Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research:Preface

スポンサーリンク

概要

• 論文の詳細を見る

• Fuji Micra Inc. has recently achieved success in a challenging and prospective project that produces the smallest pig in the world, the “Microminipig”, at a breeding farm at the foothills of Mt. Fuji in Japan. Microminipigs weigh approximately 7.0 kg at 6 months of age when they are mature. Microminipigs have been provided to several research organizations in Japan as a non-rodent experimental animal optimized for life science research.

著者

• KANEKO Naoki

  Fuji Micra Inc.

• IZUMI Yasukatsu

  Department of Pharmacology, Osaka City University Medical School

• Sugiyama Atsushi

  Department of Pharmacology, School of Medicine, Toho University, Japan

• Itoh Katzuhiko

  Fuji Micra Inc., Japan

• Sugiyama Atsushi

  Department Of Pharmacology Yamanashi Medical University

• Sugiyama A

  Department Of Pharmacology Yamanashi Medical University

• Izumi Yasukatsu

  Department Of Pharmacology Osaka City University Graduate School Of Medicine

• Sugiyama Atsushi

  Department Of Chemistry College Of Science Rikkyo University

関連論文

• 肝P450等の薬物代謝酵素活性を指標とした日本発新規ヒト型モデル動物"マイクロミニブタ"の非臨床試験における高い将来性
• Collaborative work on evaluation of ovarian toxicity : 16) Effects of 2 or 4 weeks repeated dose studies and fertility study of Chlorpromazine hydrochloride in rats
• Effects of Liposome Clodronate on Renal Leukocyte Populations and Renal Fibrosis in Murine Obstructive Nephropathy
• Pravastatin accelerates ischemia-induced angiogenesis through AMP-activated protein kinase
• Effects of metoprolol on epinephrine-induced takotsubo-like left ventricular dysfunction in non-human primates
• PJ-186 Heat Shock Cognate Protein 70 is Essential for Akt Signaling in Endothelial Functions(PJ032,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulat
• Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research:Novel Atherosclerosis Model Induced by High Fat and Cholesterol Diet
• Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research:In Vivo Proarrhythmia Models of Drug-Induced Long QT Syndrome: Development of Chronic Atrioventricular Block Model of Microminipig
• Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research:Preface
• In Vivo Electropharmacological Effects of Amiodarone and Candesartan on Atria of Chronic Atrioventricular Block Dogs
• Comparison of Four Rate-Correction Algorisms for the Ventricular Repolarization Period in Assessing Net Effects of I_ Blockers in Dogs
• OJ-071 Chronic Atrioventricular Block Abbreviated the Action Potential Duration of Canine Pulmonary Vein Myocardium(Arrythmia, basic(02)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Analysis of Arrhythmogenic Profile in a Canine Model of Chronic Atrioventricular Block by Comparing In Vitro Effects of the Class III Antiarrhythmic Drug Nifekalant on the Ventricular Action Potential Indices Between Normal Heart and Atrioventricular Bloc
• AVAILABILITY OF SPERM EXAMINATION FOR MALE REPRODUCTIVE TOXICITIES IN RATS TREATED WITH BORIC ACID
• The Long-Acting Ca^-Channel Blocker Azelnidipine Prevents Left Ventricular Remodeling After Myocardial Infarction
• Angiotensin Blockade Inhibits Osteopontin Expression in Non-infarcted Myocardium After Myocardial Infarction
• Angiotensin Blockades Inhibit Osteopontin Expression in Non-infarcted Myocardium after Myocardial Infarction(Old Myocardial Infarction/Remodeling 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Effects of Eplerenone on Transcriptional Factors and mRNA Expression Related to Cardiac Remodeling after Myocardial Infarction(Renin-angiotensin-aldosterone System (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• In Vivo Antiarrhythmic Profile of AP-792 Assessed in Different Canine Arrhythmia Models
• Comparison of the Electropharmacological Effects of Verapamil and Propranolol in the Halothane-Anesthetized In Vivo Canine Model Under Monophasic Action Potential Monitoring
