Negative Results of umu Genotoxicity Test of Fluorotelomer Alcohols and Perfluorinated Alkyl Acids
スポンサーリンク
概要
- 論文の詳細を見る
Objectives : Recently, perfluorooctanoate (PFOA) has been ubiquitously detected in the environment as well as in human serum. Fluorotelomer alcohols (FTOHs), a precursor of PFOA, undergo biodegradation via several metabolic routes which leads to formation of various biodegradation products. The degradation of FTOHs produces and α, β-unsaturated aldehyde that seems possibly to be electrophilic and may react with cellular macromolecules including DNA. Methods : We investigated the genotoxicity of three FTOHs (6 : 2 FTOH, 8 : 2 FTOH and 10 : 2 FTOH), PFOA and perfluorooctane sulfonate (PFOS) using the umu test. Results : The FTOHs, PFOA and PFOS showed no significant increases in β-galactosidase activity at 0-1000 μM in the absence of S9 mix. The results were unchanged by the metabolic activation with S9 mix. Conclusion : The genotoxicities of FTOHs, PFOA or PFOS are not detectable using the present method, suggesting that they are unlikely mutagens.
- 日本衛生学会の論文
著者
-
Oda Yoshimitsu
Osaka Prefectural Institute of Public Health
-
Koizumi Akio
Department Of Hygiene Yamaguchi University School Of Medicinemedicine
-
HARADA Kouji
Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University
-
Koizumi Akio
Department Of Health And Environmental Sciences Kyoto University Graduate School Of Medicine
-
NAKAYAMA Shoji
Department of Public Health, Okayama University Medical School
-
Nakayama Shoji
Department Of Health And Environmental Sciences Kyoto University Graduate School Of Medicine
-
Koizumi Akio
Department Of Health And Environmental Science School Of Public Health Kyoto University
-
Harada Kouji
Kyoto Univ. Graduate School Of Medicine Kyoto Jpn
-
Harada Kouji
Department Of Computer Science & Electronic Engineering Tokuyama College Of Technology
-
Oda Y
Osaka Prefectural Institute Of Public Health
関連論文
- Genotoxic Activation of the Environmental Pollutant 3-Nitrobenzanthrone by Human Cytochrome P450 Enzymes Expressed in Salmonella typhimurium umu Tester Strains
- Evaluation of the Efficiency of Respiratory Protective Equipment based on the Biological Monitoring of Styrene in Fibreglass Reinforced Plastics Industries
- Risk and Protective Factors Related to Mortality from Pneumonia among Middle-aged and Elderly Community Residents : The JACC Study
- Relationships of Age at Menarche and Menopause, and Reproductive Year with Mortality from Cardiovascular Disease in Japanese Postmenopausal Women : The JACC Study
- Antimutagenic Compound from Yellow batai (Peltophorum dasyrachis)
- Nephronophthisis complicated with hepatic fibrosis : an autopsy case with rupture of the splenic artery after renal transplantation
- Past, present, and future of environmental specimen banks
- A rare Asian founder polymorphism of Raptor may explain the high prevalence of Moyamoya disease among East Asians and its low prevalence among Caucasians
- Environmental and biological monitoring of persistent fluorinated compounds in Japan and their toxicities
- Proposal of a new editorial policy for EHPM and Nippon Eiseigaku Zasshi
- Reconstruction of human exposure to heavy metals using synchrotron radiation microbeams in prehistoric and modern humans
- Association analyses confirming a susceptibility locus for intracranial aneurysm at chromosome 14q23
- Historical Trends in Human Serum Levels of Perfluorooctanoate and Perfluorooctane Sulfonate in Shenyang, China
- A Nonsense Polymorphism (Y319X) of the Solute Carrier Family 6 Member 18 (SLC6A18) Gene is Not Associated with Hypertension and Blood Pressure in Japanese
- Perfluorooctanoate and Perfluorooctane Sulfonate Concentrations in Surface Water in Japan
- Epidemiological study on hypoglycemia endemic to female nursesand other workers
- An endemic conditon of biochemical hypoglycemia among malevolunteers
- Genotoxicity and mutational specificity induced by aminophenylnorharman and related heterocyclic amines.(GENERAL SESSION BY ORAL PRESENTATION)(GENOTOXICITY)
- A Cross-Sectional Observation of the Effects of Hydrazine Hydrate on Workers' Health
- O11-13 Role of human P450 enzymes in the metabolic activation of carcinogenic aromatie amines.
