancer Susceptibility Due to Alcohol Consumption
- Correlation between foods consumption and colorectal cancer : An ecological analysis in Japan
- Alcohol, Smoking, and Dietary Status and Susceptibility to Malignant Lymphoma in Japan : Results of a Hospital-based Case-control Study at Aichi Cancer Center
- Smoking Habit and Interleukin 1B C-31T Polymorphism
- Possible Risk Reduction in Esophageal Cancer Associated with MPO -463 A allele
- Effect of Life Styles on the Risk of Subsite-Specific Gastric Cancer in Those with and without Family History
- The Estimation of Cancer Incidence in Aichi Prefecture, Japan : Use of 'Degree of Completeness of Registration'
- Lifestyle and Anti-Helicobacter pylon Immunoglobulin G Antibody among Outpatients
- Lung Cancer Incidence Rates by Histologic Type in High- and Low- Risk Areas ; A Population-Based Study in Osaka, Okinawa, and Saku Nagano, Japan
- Polymorphism in the 3'-untranslated region of the thymidylate synthase gene and sensitivity of stomach cancer to fluoropyrimidine-based chemotherapy
- An Association Between Long-Term Exposure to Ambient Air Pollution and Mortality From Lung Cancer and Respiratory Diseases in Japan
- A Case of Achondroplasia Associated with Cervicomedullary-Junction Compression
- Intrahepatic cholangiocarcinoma arising 10 years after the excision of congenital extrahepatic biliary dilation
- Reproducibility of a Short Food Frequency Questionnaire for Japanese General Population
- Longitudinal Changes in Medical Examination Data of Ex-Smokers in Comparison with Smokers and Non-Smokers
- Anthropometric, Lifestyle and Biomarker Assessment of Japanese Non-professional Ultra-marathon Runners
- Association of p53 Codon Arg72Pro and p73 G4C14-to-A4T14 at Exon 2 Genetic Polymorphisms with the Risk of Japanese Breast Cancer
- Hepatitis B and C Viruses Infection, Lifestyle and Genetic Polymorphisms as Risk Factors for Hepatocellular Carcinoma in Haimen, China
- Associations between Physical Strength, Cerebral Function and Mental Health in Independent-Living Elderly Japanese Women
- Foods Contributing to Absolute Intake and Variance in Intake of Selected Vitamins, Minerals and Dietary Fiber in Middle-Aged Japanese
- Foods Contributing to Absolute Intake and Variance in Intake of Fat, Fatty Acids and Cholesterol in Middle-aged Japanese
- Reduced risk of endometrial cancer from alcohol drinking in Japanese
- Association between vitamin D and calcium intake and breast cancer risk according to menopausal status and receptor status in Japan
- Heavy smoking history interacts with chemoradiotherapy for esophageal cancer prognosis : A retrospective study
- Interaction of the Effects of Alcohol Drinking and Polymorphisms in Alcohol-Metabolizing Enzymes on the Risk of Female Breast Cancer in Japan
- Impact of alcohol consumption with polymorphisms in alcohol-metabolizing enzymes on pancreatic cancer risk in Japanese
- One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma : Case-control study
- Dietary patterns and the risk of breast cancer in Japanese women
- Coffee consumption and the risk of endometrial cancer : Evidence from a case-control study of female hormone-related cancers in Japan
- CANCER MORTALITY STATISTICS IN 30 COUNTRIES (1953-1997)
- CANCER MORTALITY IN JAPAN (1950-2000)
- Epidemiology of Breast Cancer in Japan
- Epidemiology and Prevention of Breast Cancer in the 21st Century
- Epidermal growth factor receptor mutation, but not sex and smoking, is independently associated with favorable prognosis of gefitinib-treated patients with lung adenocarcinoma
- LKB1 gene mutations in Japanese lung cancer patients
- Biological and clinical implications of EGFR mutations in lung cancer
- NAD(P)H : quinone oxidoreductase 1 (NQ01) C609T polymorphism and the risk of eight cancers for Japanese
- Effectiveness of Mass Screening for Breast Cancer in Japan
- CANCER MORTALITY IN JAPAN (1950-1995)
- Effects of hemoglobin derivatives on the liver microcirculation system ; evaluation of the s-nitroso-polyethylene glycol modified hemoglobin as an artificial oxygen carrier
- Identification of Cancer Antigens in Breast Cancer by the SEREX Expression Cloning Method
- Permanent Waving Does not Change Mercury Concentration in the Proximal Segment of Hair Close to Scalp
