Measurements of Cardiac Ion Channel Subunits in the Chronic Atrioventricular Block Dog
スポンサーリンク
概要
- 論文の詳細を見る
The chronic atrioventricular block (CAVB) dog has been widely used as an in vivo proarrhythmia model. mRNA levels of K+ and Ca2+ channels in the isolated ventricular tissues from normal and CAVB dogs were assayed using a real-time PCR. The mRNA levels of KvLQT1 and MiRP1 were significantly less in the CAVB heart compared with those in the intact heart, whereas no significant difference was detected in the mRNA levels of other K+- or Ca2+-channel subunits. Adaptation against chronic bradycardia–related pathophysiology may have decreased the mRNA levels of cardiac K+ channels, which may partly explain the arrhythmogenic property of this model.
著者
-
Sugiyama Atsushi
Department of Pharmacology, School of Medicine, Toho University, Japan
-
Nakamura Yuji
Department of Pharmacology, School of Medicine, Toho University, Japan
-
Takahara Akira
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
-
Takahara Akira
Department Of Internal Medicine National Kawatana Hospital
-
Sugiyama Atsushi
Department Of Pharmacology Yamanashi Medical University
-
Nakamura Yuji
Department Of Materials Engineering Graduate School Of Engineering The University Of Tokyo:crest Jap
-
Wagatsuma Hirotaka
Research Center, Ajinomoto Pharmaceuticals, Japan
-
Aritomi Shizuka
Research Center, Ajinomoto Pharmaceuticals, Japan
-
Konda Tomoyuki
Research Center, Ajinomoto Pharmaceuticals, Japan
-
Akie Yasuki
Sugi Institute of Biological Science, Japan
-
Nakamura Yuji
Department Of Anesthesiology Shimane Medical University
関連論文
- Blocking effect of NIP-142 on the KCNQ1/KCNE1 channel current expressed in HEK293 cells
- Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research:In Vivo Proarrhythmia Models of Drug-Induced Long QT Syndrome: Development of Chronic Atrioventricular Block Model of Microminipig
- Developmental Changes in Action Potential Prolongation by K+-Channel Blockers in Chick Myocardium
- Electrophysiological and Pharmacological Characteristics of Triggered Activity Elicited in Guinea-Pig Pulmonary Vein Myocardium
- Blocking Effect of NIP-142 on the KCNQ1/KCNE1 Channel Current Expressed in HEK293 Cells
- Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research:Preface
- In Vivo Electropharmacological Effects of Amiodarone and Candesartan on Atria of Chronic Atrioventricular Block Dogs
- Comparison of Four Rate-Correction Algorisms for the Ventricular Repolarization Period in Assessing Net Effects of I_ Blockers in Dogs
- New Aspects for the Treatment of Cardiac Diseases Based on the Diversity of Functional Controls on Cardiac Muscles : Diversity in the Excitation-Contraction Mechanisms of the Heart
- New Aspects for the Treatment of Cardiac Diseases Based on the Diversity of Functional Controls on Cardiac Muscles: Diversity in the Excitation–Contraction Mechanisms of the Heart
- Species Difference in the Contribution of T-Type Calcium Current to Cardiac Pacemaking as Revealed by R(-)-Efonidipine
- OJ-071 Chronic Atrioventricular Block Abbreviated the Action Potential Duration of Canine Pulmonary Vein Myocardium(Arrythmia, basic(02)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Analysis of Arrhythmogenic Profile in a Canine Model of Chronic Atrioventricular Block by Comparing In Vitro Effects of the Class III Antiarrhythmic Drug Nifekalant on the Ventricular Action Potential Indices Between Normal Heart and Atrioventricular Bloc
- Effect of NIP-142 on Potassium Channel α-Subunits Kv1.5, Kv4.2 and Kv4.3, and Mouse Atrial Repolarization
- Crystal Structure Analysis of a Hexatungstate by a High-Energy X-ray Diffraction Experiment Using an Imaging Plate Weissenberg Camera at the BL04B2 Beamline of SPring-8^1
- In Vivo Antiarrhythmic Profile of AP-792 Assessed in Different Canine Arrhythmia Models
- Involvement of the Na^+/Ca^ Exchanger in the Automaticity of Guinea-Pig Pulmonary Vein Myocardium as Revealed by SEA0400
