A Cross-Sectional Observation of the Effects of Hydrazine Hydrate on Workers' Health

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• A Cross-Sectional Observation of the Effects of Hydrazine Hydrate on Workers' Health : Tetsuo NOMIYAMA, et al. Department of Preventive Medicine and Public Health, School of Medicine, Keio University-Objective : To clarify the current and cumulative effects of hydrazine hydrate (HH)(N_2H_4・H_2O:CAS No.7803-57-8) on workers' health. Methods : A cross-sectional survey was carried out on 172 male HH-exposed workers (age 18-60, mean 39.6 ; exposure duration 0.50-34.17) and 125 male referent workers (age 19-58, mean 40.9) at 5 factories making HH or hydrazine derivatives in Japan. Current exposure concentrations were assessed by determining hydrazine in the breathing zones and urinary hydrazine + acetylhydrazine. The cumulative exposure level was assessed by multiplying the individuals' working durations at the job sites and the estimated past environmental levels at the job sites. Clinical examinations were performed with particular focus on hepatic and renal function tests. N-acetyltransferase (NAT2) phenotypes were assessed. Acute and chronic subjective symptoms related to HH were examined by self-administered questionnaires. Results : No hydrazine was detected in either the breathing zones or the urine of the referent workers. The mean hydrazine concentration in the breathing zones, hydrazine + acetylhydrazine in urine, and cumulative exposure level were 0.0109 ppm (N.D.-0.2003), 0.8660 μmol/g・Cr(N.D.-14.20), and 2.80 ppm-years (0.003-19) respectively. There was no difference and no dose-dependent change in either the means or the prevalence abnormal findings in health examination items between the HH-exposed and the referent workers after adjusting confounding factors and by means of the differences of NAT2 phenotypes. Among 90 subjective symptoms, complaint of "nightmares" was significantly related to HH exposure. Conclusion : In this study, no health effect regarding current and cumulative HH exposure was observed in the HH-exposed workers when compared to the referent workers.

• 社団法人日本産業衛生学会の論文

著者

• NOMIYAMA Tetsuo

  Department of Preventive Medicine and Public Health,School of Medicine,Keio University

• SAKURAI Haruhiko

  Department of Preventive Medicine and Public Health,School of Medicine,Keio University

• SAKURAI Haruhiko

  Occupational Health Research and Development Center, Japan Industrial Safety and Health Association

• TANAKA Shigeru

  Faculty of Hygienic Technology, School of Allied Health Sciences, Kitasato University

• MIYAUCHI Hiroyuki

  The Association of Industrial Health

• Omae Kazuyuki

  Department Of Preventive Medicine And Public Health School Of Medicine Keio University

• Omae Kazuyuki

  慶応義塾大学 医学部衛生学公衆衛生学

• Omae Kazuyuki

  慶應義塾大学医学部衛生学公衆衛生学教室

• Omae Kazuyuki

  Department Of Preventive Medicine And Public Health Keio University School Of Medicine

• Omae Kazuyuki

  東京医科歯科大学難治疾患研究所 分子疫学

• Nomiyama T

  Division Of Environmental Medicine Department Of Preventive Medicine School Of Medicine Shinshu Univ

• Nomiyama Tetsuo

  Department Of Preventive Medicine Shinshu University School Of Medicine

• Koizumi A

  Kyoto Univ. Kyoto Jpn

• Aoki Kunio

  Department Of Health And Environmental Sciences Kyoto University Graduate School Of Medicine

• Koizumi Akio

  秋田大学 衛生

• Koizumi Akio

  Department Of Hygiene Yamaguchi University School Of Medicinemedicine

• WADA Yasuhiko

  Department of Clinical Informatics, Kansai Rosai Hospital

• Koizumi Akio

  Department Of Health And Environmental Sciences Graduate School Of Medicine Kyoto University

• Wada Yasuhiro

  Department Of Hygiene Akita University School Of Medicine

• MOGI Takashi

  Department of Hygiene,Akita University School of Medicine

• TSUKADA Mikako

  Department of Hygiene, School of Medicine, Akita University

• IMAMIYA Shunichiro

  The Association of Industrial Health

• WADA Yasuhiko

  Hyogo College of Medicine

• Koizumi Akio

  Department Of Health And Environmental Science School Of Public Health Kyoto University

• Wada Yasuhiko

  Japan Labour Health And Welfare Organization Kansai Rosai Hospital

• Oda Kenichi

  Department Of Preventive Medicine & Public Health School Of Medicine Keio University

• Hirata Miyuki

  Department Of Hygiene Graduate School Of Medical Sciences Kyushu University

• Tsukada Mikako

  Department Of Hygiene School Of Medicine Akita University

• Tsukada Mikako

  Department Of Hygiene Akita University School Of Medicine

• Endo Y

  Japan Soc. For Occupational Health

• Sakurai H

  Showa Univ. Tokyo Jpn

• Sakurai Haruhiko

  Occupational Health Research And Development Center Japan Industrial Health Association

• Sakurai Haruhiko

  Department Of Cardiology Toki General Hospital

• Yamauchi Tuneyuki

  Occupational Health Research And Development Center Japan Industrial Safety And Health Association:j

• Wada Yasuhiko

  Department Of Clinical Informatics Kansai Rosai Hospital

• Mogi Takashi

  Department Of Hygiene School Of Medicine Akita University

• Wada Yasuhiko

  Department Of Civil And Environmental Engineering

• Tanaka Shigeru

  Department Of Public Health School Of Human Life Sciences Jumonji University

• Watanabe Yoshiyuki

  Department Of Epidemiology For Community Health And Medicine Kyoto Prefectural University Of Medicin

• NOMIYAMA Tetsuo

  Department of Preventive Medicine and Public Health, Shinshu University School of Medicine

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