- Ambulatory Blood Pressure Monitoring in Evaluating the Prevalence of Hypertension in Adults in Ohasama, a Rural Japanese Community
- Background Characteristics of Basic Health Examination Participants : the JPHC Study Baseline Survey
- HTLV-1 provirus load in peripheral blood lymphocytes of HTLV-1 carriers is diminished by green tea drinking
- Serratia marcescens lung abscess in a child with autoimmune meutropenia
- Smoking behavior and attitudes toward smoking cessation among members of the Japanese Cancer Association in 2004 and 2006
- Cancer mortality in Thorotrast-exposed patients in Japan : Aichi series
- Low Expression Myeloperoxidase Genotype Negatively Associated with Helicobacter pylori Infection
- CANCER MORTALITY STATISTICS IN 33 COUNTRIES (1953-1992)
- Mortality Risks of Oesophageal Cancer Associated with Hot Tea, Alcohol, Tobacco and Diet in Japan
- Validity and Reproducibility of a Self-administered Food Frequency Questionnaire in the JPHC Study Cohort II : Study Design, Participant Profile and Results Comparison with Cohort I
- Smoking and Drinking Habits among the JPHC Study Participants at Baseline Survey
- Dietary Habits among the JPHC Study Participants at Baseline Survey
- Smoking and Risk of Premature Death among Middle-aged Japanese : Ten-year Follow-up of the Japan Public Health Center-based Prospective Study on Cancer and Cardiovascular Diseases (JPHC Study) Cohort I
- Baseline Survey of JPHC Study-Design and Participation Rate
- Population Attributable Fraction of Mortality Associated with Tobacco Smoking in Japan : A Pooled Analysis of Three Large-scale Cohort Studies
- Reduced Life Expectancy due to Smoking in Large-Scale Cohort Studies in Japan
- Trends in Growth Status among Schoolchildren in Sendai, Japan, 1994-2003 : Leveling-Off of Mean Body Height and Weight
- Interleukin 1 polymorphisms, Lifestyle Factors, and Helicobacter pylori Infection
- Projection of lung cancer mortality in Japan
- Assessment of Intrauterine Methylmercury Exposure Affecting Child Development : Messages from the Newborn
- Estimation of Daily Mercury Intake from Seafood in Japanese Women : Akita Cross-Sectional Study
- Secular Trends in Neuroblastoma Mortality Before and After the Cessation of National Mass Screening in Japan
- Research Activities of Cancer Epidemiology in Japan
- Awareness of and adherence to cancer screening guidelines among health professionals in Japan
- Reproducibility of Diagnosis and Its Influence on the Distribution of Lung Cancer by Histologic Type in Osaka, Japan
- CLINICAL STATISTICS ON REGISTERED BREAST CANCER PATIENTS IN JAPAN
- Interventional Trial for Colorectal Cancer Prevention in Osaka : An Introduction to the Protocol
- Tea Polyphenol Intake and Changes in Serum Pepsinogen Levels
- PREFACE
- Evaluation of usefulness of in-vitro drug sensitivity testing for adjuvant chemotherapy of stomach cancer
- International Cooperative Research
- Residential Radon Exposure and Lung Cancer Risk in Misasa, Japan: a Case-control Study
- Mortality and Cancer Incidence in Misasa, Japan, a Spa Area with Elevated Radon Levels
- The Effect of Prenatal Methylmercury Exposure on the GSH Level and Lipid Peroxidation in the Fetal Brain and Placenta of Mice
- Effects of Mild Chronic Heat Exposure on the Concentrations of Thiobarbituric Acid Reactive Substances, Glutathione, and Selenium, and Glutathione Peroxidase Activity in the Mouse Liver
- Trends of Lung Cancer Incidence by Histologic Type : A Population-based Study in Osaka, Japan
- Insufficient Metallothionein Synthesis in the Lung and Kidney in Human Acute Inorganic Mercury Poisoning
- Smoking and Drinking Habits among the JPHC Study Participants at Baseline Survey
- Effect of Zinc Deficiency on the Behavior of Metallothionein-I, II Knockout Mice
- Use of a Population-Based Cancer Registry to Calculate Twenty-Year Trends in Cancer Incidence and Mortality in Fukui Prefecture
- An Association Between Long-Term Exposure to Ambient Air Pollution and Mortality From Lung Cancer and Respiratory Diseases in Japan
- A Phase III study of combination therapy of the oral fluorinated pyrimidine compound tegafur-uracil (UFT) with low dose cisplatin compared with UFT alone in patients with locally advanced gastric cancer as postoperative adjuvant chemotherapy
- Case-control Study of Bowel Habits and Colorectal Adenoma andCancer