Prognostic Factors for Renal Amyloidosis:A Clinicopathological Study Using Cluster Analysis
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概要
- 論文の詳細を見る
Objective: There is no standardized therapy for renal amyloidosis, which shows rapid progression and poor prognosis. Here, we used cluster analysis to examine the correlation between amyloid-related renal damage and prognosis, and determined the clinicopathological prognostic factors for renal amyloidosis. Methods and Patients: We analyzed 125 patients with renal amyloidosis (men/women: 43/82; mean age at renal biopsy: 58.8±11.1 years, ±SD; range: 21-78 years). Cluster analysis was performed using clinical parameters, renal histological findings, type of renal amyloidosis, and follow-up data. We also analyzed survival data. Results: We divided 125 cases (prognosis was checked in 97 [77.6%] cases) into three groups by cluster analysis. In the cluster groups, accelerated progression correlated with serum creatinine (s-Cr) levels at renal biopsy and histological grade of renal damage by amyloid deposition (p<0.0001). The most important prognostic factors were glomerular, tubulointerstitial, and vascular lesions induced by amyloid deposition at biopsy (p<0.0001). We also found that amyloid-A (AA) type amyloidosis correlated is more significantly with amyloid-mediated vascular (P=0.0010) and tubulointerstitial lesions (p=0.0705) than with amyloid-L (AL) type amyloidosis. Proteinuria and nephrotic syndrome were more severe in AL than AA amyloidosis (p=0.0836). The 10-year individual survival rate was about 20%, and most deaths were due to cardiovascular disease and infection. Conclusion: Our results indicate that the quantity of amyloid deposition in the kidney, and the extent of glomerular, tubulointerstitial, and vascular damage are significant renal prognostic factors in amyloidosis.
- 社団法人 日本内科学会の論文
著者
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Iwasaki Hiroshi
Department Of Anesthesiology And Critical Care Medicine Asahikawa Medical College
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Abe Yasuhiro
Division Of Nephrology And Rheumatology Department Of Internal Medicine Fukuoka University School Of
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Murata Toshiaki
Division Of Nephrology And Rheumatology Department Of Internal Medicine Fukuoka University School Of
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Kaneoka Hidetoshi
Division Of Nephrology And Rheumatology Department Of Internal Medicine Fukuoka University School Of
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Takebayashi Shigeo
Department Of Pathology Fukuoka University School Of Medicine
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Ogahara Satoru
Division Of Nephrology And Rheumatology Department Of Internal Medicine Fukuoka University School Of
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Sato Hiroshi
Division Of Cardiology Tsukazaki Memorial Hospital
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Takeda Seiji
Division Of Nephrology And Rheumatology Department Of Internal Medicine Fukuoka University School Of
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Sasatomi Yoshie
Division Of Nephrology And Rheumatology Department Of Internal Medicine Fukuoka University School Of
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Saito Takao
Division Of Internal Medicine Itoigawa General Hospital
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TAKEBAYASHI Shigeo
Department of Pathology, Fukuoka University School of Medicine
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Chiba Yoshiro
Division of Nephrology, Hypertension & Endocrinology, Tohoku University Hospital
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Ogahara Satoru
Division of Nephrology & Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine
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Sasatomi Yoshie
Division of Nephrology & Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine
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Chiba Yoshiro
Division of Nephrology, Hypertension & Endocrinology, Tohoku University Hospital
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Murata Toshiaki
Division of Nephrology & Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine
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Saito Takao
Division of Nephrology & Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine
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Kaneoka Hidetoshi
Division of Nephrology & Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine
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