- Comparison of the Electropharmacological Effects of Verapamil and Propranolol in the Halothane-Anesthetized In Vivo Canine Model Under Monophasic Action Potential Monitoring
- Constitutional Rho-Kinase Regulates the Electrophysiological and Mechanical Function of the Heart Besides the Coronary Vascular Tone
- Cardiac Effects of a Selective Rho-Associated Kinase Inhibitor, Y-27632, Assessed in Canine Isolated, Blood-Perfused Heart Preparations
- Effects of Sphingosine 1-Phosphate, a Naturally Occurring Biologically Active Lysophospholipid, on the Rat Cardiovascular System
- Block of Na exchangers on ischemia induced arrhythmias
- Effects of Acute Intravenous Administration of Pentamidine, a Typical hERG-Trafficking Inhibitor, on the Cardiac Repolarization Process of Halothane-Anesthetized Dogs
- Bone Metabolism after Human Parturition and the Effect of Lactation: Longitudinal Analysis of Serum Bone-Related Proteins and Bone Mineral Content of the Lumbar Spine
- Suppression of SOS-Inducing Activity of Chemical Mutagens by Yakuchinone A from Alpinia oxyphylla in the Salmonella typhimurium TA1535/pSK1002 umu Test
- Radiotherapy under Informed Consent Report ofa Long - Term Survivor of Advanced Esophageal Cancer
- 0453 INHIBITION OF Na^+/H^+ EXCHANGE SUPPRESSES BOTH REBOUND RECOVERY OF MYOCARDIAL CREATINE PHOSPHATE (Cr-P) AND LETHAL ARRHYTHMIAS DURING REPERFUSION AFTER A BRIEF ISCHEMIA
- Simultaneous Assessment of Pharmacokinetics of Pilsicainide Transdermal Patch and Its Electropharmacological Effects on Atria of Chronic Atrioventricular Block Dogs
- Comparison of Electropharmacological Effects of Bepridil and Sotalol in Halothane-Anesthetized Dogs
- OJ-006 Comparison of Electropharmacological Effects of Sotalol and Bepridil Assessed in the in Vivo Canine Heart(Cardiovascular pharmacology, basic/clinical-2 (H) OJ1,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japan
- Purification and Properties of an Aminopeptidase from a Protamine-degrading Marine Bacterium
- Microbial Transformation of Carbazole to Indole-3-acetic Acid by Flavobacterium sp. OCM-1
- Clinical utility of quantitative RT-PCR targeted to α1,4-N-acetylglucosaminyltransferase mRNA for detection of pancreatic cancer
- Suppressive effect of rice extract on Helicobacter pylori infection in a Mongolian gerbil model
- Eradication of Helicobacter pylori decreases mucosal alterations linked to gastric carcinogenesis in Mongolian gerbils
- Dissolution Process of Copper Sulfate into Water in a Heterogeneous Vertical Magnetic Field
- P400 CAN THE MAP TECHNIQUE BE APPLIED TO DETECT DELAYED AFTERDEPOLARIZATION ? : ELECTROPHYSIOLOGICAL AND PHARMACOLOGICAL EVIDENCE
- 0901 EFFECT OF A CLASS III ANTIARRHYTHMIC DRUG ON REFRATORY PERIOD. : DEMONSTRATION OF REVERSE USE DEPENDENCY ASSESSED BY MONOPHASIC ACTION POTENTIALS.
- -P159- Effects of Sodium and Calcium Channel Blockers on Monophasic Action Potential(MAP)Recordings Assessed by the Canine Isolated, Blood-Perfused Ventricular Tissue Preparation(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATIO
- -P157- Electrophysiological and Pharmacological Characteristics of Digitalis-induced Triggered Activity in the Canine Isolated, Blood-perfused Ventricular Muscle Preparation.(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SO
- High Temperature Estimation of Phase Coherent Length of Hot Electron Using GaInAs/InP Triple-Barrier Resonant Tunneling Diodes Grown by OMVPE
- Comparison of the sensitivity of various in vivo animal models for detecting the drug-induced QT interval prolongation(General toxicology, Test methods (1), Proceedings of the 32nd Annual Meeting)
- A Red Wine Vinegar Beverage can Inhibit the Renin-Angiotensin System : Experimental Evidence in Vivo(Pharmacology)
- The Endothelium-Dependent Vasodilator Action of a New Beverage Made of Red Wine Vinegar and Grape Juice(Pharmacology)
- Dangerous QT Prolongation Can be Assayed with Two Types of In Vivo Models ; Halothane-Anesthetized Dog and Chronic Atrioventricular Block Dog(Cardiovascular Pharmacology, Basic/Clinical 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation
