肝P450等の薬物代謝酵素活性を指標とした日本発新規ヒト型モデル動物"マイクロミニブタ"の非臨床試験における高い将来性

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概要

• 論文の詳細を見る
• 2009-08-25

著者

• Yamazaki Hiroshi

  Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University

• SHIMIZU Makiko

  Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University

• MURAYAMA Norie

  Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University

• Murayama Norie

  Laboratory Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical University

• Murayama Norie

  昭和薬科大学 薬物動態学研究

• KANEKO Naoki

  Fuji Micra Inc.

• HORIUCHI Kana

  Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University

• OHYAMA Katsuhiro

  Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University

• ITO Katzuhiko

  Fuji Micra Inc.

• Horiuchi Kana

  Laboratory Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical University

• Murayama Norie

  Lab. Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical Univ.

• Shimizu Makiko

  Showa Pharmaceutical University

• Shimizu M

  Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University

• Shimizu Makiko

  Lab. Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical Univ.

• Shimizu Makiko

  Laboratory Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical University

• Shimizu Makiko

  Laboratory For Genetics Of Allergic Diseases Snp Research Center Riken

• Saito Miwako

  Lab. Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical Univ.

• Yamazaki Hiroshi

  Laboratory Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical University

• Ohyama Katsuhiro

  Laboratory Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical University

関連論文

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• Human blood concentrations of dichlorodiphenyltrichloroethane (DDT) extrapolated from metabolism in rats and humans and physiologically based pharmacokinetic modeling
• 肝P450等の薬物代謝酵素活性を指標とした日本発新規ヒト型モデル動物"マイクロミニブタ"の非臨床試験における高い将来性
• 日本人肝におけるフラビン含有モノオキシゲナーゼ3発現の個人差 : 肝転写因子との相関
• Complex Mechanism Underlying Transcriptional Control of the Haplotyped Flavin-containing Monooxygenase 3 (FMO3) Gene in Japanese : Different Regulation between Mutations in 5'-Upstream Distal Region and Common Element in Proximal Region
• Sulfating-Activity and Stability of cDNA-Expressed Allozymes of Human Phenol Sulfotransferase, ST1A31 (^Arg) and ST1A32 (^His), Both of Which Exist in Japanese as Well as Caucasians^1
• 高気圧酸素療法を施した患者の抗がん薬カルボプラチン血漿中濃度測定用HPLC法について
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• An association study of asthma and related phenotypes with polymorphisms in negative regulator molecules of the TLR signaling pathway
• ラット肝臓ミクロソームにおける, 硫酸マグネシウムによるチトクロームP450 2C, 3Aの活性化およびブピバカインの酸化代謝に及ぼす影響
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• Glucuronidation of Propofol and Its Analogs by Human and Rat Liver Microsomes
• Testicular Toxicity of Mono-n-Butyl Phthalate and Related Phthalates on Bound Iron in Rat Red Blood Cells
• Possible Origin of Rat Testicular Atrophy Induced by Di-n-Butyl Phthalate : Changes in the Activities of Some Enzymes during Rat Testis Perfusion under a Hypoxic Condition and with Mono-n-Butyl Phthalate
• A Computer Program for Pharmacokinetics Based on Maximum Likelihood Estimation Using the Gamma Distribution with a Probability Density Function : Comparison with the Normal Distribution
• Blood Concentrations of 1,4-Dioxane in Humans after Oral Administration Extrapolated from In Vivo Rat Pharmacokinetics, In Vitro Human Metabolism, and Physiologically Based Pharmacokinetic Modeling
• Comparison of the Contributions of Cytochromes P450 3A4 and 3A5 in Drug Oxidation Rates and Substrate Inhibition
• AN ENZYMIC MECHANISM FOR MUTAGENIC ACTIVATION OF CARCINOGENIC AMINOAZO DYES
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