Effect of a Novel Ascorbic Derivative, Disodium Isostearyl 2-O-L-Ascorbyl Phosphate, on Normal Human Dermal Fibroblasts against Reactive Oxygen Species
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概要
- 論文の詳細を見る
The novel amphiphilic vitamin C derivative disodium isostearyl 2-O-L-ascorbyl phosphate (VCP-IS-2Na), which has a C18 alkyl chain attached to the stable ascorbate derivative sodium L-ascorbic acid 2-phosphate (VCP-Na), was evaluated for reduction of cell damage induced by oxidative stress, ultraviolet A (UVA), ultraviolet B (UVB), and H2O2; stimulation of collagen synthesis against UVA irradiation; and inhibition of matrix metalloproteinase-1 (MMP-1) activity induced by UVA in human normal dermal fibroblasts. VCP-IS-2Na pretreatment resulted in significant protection against cell damage induced by UVB, UVA, and H2O2. The amount of type I collagen following UVA irradiation was increased by treatment with VCP-IS-2Na in a concentration-dependent manner. These effects of VCP-IS-2Na were superior to those of L-ascorbic acid (vitamin C, VC) and VCP-Na. On the other hand, VCP-IS-2Na suppressed 65% of the excess MMP-1 irradiated UVA, and VC and VCP-Na slightly suppressed it.
- 社団法人 日本農芸化学会の論文
- 2008-04-23
著者
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Hisama Masayoshi
Central Research Center, Toyo Beauty Co., Ltd.
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Matsuda Sanae
Central Research Center, Toyo Beauty Co., Ltd.
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Iwaki Masahiro
Department of Pharmacy, School of Pharmacy, Kinki University
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Kawase Atsushi
Department Of Pharmacy School Of Pharmacy Kinki University
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Kawase Atsushi
Department Of Pharmacy Kinki University
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Hanada Katsumi
Department Of Dermatology Hirosaki University School Of Medicine
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Iwaki Masahiro
Hbcサイエンス研究所
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Iwaki Masahiro
Department Of Pharmacy School Of Pharmacy Kinki University
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SHIBAYAMA Hiroharu
Department of Dermatology, Jichi Medical University
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Shibayama Hiroharu
Hbc Science Research Center Co. Ltd.
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Hisama Masayoshi
Hbc Science Research Center Co. Ltd.
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Ohtsuki Mamitaro
Department Of Dermatorogy Jichi Medical University
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Ohtsuki Mamitaro
Department Of Dermatology Jichi Medical School
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Hanada Katsumi
Department Of Dermatology Hirosaki University Graduate School Of Medicine
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HISAMA Masayoshi
Central Research Center Research & Development Division, Toyo Beauty Co., Ltd.
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MATSUDA Sanae
Central Research Center Research & Development Division, Toyo Beauty Co., Ltd.
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