- The Antipsychotic and Antiemetic Drug Prochlorperazine Delays the Ventricular Repolarization of the In Situ Canine Heart
- Electropharmacological Effects of a Spironolactone Derivative, Potassium Canrenoate, Assessed in the Halothane-Anesthetized Canine Model
- Cardiovascular Effects of an L/N-type Ca^ Channel Blocker Cilnidipine Assessed in the Chronic Atrioventricular Conduction Block Dogs
- PE-353 Mexiletine Decreased the Ventricular Electrical Vulnerability in the Canine Model of Sparfloxacin-Induced Long QT Syndrome(Cardiovascular Pharmacology, Basic/Clinical 3 (H) : PE60)(Poster Session (English))
- OE-275 A Spironolactone Derivative, Potassium Canrenoate, Prolongs the QT Interval but Shortens the Electrically Vulnerable Period of In Vivo Canine Hearts(Cardiovascular Pharmacology, Basic/Clinical 1 (H) : OE34)(Oral Presentation (English))
- The QT-Prolonging Effects of a Histamine H1 Receptor Antagonist Terfenadine Assessed in the In Vivo Canine Heart Model: Comparison of the Rate-Correcting Methods for the Ventricular Repolarization Periods
- Relationship Between Phosphodiesterase Inhibition Induced by Several Kampo Medicines and Smooth Muscle Relaxation of Gastrointestinal Tract Tissues of Rats
- N- Plus L-Type Ca^ Channel Blocker Cilnidipine Decreased the Proarrhythmic Potential of the Canine Sudden Cardiac Death Model
- Effects of Clinically Available Blended Herbal Medicines (Kampo Extracts) on the Phosphodiesterase Activity in Rat Hearts
- Cardiovascular and Adenylate Cyclase Stimulating Effects of Colforsin Daropate, a Water-Soluble Forskolin Derivative, Compared With Those of Isoproterenol, Dopamine and Dobutamine
- Effects of Disopyramide and Mexiletine on the Terminal Repolarization Process of the In Situ Heart Assessed Using the Halothane-Anesthetized In Vivo Canine Model
- Comparison of the In Vivo Electrophysiological and Proarrhythmic Effects of Amiodarone With Those of a Selective Class III Drug, Sematilide, Using a Canine Chronic Atrioventricular Block Model
- Effects of a Novel Vesamicol Receptor Ligand, m-(Iodobenzyl)trozamicol, on the Canine Isolated, Blood-Perfused Atrioventricular Node Preparation
- -0933- Measurement of Adenylyl Cyclase Activity in the Contractile and Conductive Elements of the Canine Heart : Comparison of the Regional Adenylyl Cyclase Activity after the Treatment by Purinergic or Cholinergic Agonists.(PROCEEDINGS OF THE 59th ANNUAL
- Measurements of Cardiac Ion Channel Subunits in the Chronic Atrioventricular Block Dog
- Induction of Labor at 41 Weeks of Gestation in Uncomplicated Prolonged Pregnancy
- Effect of High Glucose Concentration on Mitochondrial Metabolism in Neuronal Cells
- Cardiovascular Effects of Orally Administered HNS-32, an Originally Synthesized Azulene-1-carboxamidine Derivative, Assessed in the In Vivo Rat Model
- Pharmacological and Electrophysiological Characterization of Junctional Rhythm During Radiofrequency Catheter Ablation of the Atrioventricular Node : Possible Involvement of Neurotransmitters From Autonomic Nervous System
- Electrophysiological, Anatomical and Histological Remodeling of the Heart to AV Block Enhances Susceptibility to Arrhythmogenic Effects of QT-Prolonging Drugs
- Molecular Mechanisms of Cardiostimulatory Effects of Sildenafil
- Effects of Sildenafil (Viagra TM) on the Cyclic AMP Hydrolyzing Phosphodiesterase Activity in the Canine Heart Assessed Using a Modified Enzymatic Fluorometric Assay Technique
- Effects of ONO : 2235, an Aldose Reductase Inhibitor, on Muscarinic Receptors and Contractile Response of the Urinary Bladder in Rats with Streptozotocin : Induced Diabetes
- DECREASE OF PLASMA SULFUR AMINO ACIDS IN ESSENTIAL HYPERTENSION
- Enantioselective Synthesis of a (+)-(2R, 3R)-1,4-Benzodioxane-7-carbaldehyde Derivative, a Key Intermediate in the Total Synthesis of Haedoxan Analogs
- Giant Negative Thermal Expansion in Mn-Rich bcc Cr-Mn Alloys
- Clinical Study of Delapril Hydrochloride in Patients with Acute Myocardial Infarction: Effects of Early ACE Inhibition foflowing Effective Thrombofytic Coronary Recanalizati
