Antimutagenic Compound from Yellow batai (Peltophorum dasyrachis)

スポンサーリンク

概要

• 論文の詳細を見る

• A ethanol extract from Yellow batai (Peltophorum dasyrachis) showed a suppressive effect on umu gene expression of SOS response in Salmonella typhimurium OY1001/1A2 against the mutagen 2-amino-3,4-dimethylimidazo[4,5-f ]quinoline (MeIQ). The ethanol exract was re-extracted with chloroform, ethylacetate, butanol, and water. A chloroform fraction showed a suppressive effect. Suppressive compound against MeIQ in the chloroform fraction was isolated by SiO2 column chromatography and identified as surangin C (1) by FABMS, EIMS, and 1 D and 2 D NMR spectroscopy. Surangin C exhibited an inhibition of the SOS-inducing activity of MeIQ in the umu test. Gene expression was suppressed 59.5% at a concentration of 100 μM. The ID50 value (50% inhibition dose) of compound 1 was 67.9 μM. On the other hand, compound 1 showed weak suppressive effects of the SOS-inducing activity on activated MeIQ.

• 日本油化学会の論文

著者

• Oda Yoshimitsu

  Osaka Prefectural Institute of Public Health

• MIYAZAWA Mitsuo

  Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University

• OKUNO Yoshiharu

  Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University

• Okuno Yoshiharu

  Department Of Applied Chemistry Faculty Of Science And Engineering Kinki University

• Yagi Nobuo

  Picaso Cosmetic Laboratory Limited

• Ohkubo Katsuya

  Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University

• Miyazawa Mitsuo

  Department Of Applied Chemistry Faculty Of Scienc Snd Engineering Kinki University

• Miyazawa Mitsuo

  Department Of Aplied Chemistry Faculty Of Science And Engineering Kinki University

