Suppression of SOS-Inducing Activity of Chemical Mutagens by Yakuchinone A from Alpinia oxyphylla in the Salmonella typhimurium TA1535/pSK1002 umu Test

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概要

• 論文の詳細を見る

• The methanol extract from Alpinia oxyphylla showed a suppressive effect on umu gene expression of SOS response in Salmonella typhimurium TA1535/pSK1002 against the mutagen 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (furylfuramide). The methanol extract from A. oxyphylla was successively re-extracted with CH2Cl2, EtOAc, BuOH, and water. A dichloromethane fraction showed a suppressive effect. The suppressive compound in the dichloromethane fraction was isolated by SiO2 column chromatography and identified as yakuchinone A(1) by GC, GC/MS, 1H and 13C NMR spectroscopy. Compound 1 suppressed the SOS-inducing activity of furylfuramide in the umu test. Compound 1 suppressed 51.7% of the SOS-inducing activity at a concentration of 0.32μM/mL. The ID50 value (50% inhibition dose) of compound 1 was 0.30μM/mL. This compound was assayed with an other mutagen, 3-amino-14-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), which requires a liver metabolizing enzyme, activated Trp-P-1.

• 日本油化学会の論文
• 2001-06-01

著者

• MIYAZAWA Mitsuo

  Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University

• Miyazawa M

  Kinki Univ. Osaka Jpn

• Nakamura Yuji

  Department of Pharmacology, School of Medicine, Toho University, Japan

• SAKANO Katsuhisa

  Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University

• NAKAMURA Sei-ichi

  Osaka Prefectural Institute of Public Healthy

• KOSAKA Hiroshi

  Osaka Prefectural Institute of Public Healthy

• Miyazawa Mitsuo

  Department Of Applied Chemistry Faculty Of Scienc Snd Engineering Kinki University

• Nakamura Sei-ichi

  Osaka Prefectural Institute Of Public Health

• Kameoka Hiromu

  Osaka Prefectural Institute Of Public Healthy

• Kosaka H

  Osaka Prefectural Institute Of Public Health

• Nakamura Yuji

  Department Of Materials Engineering Graduate School Of Engineering The University Of Tokyo:crest Jap

• Sakano Katsuhisa

  Department Of Applied Chemistry Faculty Of Scienc Snd Engineering Kinki University

• Miyazawa Mitsuo

  Department Of Aplied Chemistry Faculty Of Science And Engineering Kinki University

• Nakamura Yuji

  Department Of Anesthesiology Shimane Medical University

• Nakamura Yuji

  Department Of Agricultural Chemistry Faculty Of Agriculture Kyushu University

• Nakamura Yuji

  Department Of Applied Chemistry Faculty Of Scienc Snd Engineering Kinki University

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