Suppression of the SOS-Inducing Activity of Trp-P-1 and Aflatoxin B_1 by Meso-dihydroguaiaretic Acid from Machilus thunbergii in the Salmonella typhimurium TA1535/pSK1002 umu Test

スポンサーリンク

概要

• 論文の詳細を見る

• The methanol extract from Machilus thunbergii showed a suppressive effect on umu gene expression of the SOS response in Salmonella typhimurium TA1535/pSK1002 against the mutagen, 3-amino-1,4-dimethyl-5H-pyrido [4,3-b] indole (Trp-P-1), which requires liver metabolizing enzymes. The methanol extract from M. thunbergii was successively re-extracted with chloroform, butanol and water. A suppressive compound in the chloroform extract fraction was isolated by SiO_2 column chromatography and identified as meso-dihydroguaiaretic acid by GC-MS, and ^1H-and ^<13>C-NMR spectroscopy. Meso-dihydroguaiaretic acid inhibited of the SOS-inducing activity of Trp-P-1 in the umu test. Gene expression was suppressed by 62% at less than 0.18 μmol/ml, the ID_<50> value being 0.08 μmol/ml. Compound 1 was also assayed with aflatoxin B_1 (AfB_1) and showed a suppressive effect.

• 社団法人日本農芸化学会の論文
• 1998-07-23

著者

• MIYAZAWA Mitsuo

  Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University

• OKUNO Yoshiharu

  Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University

• SHIMAMURA HIDEO

  Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University

• Miyazawa M

  Kinki Univ. Osaka Jpn

• KAMEOKA Hiromu

  Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University

• Okuno Y

  Department Of Applied Chemistry Faculty Of Science And Engineering Kinki University

• Okuno Yoshiharu

  Department Of Applied Chemistry Faculty Of Science And Engineering Kinki University

• OSHIRO Kayo

  Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University

• KASAHARA Hiroyuki

  Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University

• NAKAMURA Seiichi

  Osaka Prefectural Institute of Public Health

• NAKAMURA Sei-ichi

  Osaka Prefectural Institute of Public Healthy

• Miyazawa Mitsuo

  Department Of Applied Chemistry Faculty Of Scienc Snd Engineering Kinki University

• Okuno Y

  Kinki Univ. Osaka Jpn

• Oshiro Kayo

  Department Of Applied Chemistry Faculty Of Science And Engineering Kinki University

• Kameoka Hiromu

  Osaka Prefectural Institute Of Public Healthy

• Kosaka H

  Osaka Prefectural Institute Of Public Health

• Kameoka H

  Department Of Applied Chemistry Faculty Of Science And Engineering Kinki University

• Kameoka Hiromu

  Department Of Applied Chemistry Faculty Of Science And Engineering Kinki University

• Shimamura Hideo

  Department Of Applied Chemistry Faculty Of Science And Engineering Kinki University

• Kasahara Hiroyuki

  Department Of Applied Chemistry Faculty Of Science And Engineering Kinki University

• Miyazawa Mitsuo

  Department Of Aplied Chemistry Faculty Of Science And Engineering Kinki University