• Effects of Cellular Cardiomyoplasty on Ventricular Remodeling Assessed by Doppler Echocardiography and Topographic Immunohistochemistry
• A novel gene therapy of vascular remodeling utilizing dominant negative mutants of mitogen-activated protein (MAP) kinase family
• Gene Expression Profile in Experimental Mesangial Proliferative Glomerulonephritis
• Effects of Aldosterone Receptor Antagonist and Angiotensin II Type I Receptor Blocker on Cardiac Transcriptional Factors and mRNA Expression in Rats With Myocardial Infarction
• PJ-556 Effects of aldosterone antagonist and angiotensin II type I receptor blocker on cardiac AP-1 and NF-κB in myocardial infarcted rat(Old myocardial Infarction/Remodeling 2 (IHD) : PJ93)(Poster Session (Japanese))
• PJ-044 Cell Transplantation for the Treatment of Acute Myocardial Infarction Using Vascular Endothelial Growth Factor-Expressing Mesenchymal Stem Cells(Acute Myocardial Infarction, Basic 2 (IHD) : PJ8)(Poster Session (Japanese))
• Granulocyte-Colony Stimulating Factor Augments Neovascularization Induced by Bone Marrow Transplantation in Rat Hind Limb Ischemia
• Constitutional Rho-Kinase Regulates the Electrophysiological and Mechanical Function of the Heart Besides the Coronary Vascular Tone
• Cardiac Effects of a Selective Rho-Associated Kinase Inhibitor, Y-27632, Assessed in Canine Isolated, Blood-Perfused Heart Preparations
• Effects of Sphingosine 1-Phosphate, a Naturally Occurring Biologically Active Lysophospholipid, on the Rat Cardiovascular System
• Angiotensin Receptor Blocker Improves Diastolic Heart Failure Even on the End Stage by the Inhibition of Oxidative Stress and Inflammation (Cardiac Hypertrophy, Basic (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Aldosterone Induces Cardiac Injury More Potently than Angiotensin II, through Superoxide-independent Oxidative Stress(Renin-angiotensin-aldosterone System (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-305 Activation of Apoptosis Signal-Regulating Kinase 1 Plays a Critical Role in Vascular Neointimal Hyperplasia(Restenosis after Angioplasty, Basic/Clinical 2 (IHD) : OJ36)(Oral Presentation (Japanese))
• FRS-020 Apoptosis Signal-Regulating Kinase 1 plays a critical role in Angiotensin II-Induced Cardiac Hypertrophy and Remodeling(Cardiac Hypertrophy (M) : FRS3)(Featured Research Session (English))
• Gene Transfer of Dominant-Negative Apoptosis Signal-Regulating Kinase 1 Prevents Neointimal Formation in Balloon-Injured Artery
• Role of c-Jun NH_2 Terminal Kinase in G-Protein-Coupled Receptor Agonist-Induced Cardiac Plasminogen Activator Inhibitor-1 Gene Expression
• Involvement of c-Jun NH_2 Terminal Kinase and p38MAPK in Rapamycin-Mediated Inhibition of Neolntimal Formation in Balloon-Injured Rat Carotid Artery
• Gene Transfer of Dominant-Negative Apoptosis Signal-Regulating Kinase 1 (ASK1) Prevents Angiotensin II-Induced Cardiac Hypertrophy
• Dominant negative mutant of c-Jun inhibits cardiomyocyte hypertrophy through inhibition of AP-1 transcriptional activity
• Angiotensin II-induced cardiac MCP-1 gene expression is partially mediated by p38MAPK activation
• Endothelial progenitor cells prevent neointimal formation in balloon-injured rat carotid artery
• Block of Na exchangers on ischemia induced arrhythmias
• Effects of Acute Intravenous Administration of Pentamidine, a Typical hERG-Trafficking Inhibitor, on the Cardiac Repolarization Process of Halothane-Anesthetized Dogs
• Beneficial Effect of Candesartan on Rat Diastolic Heart Failure
• Excess Aldosterone under Normal Salt Diet Induces Cardiac Hypertrophy and Infiltration via Oxidative Stress
• Additive Beneficial Effects of the Combination of a Calcium Channel Blocker and an Angiotensin Blocker on a Hypertensive Rat-Heart Failure Model
• Renal Fibrosis in Murine Obstructive Nephropathy Is Attenuated by Depletion of Monocyte Lineage, Not Dendritic Cells
