Biotransformation of (-)-Menthone by Human Liver Microsomes
スポンサーリンク
概要
- 論文の詳細を見る
The aim of the current study was to investigate the metabolism of (−)-menthone by liver microsomes of humans. (−)-Menthone (1) was metabolized to (+)-neomenthol (2) (3-reduction) and 7-hydroxymenthone (3) by human liver microsomes. The metabolites formed were analyzed on GC and GC–MS. Kinetic analysis showed that Km and Vmax values for the metabolized (−)-menthone to respective (+)-neomenthol and 7-hydroxymenthone by liver microsomes of human sample HG70 were 0.37 mM and 4.91 nmol/min/mg protein and 0.07 mM and 0.71 nmol/min/mg protein.
- 社団法人 日本農芸化学会の論文
- 2006-05-23
著者
-
MIYAZAWA Mitsuo
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
-
Nakanishi Kyousuke
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
-
Miyazawa Mitsuo
Department Of Applied Chemistry Faculty Of Science And Engineering Kinki University
-
Nakanishi Kyousuke
Department Of Applied Chemistry Faculty Of Science And Engineering Kinki University
-
Miyazawa Mitsuo
Department Of Applied Chemistry Faculty Of Scienc Snd Engineering Kinki University
-
Miyazawa Mitsuo
Department Of Aplied Chemistry Faculty Of Science And Engineering Kinki University
関連論文
- Inhibition of Helicobacter pylori Motility by (+)-Syringaresinol from Unripe Japanese Apricot(Medicinal Chemistry)
- Endoscopic pancreatic duct drainage and stenting for acute pancreatitis and pancreatic cyst and abscess
- Metabolism of (+)- and (-)-Menthols by CYP2A6 in Human Liver Microsomes
- Volatile Components of the Straw of Oryza sativa L.
- Comparison of Larvicidal, Adulticidal and Acaricidal Activity of Two Geometrical Butylidenephthalide Isomers(Pharmacognosy)
- Biotransformation of (-)-Menthone by Human Liver Microsomes
- Volatile Flavor Components of ZINGIBERIS RHIZOMA (Zingiber officinale Roscoe)(Organic Chemistry)
- 炭疽病菌による4-propylcyclohexanoneおよび4-isopropylcyclohexanoneの立体選択的還元
- 炭疽病菌による4-tert-butylcyclohexanoneの立体選択的還元
- Essential Oil Constituents of "PAEONIAE RADIX" Peaonia lactiflora Pall. (P. albilora Pall.)
- The Constituents of the Essential Oil from Erigeron philadelphicus
- Convenient Synthesis of Arylmethylenesuccinic Acids via Wittig Reaction
- Character Impact Odorants of Wild Edible Plant-Cacalia hastata L. var. orientalis-Used in Japanese Traditional Food
- Hepatic Metastasis 12 Years after Nephrectomy for Renal Cell Carcinoma
- Inhibitory Compound of Tyrosinase Activity from the Sprout of Polygonum hydropiper L.(Benitade)(Pharmacology)
- Regioselective Oxidation of (+)-α-Longipinene by Aspergillus niger
- Cyclooxygenase-2 inhibitory effects and composition of the volatile oil from the dried roots of Lithospermum erythrorhizon
- Constituents of Essential Oil from the Dried Fruits and Stems of Akebia quinata (THUNB.) DECNE.
- Suppression of the SOS-Inducing Activity of Trp-P-1 and Aflatoxin B_1 by Meso-dihydroguaiaretic Acid from Machilus thunbergii in the Salmonella typhimurium TA1535/pSK1002 umu Test
- Biotransformation of Sinesetin by the Larvae of the Common Cutworm (Spodoptera litura)(Biochemistry/Molecular Biology)
- α-Glucosidase Inhibitor from Bergenia ligulata
- Antimutagenic Compound from Yellow batai (Peltophorum dasyrachis)
- Components of Essential Oil from Woods of Prunus mume Sieb. et Zucc.
