Exposure to 2, 2-Dichloro-1, 1, 1-trifluoroethane (HCFC-123) and Acute Liver Dysfunction: A Causal Inference
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概要
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Exposure to 2, 2-Dichloro-1, 1, 1-trifluoroethane (HCFC-123) and Acute Liver Dysfunction: A Causal Inference: Toru TAKEBAYASHI, et al. Department of Preventive Medicine and Public Health, School of Medicine, Keio University - Acute liver dysfunction has been reported among workers repeatedly exposed to 2, 2-dichloro-1, 1, 1-trifluoroethane (HCFC-123), a substitute for trichlorofluoromethane. Causality between occupational exposure to HCFC-123 and liver dysfunction was examined. Levels of exposure to HCFC-1223 were estimated retrospectively by reproducing working conditions and by a job record survey. Health surveillance, including liver function and subjective symptoms, was done when two workers first complained of ill health. The mean HCFC-123 concentration in air was more than 200 ppm with a peak concentration of about 1, 000 ppm in a processing area where HCFC-123 was used. HCFC-123 of 18-24 ppm was detected in the adjunct areas where HCFC-123 vapor was not generated. Workers (n=14) were then classified into high (n=5) and low (n=9) exposure groups according to the estimated exposure level, which was confirmed by determination of urinary trifluoroacetic acid. Mean serum AST and ALT levels were 236 IU/l and 476 IU/l among the high-exposed workers, and exceeded 500 IU/l in three workers. Various types of symptoms involving the central nervous system and digestive organs, and irritation of the mucous membrane, were also experienced. The degree and prevalence of these health effects were higher in the high exposure group, which indicates the exposure-effect and exposure-response relationships. The consistency and temporality of the relationship between HCFC-123 exposure and the observed health effects were also confirmed. We conclude that repeated exposure to high concentrations of HCFC-123 for no more than five weeks causes acute severe liver dysfunction with various symptoms in humans. Biological plausibility must be clarified to confirm the causality.
- 社団法人日本産業衛生学会の論文
著者
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Takebayashi T
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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TAKEBAYASHI Toru
Department of Preventive Medicine and Public Health, Keio University School of Medicine
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OMAE Kazuyuki
Department of Preventive Medicine and Public Health, School of Medicine, Keio University
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TANAKA Shigeru
Faculty of Hygienic Technology, School of Allied Health Sciences, Kitasato University
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KABE Isamu
Department of Preventive Medicine and Public Health, School of Medicine, Keio University
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MIYAUCHI Hiroyuki
The Association of Industrial Health
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NOZI Kazuko
Department of Preventive Medicine and Public Health, School of Medicine, Keio University
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TAKAHASHI Ken
Department of Preventive Medicine and Public Health, School of Medicine, Keio University
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IMAMIYA Shun-ichiro
The Association of Industrial Health
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Omae Kazuyuki
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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Omae Kazuyuki
慶応義塾大学 医学部衛生学公衆衛生学
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Omae Kazuyuki
慶應義塾大学医学部衛生学公衆衛生学教室
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Omae Kazuyuki
Department Of Preventive Medicine And Public Health Keio University School Of Medicine
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Omae Kazuyuki
東京医科歯科大学難治疾患研究所 分子疫学
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Takahashi Ken
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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Takahashi Ken
Department Of Pediatrics Juntendo University School Of Medicine
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IMAMIYA Shunichiro
The Association of Industrial Health
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TAKAHASHI Ken
University of Occupational and Environmental Health
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Takebayashi Toru
Department Of Preventive Medicine And Public Health Keio University School Of Medicine
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Nozi Kazuko
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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Oda Kenichi
Department Of Preventive Medicine & Public Health School Of Medicine Keio University
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Hirata Miyuki
Department Of Hygiene Graduate School Of Medical Sciences Kyushu University
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Takahashi Ken
Japan Industrial Safety And Health Association
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Endo Y
Japan Soc. For Occupational Health
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Yamauchi Tuneyuki
Occupational Health Research And Development Center Japan Industrial Safety And Health Association:j
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Kabe Isamu
Department Of Preventive Medicine And Public Health School Of Medicine Keio University:department Of
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Tanaka Shigeru
Department Of Public Health School Of Human Life Sciences Jumonji University
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Takahashi K
Dep. Of Environmental Epidemiology Inst. Of Industrial Ecological Sciences Univ. Of Occupational And
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Takahashi Ken
Department Of Pediatrics And Adolescent Medicine Juntendo University School Of Medicine
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Takahashi Ken
Department Of Cardiology Tokyo Women's Medical University
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Takahashi Ken
Department Of Applied Chemistry And Molecular Science Faculty Of Engineering Iwate University
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Endo Yu′ichi
Department of Preventive Medicine and Public Health, School of Medicine, Keio University
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Takebayashi Toru
Department of Health Sciences, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
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