Simultaneous Assessment of Pharmacokinetics of Pilsicainide Transdermal Patch and Its Electropharmacological Effects on Atria of Chronic Atrioventricular Block Dogs
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概要
- 論文の詳細を見る
Pharmacokinetics of pilsicainide transdermal patch and its electropharmacological effects were simultaneously assessed using chronic atrioventricular block dogs. After application of the patch (9.8 mg/kg), pilsicainide was continuously absorbed through the skin with a Cmax of 0.49 ± 0.13 μg/ml, while its plasma concentration was kept above the clinically reported minimum effective plasma concentration for 2 – 8 h. Inter-atrial conduction time was significantly prolonged, whereas statistically significant prolongation was not detected in the atrial effective refractory period. Prolongation of the cycle length of atrial fibrillation and anti-fibrillatory action were confirmed. Thus, pilsicainide can be absorbed transdermally to exert long-lasting electropharmacological effects leading to anti–atrial fibrillatory action.
- 社団法人 日本薬理学会の論文
- 2009-07-20
著者
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Iwasaki Hiroshi
Department of Pathology, Faculty of Medicine, Fukuoka University
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Iwasaki Hiroshi
Department Of Anesthesiology And Critical Care Medicine Asahikawa Medical College
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Sugiyama Atsushi
Department of Pharmacology, School of Medicine, Toho University, Japan
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Nakamura Yuji
Department of Pharmacology, School of Medicine, Toho University, Japan
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Nakamura Yuji
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Satoh Y
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Takahara Akira
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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SHINKAI Norihiro
Research Department, Saitama Daiichi Pharmaceutical Co., Ltd.
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Satoh Yoshioki
Department of Pharmacology, Yamanashi Medical University
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Shinkai Norihiro
Research & Development Department Nipro Patch Co. Ltd.
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Satoh Yoshioki
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Iwasaki Hiroshi
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Takahara Akira
Department Of Internal Medicine National Kawatana Hospital
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NAGAI Takeshi
Research & Development Department, Nipro Patch Co., Ltd.
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Sugiyama Atsushi
Department Of Pharmacology Yamanashi Medical University
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Sugiyama A
Department Of Pharmacology Yamanashi Medical University
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Nagai Takeshi
Research & Development Department Nipro Patch Co. Ltd.
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Nakamura Yuji
Department Of Materials Engineering Graduate School Of Engineering The University Of Tokyo:crest Jap
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Nakamura Yuji
Department Of Anesthesiology Shimane Medical University
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Sugiyama Atsushi
Department Of Pharmacology Yamanashi Medical College
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Sugiyama Atsushi
Department Of Pharmacology. University Of Yamanashi Yamanashi Research Center Of Cliniacl Pharmacolo
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Sugiyama Atsushi
Department Of Chemistry College Of Science Rikkyo University
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Nakamura Yuji
Department Of Agricultural Chemistry Faculty Of Agriculture Kyushu University
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Aikawa Tokiko
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Sugiyama Atsushi
Department Of Pharmacology School Of Medicine Toho University
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Sugiyama Atsushi
Department of Biotechnology, Faculty of Engineering, Kansai University
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Takahara Akira
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Toho University
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