• Pharmacogenomics of Cardiovascular Pharmacology : Molecular Network Analysis in Pleiotropic Effects of Statin : an Experimental Elucidation of the Pharmacologic Action From Protein-Protein Interaction Analysis
• 0453 INHIBITION OF Na^+/H^+ EXCHANGE SUPPRESSES BOTH REBOUND RECOVERY OF MYOCARDIAL CREATINE PHOSPHATE (Cr-P) AND LETHAL ARRHYTHMIAS DURING REPERFUSION AFTER A BRIEF ISCHEMIA
• Simultaneous Assessment of Pharmacokinetics of Pilsicainide Transdermal Patch and Its Electropharmacological Effects on Atria of Chronic Atrioventricular Block Dogs
• Comparison of Electropharmacological Effects of Bepridil and Sotalol in Halothane-Anesthetized Dogs
• OJ-006 Comparison of Electropharmacological Effects of Sotalol and Bepridil Assessed in the in Vivo Canine Heart(Cardiovascular pharmacology, basic/clinical-2 (H) OJ1,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japan
• Purification and Properties of an Aminopeptidase from a Protamine-degrading Marine Bacterium
• Microbial Transformation of Carbazole to Indole-3-acetic Acid by Flavobacterium sp. OCM-1
• Clinical utility of quantitative RT-PCR targeted to α1,4-N-acetylglucosaminyltransferase mRNA for detection of pancreatic cancer
• Suppressive effect of rice extract on Helicobacter pylori infection in a Mongolian gerbil model
• Eradication of Helicobacter pylori decreases mucosal alterations linked to gastric carcinogenesis in Mongolian gerbils
• Dissolution Process of Copper Sulfate into Water in a Heterogeneous Vertical Magnetic Field
• P400 CAN THE MAP TECHNIQUE BE APPLIED TO DETECT DELAYED AFTERDEPOLARIZATION ? : ELECTROPHYSIOLOGICAL AND PHARMACOLOGICAL EVIDENCE
• 0901 EFFECT OF A CLASS III ANTIARRHYTHMIC DRUG ON REFRATORY PERIOD. : DEMONSTRATION OF REVERSE USE DEPENDENCY ASSESSED BY MONOPHASIC ACTION POTENTIALS.
• -P159- Effects of Sodium and Calcium Channel Blockers on Monophasic Action Potential(MAP)Recordings Assessed by the Canine Isolated, Blood-Perfused Ventricular Tissue Preparation(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATIO
• -P157- Electrophysiological and Pharmacological Characteristics of Digitalis-induced Triggered Activity in the Canine Isolated, Blood-perfused Ventricular Muscle Preparation.(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SO
• Comparison of the sensitivity of various in vivo animal models for detecting the drug-induced QT interval prolongation(General toxicology, Test methods (1), Proceedings of the 32nd Annual Meeting)
• A Red Wine Vinegar Beverage can Inhibit the Renin-Angiotensin System : Experimental Evidence in Vivo(Pharmacology)
• The Endothelium-Dependent Vasodilator Action of a New Beverage Made of Red Wine Vinegar and Grape Juice(Pharmacology)
• Dangerous QT Prolongation Can be Assayed with Two Types of In Vivo Models ; Halothane-Anesthetized Dog and Chronic Atrioventricular Block Dog(Cardiovascular Pharmacology, Basic/Clinical 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation
• The Antipsychotic and Antiemetic Drug Prochlorperazine Delays the Ventricular Repolarization of the In Situ Canine Heart
• Electropharmacological Effects of a Spironolactone Derivative, Potassium Canrenoate, Assessed in the Halothane-Anesthetized Canine Model
• Cardiovascular Effects of an L/N-type Ca^ Channel Blocker Cilnidipine Assessed in the Chronic Atrioventricular Conduction Block Dogs
• PE-353 Mexiletine Decreased the Ventricular Electrical Vulnerability in the Canine Model of Sparfloxacin-Induced Long QT Syndrome(Cardiovascular Pharmacology, Basic/Clinical 3 (H) : PE60)(Poster Session (English))
• OE-275 A Spironolactone Derivative, Potassium Canrenoate, Prolongs the QT Interval but Shortens the Electrically Vulnerable Period of In Vivo Canine Hearts(Cardiovascular Pharmacology, Basic/Clinical 1 (H) : OE34)(Oral Presentation (English))
• The QT-Prolonging Effects of a Histamine H1 Receptor Antagonist Terfenadine Assessed in the In Vivo Canine Heart Model: Comparison of the Rate-Correcting Methods for the Ventricular Repolarization Periods