- Antimutagenic Activity of Isoflavone from Belamcanda chinensis
- Antimutagenic Activity of Gigantol from Dendrobium nobile
- Antimutagenic Activity of Falcarindiol from Peucedanum praeruptorum
- Antimutagenic Activity of (+)-β-Eudesmol and Paeonol from Dioscorea japonica
- Antimutagenic Activity of Flavonoids from Chrysanthemum morifolium(Biochemistry & Molecular Biology)
- Suppression of Chemical Mutagens-Induced SOS Response by Phenolic Acids from Black Rice Bran Using Salmonella typhimurium TA1535/pSK1002 umu Test
- PB113 SYNTHESIS AND BIOLOGICAL ACTIVITY OF β-D-GLUCOPYRANOSIDE OF THE MONOTERPENE ALCOHOLS
- Characterization of Volatile Aroma Compounds from Red and Black Rice Bran
- Species Differences in the Metabolism of (+)-and (-)-Limonenes and their Metabolites, Carveols and Carvones, by Cytochrome P450 Enzymes in Liver Microsomes of Mice, Rats, Guinea Pigs, Rabbits, Dogs, Monkeys, and Humans
- Volatile Flavor Components of ASTRAGALI RADIX (Astragalus membranaceus Bunge)(Organic Chemistry)
- Suppression of SOS-Inducing Activity of Chemical Mutagens by Yakuchinone A from Alpinia oxyphylla in the Salmonella typhimurium TA1535/pSK1002 umu Test
- The Novel Assay Method for Nicotine Metabolism to Cotinine Using High Performance Liquid Chromatography
- Inhibitory Compounds of α-Glucosidase Activity from Arctium lappa L.
- Identification of the Key Aroma Compounds in Dried Roots of Rubia cordifolia
- Biotransformation of Geraniol by the Larvae of Common Cutworm (Spodoptera litura)
- Use of Solid Phase Microextraction (SPME) for Profiling the Volatile Metabolites Produced by Glomerella cingulata
- Microbial Transformation of (-)-Isolongifolol by Plant Pathogenic Fungus Glomerella cingulata
- Influence of Root Exudates from Cucumis sativus and Daucus carota on Arbuscular Mycorrhizal Colonization
- Contractile and Extensile Effects of Red and White Wine on Rat and Mongolian gerbil Gastrointestinal Smooth Muscle
- Identification of the main aroma compounds in dried seeds of Brassica hirta
- A Useful Synthesis of Alkylidenesuccinic Acids by Wittig Reaction in Aqueous Media
- High-performance liquid chromatographic method for the determination of (-)-verbenone 10-hydroxylation catalyzed by rat liver microsomes
- Biotransformation of (-)-Verbenone by Human Liver Microsomes(Food & Nutrition Science)
- Synthesis and Characterization of New Ascorbic Derivative: Sodium Isostearyl 2-O-L-Ascorbyl Phosphate
- Chemical Composition of Volatile Oil from the Roots of Periploca sepium
- Biotransformation of (-)-Camphor by Salmonella typhimurium OY1002/2A6 Expressing Human CYP2A6 and NADPH-P450 Reductase
- Volatile Flavor Components of SINOMENI CAULIS ET RHIZOMA (Sinomenium acutum Rehder et Wilson)(Organic Chemistry)
- Volatile Flavor Components of PUERARIAE RADIX (Pueraria lobata Ohwi)(Organic Chemistry)
- Volatile Flavor Components of CORNI FRUCTUS (Cornus officinalis Sieb. et Zucc.)(Organic Chemistry)
- Preoperative 18[F]-fluorodeoxyglucose positron emission tomography/computed tomography predicts early recurrence after pancreatic cancer resection
- Biotransformation of Isoflavones by the Larvae of the Common Cutworm (Spodoptera litura)
- Components of the Essential Oil from Matteuccia struthiopteris
- In Vitro Metabolism of (-)-Camphor Using Human Liver Microsomes and CYP2A6(Biochemistry)
- Reduction of Oxazepam to Desmethyldiazepam by Human Intestinal Bacteria
- Components of Essential Oil from Rootstock of Coptis chinensis
- Components of Essential Oil from Rootstock of Coptis chinensis
- Microbial Transformation of Isopimpinellin by Glomerella cingulata
- Metabolism of (+)-Fenchone by CYP2A6 and CYP2B6 in Human Liver Microsomes(Biochemistry)
- Biotransformation of (-)-Dihydromyrcenol and (-)-Dihydromyrcenyl Acetate by the Larvae of Common Cutworm (Spodoptera litura)
- Metabolism of (+)-Terpinen-4-ol by Cytochrome P450 Enzymes in Human Liver Microsomes
- Quantitative Evaluation of (+)-.DELTA.3-Carene Metabolites from Living Larvae of Spodoptera litura by Headspace Solid-phase Microextraction
- Regeneration of extrahepatic bile ducts by tissue engineering with a bioabsorbable polymer
- Analysis of Volatile Organic Compounds Emitted by Plant Growth-Promoting Fungus Phoma sp. GS8-3 for Growth Promotion Effects on Tobacco