A Linear Pharmacokinetic Model Predicts Usefulness of N-Methyl-2-Pyrrolidone (NMP) in Plasma or Urine as a Biomarker for Biological Monitoring for NMP Exposure

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概要

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• N-methyl-2-pyrrolidone (NMP:C_5H_9NO:CAS number 872-50-4) is an increasingly used solvent due to the lack of ozone depleting activity. The aim of this study is to construct a simple pharmacokinetic model for NMP. In factory A, four workers who were exposed to NMP at 0.09-0.69 ppm for 12 h by time weighted average (TWA) were followed up for an entire workweek. Their NMP concentrations in plasma and urine were monitored during the observation period. Five volunteers were exposed to NMP during the observation of workers in the factory A for eight hours. NMP kinetics in plasma and urine were monitored for 2 d after exposure. Concentrations of NMP in plasma and urine as standardized by creatinine concentrations were used to construct a one compartment pharmacokinetic model. The model successfully simulated the kinetics in four workers and five volunteers. In the next step, the model was applied to eight workers in another factory : they were exposed to NMP for 12 h at 0.04 to 0.59 ppm by TWA. The model could successfully predict kinetics of NMP levels in plasma and urine at the end of work. The model was then applied to experimental exposure cases in the literature. The model successfully predicted the concentrations of NMP in plasma and urine at the exposure intensity level of 12 ppm×8 h. These results imply that metabolic saturation does not occur up to the exposure intensity of 12 ppm×8 h and demonstrate the usefulness of determinations of NMP in plasma and urine for biological monitoring.

• 社団法人日本産業衛生学会の論文

著者

• MIYAUCHI Hiroyuki

  The Association of Industrial Health

• Koizumi A

  Kyoto Univ. Kyoto Jpn

• Aoki Kunio

  Department Of Health And Environmental Sciences Kyoto University Graduate School Of Medicine

• Koizumi Akio

  秋田大学 衛生

• Koizumi Akio

  Department Of Hygiene Yamaguchi University School Of Medicinemedicine

• WADA Yasuhiko

  Department of Clinical Informatics, Kansai Rosai Hospital

• Koizumi Akio

  Department Of Health And Environmental Sciences Graduate School Of Medicine Kyoto University

• NOZAKI JUN-ICHI

  Graduate School of Medicine, Department of Health and Environment Sciences, Kyoto University

• Wada Yasuhiro

  Department Of Hygiene Akita University School Of Medicine

• TANAKA Shigeru

  Schoool of Allied Health Sciences, Kitasato University

• SEKI Yukio

  Schoool of Allied Health Sciences, Kitasato University

• WADA Yasuhiko

  Hyogo College of Medicine

• E Xiaofei

  Department of Hygiene, Akita University School of Medicine

• Nozaki Jun-ichi

  Department of Hygiene, Akita University School of Medicine

• Koizumi Akio

  Department Of Health And Environmental Science School Of Public Health Kyoto University

• Wada Yasuhiko

  Japan Labour Health And Welfare Organization Kansai Rosai Hospital

• E Xiaofei

  Department Of Hygiene Akita University School Of Medicine

• Seki Y

  Schoool Of Allied Health Sciences Kitasato University

• Seki Yukio

  School Of Allied Health Sciences Kitasato University

• Hirata Miyuki

  Department Of Hygiene Graduate School Of Medical Sciences Kyushu University

• Endo Y

  Japan Soc. For Occupational Health

• Yamauchi Tuneyuki

  Occupational Health Research And Development Center Japan Industrial Safety And Health Association:j

• Wada Yasuhiko

  Department Of Clinical Informatics Kansai Rosai Hospital

• Wada Yasuhiko

  Department Of Civil And Environmental Engineering

• Tanaka Shigeru

  Department Of Public Health School Of Human Life Sciences Jumonji University

• Nozaki Jun-ichi

  Department Of Hygiene Akita University School Of Medicine:department Of Health And Environmental Sci

• Watanabe Yoshiyuki

  Department Of Epidemiology For Community Health And Medicine Kyoto Prefectural University Of Medicin

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