• Relationship Between Phosphodiesterase Inhibition Induced by Several Kampo Medicines and Smooth Muscle Relaxation of Gastrointestinal Tract Tissues of Rats
• N- Plus L-Type Ca^ Channel Blocker Cilnidipine Decreased the Proarrhythmic Potential of the Canine Sudden Cardiac Death Model
• Effects of Clinically Available Blended Herbal Medicines (Kampo Extracts) on the Phosphodiesterase Activity in Rat Hearts
• Cardiovascular and Adenylate Cyclase Stimulating Effects of Colforsin Daropate, a Water-Soluble Forskolin Derivative, Compared With Those of Isoproterenol, Dopamine and Dobutamine
• Effects of Disopyramide and Mexiletine on the Terminal Repolarization Process of the In Situ Heart Assessed Using the Halothane-Anesthetized In Vivo Canine Model
• Comparison of the In Vivo Electrophysiological and Proarrhythmic Effects of Amiodarone With Those of a Selective Class III Drug, Sematilide, Using a Canine Chronic Atrioventricular Block Model
• Effects of a Novel Vesamicol Receptor Ligand, m-(Iodobenzyl)trozamicol, on the Canine Isolated, Blood-Perfused Atrioventricular Node Preparation
• -0933- Measurement of Adenylyl Cyclase Activity in the Contractile and Conductive Elements of the Canine Heart : Comparison of the Regional Adenylyl Cyclase Activity after the Treatment by Purinergic or Cholinergic Agonists.(PROCEEDINGS OF THE 59th ANNUAL
• Measurements of Cardiac Ion Channel Subunits in the Chronic Atrioventricular Block Dog
• Effect of High Glucose Concentration on Mitochondrial Metabolism in Neuronal Cells
• Cardiovascular Effects of Orally Administered HNS-32, an Originally Synthesized Azulene-1-carboxamidine Derivative, Assessed in the In Vivo Rat Model
• Pravastatin Induces Rat Aortic Endothelial Cell Proliferation and Migration via Activation of PI3K/Akt/mTOR/p70 S6 Kinase Signaling
• The Important Role of Apoptosis Signal-regulating Kinase 1 in Ischemia-induced Angiogenesis(Angiogenesis 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Pharmacological and Electrophysiological Characterization of Junctional Rhythm During Radiofrequency Catheter Ablation of the Atrioventricular Node : Possible Involvement of Neurotransmitters From Autonomic Nervous System
• Electrophysiological, Anatomical and Histological Remodeling of the Heart to AV Block Enhances Susceptibility to Arrhythmogenic Effects of QT-Prolonging Drugs
• Molecular Mechanisms of Cardiostimulatory Effects of Sildenafil
• Effects of Sildenafil (Viagra TM) on the Cyclic AMP Hydrolyzing Phosphodiesterase Activity in the Canine Heart Assessed Using a Modified Enzymatic Fluorometric Assay Technique
• Effects of ONO : 2235, an Aldose Reductase Inhibitor, on Muscarinic Receptors and Contractile Response of the Urinary Bladder in Rats with Streptozotocin : Induced Diabetes
• PE-216 Loss of menage-a-trois 1 in cardiomyocytes causes mitochondrial dysfunction(Metabolism/Biochemistry/Energetics(02)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Clinical Study of Delapril Hydrochloride in Patients with Acute Myocardial Infarction: Effects of Early ACE Inhibition foflowing Effective Thrombofytic Coronary Recanalizati
• Enzymatic Fluorometric Assay for Adenylyl Cyclase Activity Comparison with Radioimmunoassay and Original [alpha-32P] ATP Salomon Method
• Restraint-induced maternal stress and alteration of ossification in mouse fetuses
• Renal Fibrosis in Murine Obstructive Nephropathy Is Attenuated by Depletion of Monocyte Lineage, Not Dendritic Cells
• Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research : In Vivo Proarrhythmia Models of Drug-Induced Long QT Syndrome : Development of Chronic Atrioventricular Block Model of Microminipig
• Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research : Preface
• Novel Device That Produces Carbon Dioxide Mist for Myocardial Infarction Treatment in Rats
• Red Ginseng Inhibits Scratching Behavior Associated With Atopic Dermatitis in Experimental Animal Models
• The antifibrotic agent pirfenidone inhibits angiotensin II-induced cardiac hypertrophy in mice

もっと見る 閉じる

スポンサーリンク