- P-70(O-7) Development of new umu tester strain expressing human NADPH-P450 reductase and P450 1A2 involved in bioactivation of aromatic amines
- Paradoxical increases in serum levels of highly chlorinated PCBs in aged women in clear contrast to robust decreases in dietary intakes from 1980 to 2003 in Japan
- Secular Trends and Geographical Variations in the Dietary Intake of Polybrominated biphenyl Ethers (PBDEs) Using Archived Samples from the Early 1980s and Mid 1990s in Japan
- The Influence of Time, Sex and Geographic Factors on Levels of Perfluorooctane Sulfonate and Perfluorooctanoate in Human Serum over the Last 25 years
- Use of Material Safety Data Sheets at Workplaces Handling Harmful Substances in Okayama, Japan
- Utilization of a Voluntary Reporting System in Quantitative Risk Assessment for Medical Tasks in a Hospital Settinga-with Special Reference to Tasks Done by Nurses
- A Linear Pharmacokinetic Model Predicts Usefulness of N-Methyl-2-Pyrrolidone (NMP) in Plasma or Urine as a Biomarker for Biological Monitoring for NMP Exposure
- Heterogeneity of N-Acetyltransferase Genotype among Japanese in the Tohoku District
- A Mouse model of a sudden death Induced by Noise Exposure is Useful to Investigate Human Responses to Physical Stress
- Complications of IgA Nephropathy in a Non-Insulin-Dependent Diabetes Model, the Akita Mouse
- Suppression of Experimental Autoimmune Uveoretinitis by Dietary Calorie Restriction
- Changes in Nitric Oxide Synthase Activities in the Cerebellum during Development and Aging of C57BL/6 Mice
- Evidence for an Acceleration of Programmed Cell Death in Bronchilar Epithelium after Exposure to O, O, S-Trimethyl Phosphorothioate
- Probable involvement of a germ-line mutation of an unknown mismatch repair gene in a Japanese Muir-Torre syndrome phenotype
- Negative Results of umu Genotoxicity Test of Fluorotelomer Alcohols and Perfluorinated Alkyl Acids
- Log-Normality of Air Contaminants and Its Hidden Characteristics Useful for Industrial Hygiene Technology
- Construction of Green Fluorescent Protein Reporter Genes for Genotoxicity Test(SOS/umu-Test)and Improvement of Mutagen-Sensitivity
- 3A-10 Metabolic activation of nitroarenes and aromatic amines by human NAT1 and NAT2 N-acetyltransferases using umu test system
- O-16 Detection of CarcinogenicAromatic Amines Using Umu Tester Strains Endogenously Expressing Human Cytochrome P450 1A2 and NADH-P450 Reductase, and/or Bacterial O-Acetyltransferase.(Proceedings of the 27th Annual Meeting)
- Metabolic Activation of Aromatic Amine Bladder Carcinogens by Human N-Acetyltransferase Enzyme Expressed in Bacterial SOS/umu Test System
- O-19 Metabolic activation of 3-nitobenzanthrone by the human recombinant cytochrome P450 and acetyltransferase(MUTAGENICITY)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)
- History of blood transfusion before 1990 is associated with increased risk for cancer mortality independently of liver disease : a prospective long-term follow-up study
- The Roles of Phase Transition in Multi-Agent Performance Regulation(Software Agent and Its Applications)
- A Novel Endogenous Mouse Mammary Tumor Virus Locus in Asian Wild Mice and Its Evolutionary Divergency
- Phenotypical variety of insulin resistance in a family with a novel mutation of the insulin receptor gene
- Usefulness of a large automated health records database in pharmacoepidemiology
- Distribution of Moyamoya Disease Susceptibility Polymorphism p.R4810K in RNF213 in East and Southeast Asian Populations
- Tubulointerstitial damage as the major pathological lesion in endemic chronic kidney disease among farmers in North Central Province of Sri Lanka
- Risk factors associated with disease progression and mortality in chronic kidney disease of uncertain etiology : a cohort study in Medawachchiya, Sri Lanka
- Evidence of tubular damage in the very early stage of chronic kidney disease of uncertain etiology in the North Central Province of Sri Lanka : a cross-sectional study
- Screening for Antibodies to Human T-Cell Leukemia Virus Type I in Japanese Breast Milk
- Preliminary assessment of ecological exposure of adult residents in Fukushima Prefecture to radioactive cesium through ingestion and inhalation
- A Prospective Cohort Study of Employment Status and Mortality from Circulatory Disorders among Japanese Workers
- A Commentary on genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms
- BENTONITE FLOCCULATION TEST AND LATEX FIXATION TEST SLIDE METHOD