Synthesis and Characterization of New Ascorbic Derivative: Sodium Isostearyl 2-O-L-Ascorbyl Phosphate
スポンサーリンク
概要
- 論文の詳細を見る
A novel alkyl ester of Vitamin C derivative, originated in a stable ascorbate derivative, sodium L-ascorbic acid 2-phosphate (VCP-Na), was chemically synthesized. The thermal stability, surface tension, distribution between organic and water phase, and in vitro skin permeability were evaluated. This monoalkyl ester derivative was identified as sodium isostearyl 2-O-L-ascorbyl phosphate (VCP-IS-Na) by UV spectra, infrared spectra, mass spectra, and nuclear magnetic resonance spectroscopy. The reaction afforded VCP-IS-Na in a high yield (60%). VCP-IS-Na exhibited satisfactory stability in neutral solution comparable to that of a typical stable derivative, VCP-Na. Increased skin permeability was superior to those of VCP-Na and ascorbic acid (VC). VCP-IS-Na that is susceptible to the enzymatic hydrolysis by tissue esterase and/or phosphatase released VC in the skin tissues. Thus, these characteristics indicate that the novel Vitamin C derivative presented here, VCP-IS-Na, may be effective pro-Vitamin C for skin care application.
- 日本油化学会の論文
著者
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Hisama Masayoshi
Central Research Center, Toyo Beauty Co., Ltd.
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Matsuda Sanae
Central Research Center, Toyo Beauty Co., Ltd.
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Shibayama Hiroharu
Central Research Center, Toyo Beauty Co., Ltd.
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MIYAZAWA Mitsuo
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
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UEDA Koichi
Central Research Center Research & Development Division, Toyo Beauty Co., Ltd.
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YOSHIO Kimio
Central Research Center Research & Development Division, Toyo Beauty Co., Ltd.
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Shibayama Hiroharu
Hbc Science Research Center Co. Ltd.
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Miyazawa Mitsuo
Department Of Aplied Chemistry Faculty Of Science And Engineering Kinki University
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HISAMA Masayoshi
Central Research Center Research & Development Division, Toyo Beauty Co., Ltd.
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MATSUDA Sanae
Central Research Center Research & Development Division, Toyo Beauty Co., Ltd.
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UEDA Koichi
Central Research Center Research & Development Division, Toyo Beauty Co., Ltd.
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YOSHIO Kimio
Central Research Center Research & Development Division, Toyo Beauty Co., Ltd.
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SHIBAYAMA Hiroharu
Central Research Center Research & Development Division, Toyo Beauty Co., Ltd.
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