関連論文

• Genotoxic Activation of the Environmental Pollutant 3-Nitrobenzanthrone by Human Cytochrome P450 Enzymes Expressed in Salmonella typhimurium umu Tester Strains
• Inhibition of Helicobacter pylori Motility by (+)-Syringaresinol from Unripe Japanese Apricot(Medicinal Chemistry)
• Endoscopic pancreatic duct drainage and stenting for acute pancreatitis and pancreatic cyst and abscess
• Metabolism of (+)- and (-)-Menthols by CYP2A6 in Human Liver Microsomes
• Volatile Components of the Straw of Oryza sativa L.
• Comparison of Larvicidal, Adulticidal and Acaricidal Activity of Two Geometrical Butylidenephthalide Isomers(Pharmacognosy)
• Biotransformation of (-)-Menthone by Human Liver Microsomes
• Volatile Flavor Components of ZINGIBERIS RHIZOMA (Zingiber officinale Roscoe)(Organic Chemistry)
• 炭疽病菌による4-propylcyclohexanoneおよび4-isopropylcyclohexanoneの立体選択的還元
• 炭疽病菌による4-tert-butylcyclohexanoneの立体選択的還元
• Essential Oil Constituents of "PAEONIAE RADIX" Peaonia lactiflora Pall. (P. albilora Pall.)
• The Constituents of the Essential Oil from Erigeron philadelphicus
• Convenient Synthesis of Arylmethylenesuccinic Acids via Wittig Reaction
• Character Impact Odorants of Wild Edible Plant-Cacalia hastata L. var. orientalis-Used in Japanese Traditional Food
• Hepatic Metastasis 12 Years after Nephrectomy for Renal Cell Carcinoma
• Inhibitory Compound of Tyrosinase Activity from the Sprout of Polygonum hydropiper L.(Benitade)(Pharmacology)
• Regioselective Oxidation of (+)-α-Longipinene by Aspergillus niger
• Cyclooxygenase-2 inhibitory effects and composition of the volatile oil from the dried roots of Lithospermum erythrorhizon
• Constituents of Essential Oil from the Dried Fruits and Stems of Akebia quinata (THUNB.) DECNE.
• Suppression of the SOS-Inducing Activity of Trp-P-1 and Aflatoxin B_1 by Meso-dihydroguaiaretic Acid from Machilus thunbergii in the Salmonella typhimurium TA1535/pSK1002 umu Test
• Biotransformation of Sinesetin by the Larvae of the Common Cutworm (Spodoptera litura)(Biochemistry/Molecular Biology)
• α-Glucosidase Inhibitor from Bergenia ligulata
• Antimutagenic Compound from Yellow batai (Peltophorum dasyrachis)
• Components of Essential Oil from Woods of Prunus mume Sieb. et Zucc.
• Antimutagenic Activity of Isoflavone from Belamcanda chinensis
• Antimutagenic Activity of Gigantol from Dendrobium nobile
• Antimutagenic Activity of Falcarindiol from Peucedanum praeruptorum
• Antimutagenic Activity of (+)-β-Eudesmol and Paeonol from Dioscorea japonica
• Antimutagenic Activity of Flavonoids from Chrysanthemum morifolium(Biochemistry & Molecular Biology)
• Suppression of Chemical Mutagens-Induced SOS Response by Phenolic Acids from Black Rice Bran Using Salmonella typhimurium TA1535/pSK1002 umu Test
• PB113 SYNTHESIS AND BIOLOGICAL ACTIVITY OF β-D-GLUCOPYRANOSIDE OF THE MONOTERPENE ALCOHOLS
• Genotoxicity and mutational specificity induced by aminophenylnorharman and related heterocyclic amines.(GENERAL SESSION BY ORAL PRESENTATION)(GENOTOXICITY)
• O11-13 Role of human P450 enzymes in the metabolic activation of carcinogenic aromatie amines.
• P-70(O-7) Development of new umu tester strain expressing human NADPH-P450 reductase and P450 1A2 involved in bioactivation of aromatic amines
• Characterization of Volatile Aroma Compounds from Red and Black Rice Bran
• Species Differences in the Metabolism of (+)-and (-)-Limonenes and their Metabolites, Carveols and Carvones, by Cytochrome P450 Enzymes in Liver Microsomes of Mice, Rats, Guinea Pigs, Rabbits, Dogs, Monkeys, and Humans
• Volatile Flavor Components of ASTRAGALI RADIX (Astragalus membranaceus Bunge)(Organic Chemistry)
• Suppression of SOS-Inducing Activity of Chemical Mutagens by Yakuchinone A from Alpinia oxyphylla in the Salmonella typhimurium TA1535/pSK1002 umu Test
• The Novel Assay Method for Nicotine Metabolism to Cotinine Using High Performance Liquid Chromatography
• Inhibitory Compounds of α-Glucosidase Activity from Arctium lappa L.
• Negative Results of umu Genotoxicity Test of Fluorotelomer Alcohols and Perfluorinated Alkyl Acids
• Identification of the Key Aroma Compounds in Dried Roots of Rubia cordifolia
• Biotransformation of Geraniol by the Larvae of Common Cutworm (Spodoptera litura)
• Use of Solid Phase Microextraction (SPME) for Profiling the Volatile Metabolites Produced by Glomerella cingulata
• Microbial Transformation of (-)-Isolongifolol by Plant Pathogenic Fungus Glomerella cingulata
• Influence of Root Exudates from Cucumis sativus and Daucus carota on Arbuscular Mycorrhizal Colonization
• Contractile and Extensile Effects of Red and White Wine on Rat and Mongolian gerbil Gastrointestinal Smooth Muscle
• Identification of the main aroma compounds in dried seeds of Brassica hirta
• A Useful Synthesis of Alkylidenesuccinic Acids by Wittig Reaction in Aqueous Media
• Construction of Green Fluorescent Protein Reporter Genes for Genotoxicity Test(SOS/umu-Test)and Improvement of Mutagen-Sensitivity
• High-performance liquid chromatographic method for the determination of (-)-verbenone 10-hydroxylation catalyzed by rat liver microsomes
• Biotransformation of (-)-Verbenone by Human Liver Microsomes(Food & Nutrition Science)
• 3A-10 Metabolic activation of nitroarenes and aromatic amines by human NAT1 and NAT2 N-acetyltransferases using umu test system
• O-16 Detection of CarcinogenicAromatic Amines Using Umu Tester Strains Endogenously Expressing Human Cytochrome P450 1A2 and NADH-P450 Reductase, and/or Bacterial O-Acetyltransferase.(Proceedings of the 27th Annual Meeting)
• Metabolic Activation of Aromatic Amine Bladder Carcinogens by Human N-Acetyltransferase Enzyme Expressed in Bacterial SOS/umu Test System
• O-19 Metabolic activation of 3-nitobenzanthrone by the human recombinant cytochrome P450 and acetyltransferase(MUTAGENICITY)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)
• Synthesis and Characterization of New Ascorbic Derivative: Sodium Isostearyl 2-O-L-Ascorbyl Phosphate
• Chemical Composition of Volatile Oil from the Roots of Periploca sepium
• Biotransformation of (-)-Camphor by Salmonella typhimurium OY1002/2A6 Expressing Human CYP2A6 and NADPH-P450 Reductase
• Volatile Flavor Components of SINOMENI CAULIS ET RHIZOMA (Sinomenium acutum Rehder et Wilson)(Organic Chemistry)
• Volatile Flavor Components of PUERARIAE RADIX (Pueraria lobata Ohwi)(Organic Chemistry)
• Volatile Flavor Components of CORNI FRUCTUS (Cornus officinalis Sieb. et Zucc.)(Organic Chemistry)
• Preoperative 18[F]-fluorodeoxyglucose positron emission tomography/computed tomography predicts early recurrence after pancreatic cancer resection
• Biotransformation of Isoflavones by the Larvae of the Common Cutworm (Spodoptera litura)
• Components of the Essential Oil from Matteuccia struthiopteris
• In Vitro Metabolism of (-)-Camphor Using Human Liver Microsomes and CYP2A6(Biochemistry)
• Reduction of Oxazepam to Desmethyldiazepam by Human Intestinal Bacteria
• Components of Essential Oil from Rootstock of Coptis chinensis
• A Prunus mume Extract Stimulated the Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells
• Components of Essential Oil from Rootstock of Coptis chinensis
• Microbial Transformation of Isopimpinellin by Glomerella cingulata
• A Prunus mume Extract Stimulated the Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells
• Metabolism of (+)-Fenchone by CYP2A6 and CYP2B6 in Human Liver Microsomes(Biochemistry)
• Biotransformation of (-)-Dihydromyrcenol and (-)-Dihydromyrcenyl Acetate by the Larvae of Common Cutworm (Spodoptera litura)
• Metabolism of (+)-Terpinen-4-ol by Cytochrome P450 Enzymes in Human Liver Microsomes
• Quantitative Evaluation of (+)-.DELTA.3-Carene Metabolites from Living Larvae of Spodoptera litura by Headspace Solid-phase Microextraction
• Regeneration of extrahepatic bile ducts by tissue engineering with a bioabsorbable polymer
• Analysis of Volatile Organic Compounds Emitted by Plant Growth-Promoting Fungus Phoma sp. GS8-3 for Growth Promotion Effects on Tobacco

もっと見る 閉じる

スポンサーリンク