Metabolism of (+)-Fenchone by CYP2A6 and CYP2B6 in Human Liver Microsomes(Biochemistry)
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概要
- 論文の詳細を見る
The in vitro metabolism of (+)-fenchone was examined in human liver microsomes and recombinant enzymes. Biotransformation of (+)-fenchone was investigated by gas chromatography-mass spectrometry. (+)-Fenchone was found to be oxidized to 6-exo-hydroxyfenchone, 6-endo-hydroxyfenchone and 10-hydroxyfenchone by human liver microsomal P450 enzymes. The formation of metabolite of (+)-fenchone was determined by relative abundance of mass fragments and retention time with GC. CYP2A6 and CYP2B6 in human liver microsomes were major enzymes involved in the hydroxylation of (+)-fenchone, based on the following lines of evidence. First, of eleven recombinant human P450 enzymes tested, CYP2A6 and CYP2B6 catalyzed oxidation of (+)-fenchone. Second, oxidation of (+)-fenchone was inhibited by thioTEPA, (+)-menthofuran anti-CYP2A6 and anti-CYP2B6 antibodies. Finally, there was a good correlation between CYP2A6, CYP2B6 contents and (+)-fenchone hydroxylation activities in liver microsomes of 8 human samples.
- 公益社団法人日本薬学会の論文
- 2006-12-01
著者
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Miyazawa Mitsuo
近畿大学 理工学部応用化学科
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Miyazawa Mitsuo
Department Of Aplied Chemistry Faculty Of Science And Engineering Kinki University
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Gyoubu Kunihiko
Dep. Of Applied Chemistry Fac. Of Sci. And Engineering Kinki Univ.
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Gyoubu Kunihiko
Department Of Applied Chemistry Faculty Of Science And Engineering Kinki University
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