Inhibitory Compound of Tyrosinase Activity from the Sprout of Polygonum hydropiper L.(Benitade)(Pharmacology)

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概要

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• A tyrosinase inhibitor was isolated from the sprout of Polygonum hydropiper L. (Benitade) by activity-guided fractionation and identified as (2R,3R)-(+)-taxifolin (1) by spectroscopic means. Compound 1 inhibited 70% of tyrosinase activity at a concentration of 0.50 mM. ID_<50> (50% inhibition dose) value of compound 1 was 0.24 mM. As compared with tyrosinase inhibitor known cosmetic agent such as arbutin and kojic acid, compound I was more inhibited than the former and showed inhibitory effect equal to that of the latter. To study the inhibitory effect of (2R,3R)-(+)-taxifolin derivatives against tyrosinase activity, 3,7,3',4'-taxifolin tetraacetate (2) and 5,7,3',4'-taxifolin teramethyl ether (3) were also assayed together with compound 1.

• 社団法人日本薬学会の論文
• 2007-03-01

著者

• MIYAZAWA Mitsuo

  Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University

• Miyazawa Mitsuo

  Dep. Of Applied Chemistry Fac. Of Sci. And Engineering Kinki Univ.

• TAMURA Naotaka

  Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University

• Miyazawa Mitsuo

  Department Of Applied Chemistry Faculty Of Scienc Snd Engineering Kinki University

• Tamura Naotaka

  Department Of Applied Chemistry Faculty Of Science And Engineering Kinki University

• Miyazawa Mitsuo

  Department Of Aplied Chemistry Faculty Of Science And Engineering Kinki University

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