Urinary Excretion of an Oxidative Stress Marker, 8-hydroxyguanine (8-OH-Gua), among Nickel-cadmium Battery Workers
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概要
- 論文の詳細を見る
The relationship between oxidative stress and carcinogenic metals including nickel and cadmium is a matter of interest. To assess the oxidative stress status of workers exposed to nickel and cadmium simultaneously, we determined urinary excretion of 8-hydroxyguanine (8-OH-Gua), a urinary oxidative stress marker. Our subjects were 66 (64 males and 2 females) nickel-cadmium battery workers. Spot urine and blood samples were collected. The levels of cadmium in blood (Cd-B) and nickel in urine (Ni-U) were determined by graphite furnace atomic absorption spectrophotometry. 8-OH-Gua in urine was analyzed using a high performance liquid chromatography-electrochemical detector (HPLC-ECD) system. Data on age, sex, duration of present work and smoking status were also obtained from each subject. Creatinine-adjusted 8-OH-Gua was significantly correlated with age, Ni-U and Cd-B in univariate analysis, while multivariate analysis revealed that Ni-U and Cd-B were significant independent variables and that these two biological exposure indices were positively correlated with 8-OH-Gua. The data were also analyzed in the context of mixture toxicity. The subjects were divided into groups based on median level of Ni-U and Cd-B (2.86 μg/g creatinine and 0.23 μg/dl, respectively). Workers with high Ni-U/high Cd-B (Group IV) had the highest levels of 8-OH-Gua levels (GM (GSD), 21.7(2.0)), followed by those with high Ni-U/low Cd-B (11.5(1.6) Group III), those with low Ni-U/high Cd-B (8.9(1.9) Group II), and those with low Ni-U/low Cd-B (8.5(1.5) Group I). The p values of Students' t-tests between Group I and Group II, III and IV were 0.847, 0.050 and <0.001, respectively. The combined effect of Cd and Ni on the urinary excretion of 8-OH-Gua departed from additivity.
- 社団法人日本産業衛生学会の論文
著者
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Nakashima Hiroshi
Department Of Cardiology Nagasaki Citizens Hospital
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YOSHIOKA Noriyuki
Department of Preventive Medicine and Public Health, School of Medicine, Keio University
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SHIMADA Naoki
Department of Preventive Medicine and Public Health, School of Medicine, Keio University
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HOSODA Kanae
Department of Preventive Medicine and Public Health, School of Medicine, Keio University
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Omae Kazuyuki
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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Omae Kazuyuki
慶応義塾大学 医学部衛生学公衆衛生学
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Omae Kazuyuki
慶應義塾大学医学部衛生学公衆衛生学教室
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Omae Kazuyuki
Department Of Preventive Medicine And Public Health Keio University School Of Medicine
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Omae Kazuyuki
東京医科歯科大学難治疾患研究所 分子疫学
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Shimada Naoki
Department Of Applied Biological Chemistry Division Of Agriculture And Agricultural Life Sciences Th
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Shimada Naoki
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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EITAKI Yoko
Osaka Occupational Health Service Center, Japan Industrial Safety and Health Association
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Nakashima Hiroshi
Department Of Preventive Medicine And Public Health National Defense Medical College
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Oda Kenichi
Department Of Preventive Medicine & Public Health School Of Medicine Keio University
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Nakashima H
Hyogo University
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Nakashima Hideharu
Interdisciplinary Graduate School Of Engineering Sciences Kyushu University
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Nishiwaki Yuji
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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Nishiwaki Yuji
Department Of Preventive Medicine And Public Health Keio University School Of Medicine
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Eitaki Yoko
Osaka Occupational Health Service Center Japan Industrial Safety And Health Association
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Hosoda Kanae
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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Nakashima Hiroshi
Department Of Cancer Therapy And Research Graduate School Of Medical Sciences Kyushu University
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Nakashima Hiroshi
Department Of Biology Faculty Of Science Okayama University
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Omae K
慶應義塾大学医学部衛生学公衆衛生学教室
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Yoshioka Noriyuki
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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