A 13-Week Toxicity Study of Bismuth in Rats by Intratracheal Intermittent Administration
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概要
- 論文の詳細を見る
Although bismuth is widely used as a lead substitute in the industrial field, the toxicity of bismuth by inhalation is little known. We performed a 13-wk intratracheal intermittent bismuth dose toxicity study. Bismuth was administered at dose levels of 0, 0.8, 4, 20 mg/kg to male Crj:CD(SD)IGS rats (SPF) by intratracheal intermittent administration once a week for thirteen weeks to investigate its potential toxic effects;especially for specific adverse effects and changes related to pre-neoplastic lesions. Our results showed foreign body inflammation in the lungs, which was caused by intratracheal administration of bismuth, and physical changes related to pulmonary lesions;however, there were no serious changes in other organs. We concluded that dose-dependent, but not specific adverse effects, were attributable to bismuth inhalation in the rat.
- 社団法人日本産業衛生学会の論文
著者
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Nakashima Hiroshi
Department Of Cardiology Nagasaki Citizens Hospital
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CHIBA MOMOKO
Department of Epidemiology and Environmental Health, Juntendo University School of Medicine
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Chiba Momoko
Department Of Epidemiology And Environmental Health Juntendo University School Of Medicine
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Chiba Momoko
慶応義塾大学 医学部衛生学公衆衛生学
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Chiba Momoko
School Of Pharmaceutical Sciences International University Of Health And Welfare
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Chiba Momoko
Department Of Epidemiology And Environmental Health Juntendo University
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SATOH Hiroshi
Environmental Health Science, Tohoku University Graduate School of Medicine and Pharmaceutical Scien
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SHINOHARA Atsuko
Department of Epidemiology and Environmental Health, Juntendo University
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OMAE Kazuyuki
Department of Preventive Medicine and Public Health, School of Medicine, Keio University
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SANO Yuri
Department of Preventive Medicine and Public Health, School of Medicine, Keio University
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Shinohara Atsuko
Department Of Epidemiology And Environmental Health Department Of Internal Medicine Juntendo Univers
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OKAMOTO Masahide
Hitachi Ltd., Production Engineering Research Laboratory
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SERIZAWA Koji
Hitachi Ltd., Production Engineering Research Laboratory
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Omae Kazuyuki
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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Omae Kazuyuki
慶応義塾大学 医学部衛生学公衆衛生学
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Omae Kazuyuki
慶應義塾大学医学部衛生学公衆衛生学教室
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Omae Kazuyuki
Department Of Preventive Medicine And Public Health Keio University School Of Medicine
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Omae Kazuyuki
東京医科歯科大学難治疾患研究所 分子疫学
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Serizawa Koji
Department Of Packaging Technology Solutions Production Engineering Research Laboratory Hitachi Ltd.
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Serizawa Koji
慶応義塾大学 医学部衛生学公衆衛生学
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Shinohara Atsuko
Department Of Epidemiology And Environmental Health Juntendo University School Of Medicine
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Nakashima Hiroshi
Department Of Preventive Medicine And Public Health National Defense Medical College
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Oda Kenichi
Department Of Preventive Medicine & Public Health School Of Medicine Keio University
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Satoh Hiroshi
Environmental Health Sciences Tohoku University Graduate School Of Medicine
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Nakashima H
Hyogo University
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Nakashima Hideharu
Interdisciplinary Graduate School Of Engineering Sciences Kyushu University
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Okamoto Masahide
Department Of Packaging Technology Solutions Production Engineering Research Laboratory Hitachi Ltd.
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Sano Yuri
Department Of Preventative Medicine And Public Health School Of Medicine Keio University
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Satoh Hiroshi
Environmental Health Science Tohoku University Graduate School Of Medicine
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Satoh Hiroshi
Tohoku University Graduate School Of Medicine
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Satoh Hiroshi
Department Of Environmental Health Sciences Tohoku University School Of Medicine
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Nakashima Hiroshi
Department Of Biology Faculty Of Science Okayama University
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Omae K
慶應義塾大学医学部衛生学公衆衛生学教室
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Satoh Hiroshi
Enviromental Health Sciences Tohoku University School Of Medicine
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