- Enzymatic Fluorometric Assay for Adenylyl Cyclase Activity Comparison with Radioimmunoassay and Original [alpha-32P] ATP Salomon Method
- Effects of Mexiletine on the Canine Cardiovascular System Complicating Cisapride Overdose: Potential Utility of Mexiletine for the Treatment of Drug-Induced Long QT Syndrome
- Effect of Magnesium Sulfate on the Haloperidol-Induced QT Prolongation Assessed in the Canine In Vivo Model Under the Monitoring of Monophasic Action Potential
- Effects of a Class III Antiarrhythmic Drug, Dofetilide, on the In Situ Canine Heart Assessed by the Simultaneous Monitoring of Hemodynamic and Electrophysiological Parameters
- Spontaneous respiration should be avoided in frequency domain analysis of heart rate variability
- Epidural anesthesia for cesarean section in triplet pregnant women with toxemia and complication of ritodrine therapy: five case reports
- SUCCINIC ACID PRODUCTION BY THE SAKE YEAST AND ECOLOGICAL CONSIDERATIONS ON THE YEAST ACTION
- Cardiac Effects of Clinically Available Kampo Medicine Assessed With Canine Isolated, Blood-Perfused Heart Preparations
- Famotidine neither affects action potential parameters nor inhibits human ether-a-go-go-related gene (hERG) K^+ current
- Characterization of the Halothane-Anesthetized Guinea-Pig Heart as a Model to Detect the K^+ Channel Blocker-Induced QT-Interval Prolongation(Pharmacology)
- PJ-719 Beat-to-beat Variability of Ventricular Repolarization Period Can Predict Onset of Acquired Long QT Syndrome(Arrhythmia, basic-6 (A) PJ121,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-345 Long-term Blockade of N-type Ca^ Channels Reversed the Ventricular Electrical Remodeling in the Canine Model of Long QT Syndrome(Cardiovascular pharmacology, basic/clinical-4 (H) PJ58,Poster Session (Japanese),The 70th Anniversary Annual Scient
- Halothane Sensitizes the Guinea-Pig Heart to Pharmacological I_ Blockade : Comparison With Urethane Anesthesia
- A Simple In Vivo Atrial Fibrillation Model of Rat Induced by Transesophageal Atrial Burst Pacing
- Utility of Short-Term Variability of Repolarization as a Marker for Monitoring a Safe Exercise Training Program in Patients With Cardiac Diseases
- Cardiac Effects of Salvia Miltiorrhiza/Dalbergia Odorifera Mixture, an Intravenously Applicable Chinese Medicine Widely Used for Patients With Ischemic Heart Disease in China
- Effect of New Type β-blocker, Tilisolol Hydrochloride,on the Cardiovascular System in Healthy Young Volunteers
- P8-24 Time-course of cardiovascular adaptation in the complete atrioventricular conduction block model(CIRCULATORY SYSTEM-2/ACTIVE OXYGEN)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- H2 Receptor-Mediated Positive Inotropic Effect of Histamine in Neonatal Guinea-Pig Left Atria
- Cardiovascular Effects of L-158,809, a New Angiotensin Type 1 Receptor Antagonist, Assessed Using the Halothane-Anesthetized In Vivo Canine Model
- Acute Electropharmacological Effects of Intravenously Administered Amiodarone Assessed in the In Vivo Canine Model
- Pharmacological Evaluation of a New Laser Blood Flowmeter for Measuring Coronary Blood Flow, Assessed in the Canine Isolated, Blood-Perfused Ventricular Tissue Preparation in Comparison With an Electromagnetic Flowmeter
- DROMOTROPIC AND CHRONOTROPIC EFFECTS OF CLASS I ANTIARRHYTHMIC AGENTS IN THE CANINE ISOLATED, BLOOD-PERFUSED PAPILLARY MUSCLE PREPARATIONS : Cardiovascular Drugs : 53 Annual Scientific Meeting, Japanese Circulation Society
- Measurements of Cardiac Ion Channel Subunits in the Chronic Atrioventricular Block Dog
- Developmental Changes in Action Potential Prolongation by K^+-Channel Blockers in Chick Myocardium
- Electrophysiological and Pharmacological Characteristics of Triggered Activity Elicited in Guinea-Pig Pulmonary Vein Myocardium
- Electrophysiological Effects of the Class Ic Antiarrhythmic Drug Pilsicainide on the Guinea-Pig Pulmonary Vein Myocardium
- Effects of the Antitussive Drug Cloperastine on Ventricular Repolarization in Halothane-Anesthetized Guinea Pigs