関連論文

• Inhibition of Helicobacter pylori Motility by (+)-Syringaresinol from Unripe Japanese Apricot(Medicinal Chemistry)
• Endoscopic pancreatic duct drainage and stenting for acute pancreatitis and pancreatic cyst and abscess
• Mutational Specificity of the Ferrous Ion in a supF Gene of Endonuclease III/VIII Deficient Escherichia coli
• Metabolism of (+)- and (-)-Menthols by CYP2A6 in Human Liver Microsomes
• Volatile Components of the Straw of Oryza sativa L.
• Comparison of Larvicidal, Adulticidal and Acaricidal Activity of Two Geometrical Butylidenephthalide Isomers(Pharmacognosy)
• Biotransformation of (-)-Menthone by Human Liver Microsomes
• Volatile Flavor Components of ZINGIBERIS RHIZOMA (Zingiber officinale Roscoe)(Organic Chemistry)
• 炭疽病菌による4-propylcyclohexanoneおよび4-isopropylcyclohexanoneの立体選択的還元
• 炭疽病菌による4-tert-butylcyclohexanoneの立体選択的還元
• Essential Oil Constituents of "PAEONIAE RADIX" Peaonia lactiflora Pall. (P. albilora Pall.)
• The Constituents of the Essential Oil from Erigeron philadelphicus
• Convenient Synthesis of Arylmethylenesuccinic Acids via Wittig Reaction
• Character Impact Odorants of Wild Edible Plant-Cacalia hastata L. var. orientalis-Used in Japanese Traditional Food
• Hepatic Metastasis 12 Years after Nephrectomy for Renal Cell Carcinoma
• Inhibitory Compound of Tyrosinase Activity from the Sprout of Polygonum hydropiper L.(Benitade)(Pharmacology)
• Regioselective Oxidation of (+)-α-Longipinene by Aspergillus niger
• Cyclooxygenase-2 inhibitory effects and composition of the volatile oil from the dried roots of Lithospermum erythrorhizon
• Constituents of Essential Oil from the Dried Fruits and Stems of Akebia quinata (THUNB.) DECNE.
• Suppression of the SOS-Inducing Activity of Trp-P-1 and Aflatoxin B_1 by Meso-dihydroguaiaretic Acid from Machilus thunbergii in the Salmonella typhimurium TA1535/pSK1002 umu Test
• Biotransformation of Sinesetin by the Larvae of the Common Cutworm (Spodoptera litura)(Biochemistry/Molecular Biology)
• α-Glucosidase Inhibitor from Bergenia ligulata
• Antimutagenic Compound from Yellow batai (Peltophorum dasyrachis)
• Components of Essential Oil from Woods of Prunus mume Sieb. et Zucc.
• Antimutagenic Activity of Isoflavone from Belamcanda chinensis
• Antimutagenic Activity of Gigantol from Dendrobium nobile
• Antimutagenic Activity of Falcarindiol from Peucedanum praeruptorum
• Antimutagenic Activity of (+)-β-Eudesmol and Paeonol from Dioscorea japonica
• Antimutagenic Activity of Flavonoids from Chrysanthemum morifolium(Biochemistry & Molecular Biology)
• Suppression of Chemical Mutagens-Induced SOS Response by Phenolic Acids from Black Rice Bran Using Salmonella typhimurium TA1535/pSK1002 umu Test
• PB113 SYNTHESIS AND BIOLOGICAL ACTIVITY OF β-D-GLUCOPYRANOSIDE OF THE MONOTERPENE ALCOHOLS
• Characterization of Volatile Aroma Compounds from Red and Black Rice Bran
• Species Differences in the Metabolism of (+)-and (-)-Limonenes and their Metabolites, Carveols and Carvones, by Cytochrome P450 Enzymes in Liver Microsomes of Mice, Rats, Guinea Pigs, Rabbits, Dogs, Monkeys, and Humans
• Volatile Flavor Components of ASTRAGALI RADIX (Astragalus membranaceus Bunge)(Organic Chemistry)
• Suppression of SOS-Inducing Activity of Chemical Mutagens by Yakuchinone A from Alpinia oxyphylla in the Salmonella typhimurium TA1535/pSK1002 umu Test
• The Novel Assay Method for Nicotine Metabolism to Cotinine Using High Performance Liquid Chromatography
• 3 Molecular Imaging of Hepatocyte Growth Factor Receptor in Ischemic Rat Heart(Role of Molecular Imaging for Cardiovascular Regeneration Treatments,Topic 2 (TP-2) (I),Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Inhibitory Compounds of α-Glucosidase Activity from Arctium lappa L.
• Identification of the Key Aroma Compounds in Dried Roots of Rubia cordifolia
• Biotransformation of Geraniol by the Larvae of Common Cutworm (Spodoptera litura)
• Use of Solid Phase Microextraction (SPME) for Profiling the Volatile Metabolites Produced by Glomerella cingulata
• Microbial Transformation of (-)-Isolongifolol by Plant Pathogenic Fungus Glomerella cingulata
• Influence of Root Exudates from Cucumis sativus and Daucus carota on Arbuscular Mycorrhizal Colonization
• Contractile and Extensile Effects of Red and White Wine on Rat and Mongolian gerbil Gastrointestinal Smooth Muscle
• Identification of the main aroma compounds in dried seeds of Brassica hirta
• A Useful Synthesis of Alkylidenesuccinic Acids by Wittig Reaction in Aqueous Media
• High-performance liquid chromatographic method for the determination of (-)-verbenone 10-hydroxylation catalyzed by rat liver microsomes
• Biotransformation of (-)-Verbenone by Human Liver Microsomes(Food & Nutrition Science)
• Synthesis and Characterization of New Ascorbic Derivative: Sodium Isostearyl 2-O-L-Ascorbyl Phosphate
• Chemical Composition of Volatile Oil from the Roots of Periploca sepium
• Biotransformation of (-)-Camphor by Salmonella typhimurium OY1002/2A6 Expressing Human CYP2A6 and NADPH-P450 Reductase
• Volatile Flavor Components of SINOMENI CAULIS ET RHIZOMA (Sinomenium acutum Rehder et Wilson)(Organic Chemistry)
• Volatile Flavor Components of PUERARIAE RADIX (Pueraria lobata Ohwi)(Organic Chemistry)
• Volatile Flavor Components of CORNI FRUCTUS (Cornus officinalis Sieb. et Zucc.)(Organic Chemistry)
• Preoperative 18[F]-fluorodeoxyglucose positron emission tomography/computed tomography predicts early recurrence after pancreatic cancer resection
• Biotransformation of Isoflavones by the Larvae of the Common Cutworm (Spodoptera litura)
• Components of the Essential Oil from Matteuccia struthiopteris
• In Vitro Metabolism of (-)-Camphor Using Human Liver Microsomes and CYP2A6(Biochemistry)
• Reduction of Oxazepam to Desmethyldiazepam by Human Intestinal Bacteria
• Components of Essential Oil from Rootstock of Coptis chinensis
• A Prunus mume Extract Stimulated the Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells
• Components of Essential Oil from Rootstock of Coptis chinensis
• Microbial Transformation of Isopimpinellin by Glomerella cingulata
• A Prunus mume Extract Stimulated the Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells
• Metabolism of (+)-Fenchone by CYP2A6 and CYP2B6 in Human Liver Microsomes(Biochemistry)
• Biotransformation of (-)-Dihydromyrcenol and (-)-Dihydromyrcenyl Acetate by the Larvae of Common Cutworm (Spodoptera litura)
• Metabolism of (+)-Terpinen-4-ol by Cytochrome P450 Enzymes in Human Liver Microsomes
• Quantitative Evaluation of (+)-.DELTA.3-Carene Metabolites from Living Larvae of Spodoptera litura by Headspace Solid-phase Microextraction
• Regeneration of extrahepatic bile ducts by tissue engineering with a bioabsorbable polymer
• Analysis of Volatile Organic Compounds Emitted by Plant Growth-Promoting Fungus Phoma sp. GS8-3 for Growth Promotion Effects on Tobacco

もっと見る 閉じる

スポンサーリンク