Contractile and Extensile Effects of Red and White Wine on Rat and Mongolian gerbil Gastrointestinal Smooth Muscle

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概要

• 論文の詳細を見る

• The contractile and extensile effects of red and white wine on rat and Mongolian gerbil (gerbil) gastrointestinal smooth muscle were investigated. Both wines elicited contractile responses on rat and gerbil duodenum and ileum but had no such effects on the colon or rectum. Dichloromethane extracts derived from either wine showed extensile responses only on rat duodenum and ileum, and did not elicit extensile effects on the colon or rectum. In contrast, wine dichloromethane extracts did not elicit any extensile effects on either gerbil duodenum or ileum. Moreover, dichloromethane extracts had suppressive effects on acetylcholine-induced contractile responses. Red and white wine has been documented to contain a number of organic acids such as tartaric, malic, lactic, and citric acid. Individually, such compounds evoked contractile response on rat duodenum with an order of contractile potency; citric 〉 tartaric ≥ malic 〉 lactic acid. The abundance of such compounds in either wine implicates them as the active component responsible for gastrointestinal smooth muscle responses.

• 日本油化学会の論文

著者

• MIYAZAWA Mitsuo

  Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University

• MINESHITA SATORU

  Department of Preventive Medicine, Division of Social Medicine, Medical Research Institute, Tokyo Me

• Miyazawa Mitsuo

  Department Of Applied Chemistry Faculty Of Scienc Snd Engineering Kinki University

• KINJO Noriko

  Department of General Education, Tokyo Medical and Dental University

• Shimamura Hideo

  Research and Development Center, Fuso Pharmaceutical Industries, Ltd.

• Hirota Mikako

  Faculty of Pharmaceutical Sciences, Teikyo Heisei University

• Kinjo Noriko

  Department Of General Education Tokyo Medical And Dental University

• Mineshita Satoru

  Department Of Preventive Medicine Medical Research Institute Tokyo Medical And Dental University

• Miyazawa Mitsuo

  Department Of Aplied Chemistry Faculty Of Science And Engineering Kinki University

• Mineshita Satoru

  Department Of Medicine Funado Hospital

• Hirota Mikako

  Faculty Of Pharmaceutical Sciences Teikyo Heisei University

• Kinjo Noriko

  Department of Biology, College of Liberal Arts and Sciences, Tokyo Medical and Dental University

• MINESHITA Satoru

  Department of Clinical Pharmacology, Medical Research Institute, Tokyo Medical and Dental University

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