Electrophysiological, Anatomical and Histological Remodeling of the Heart to AV Block Enhances Susceptibility to Arrhythmogenic Effects of QT-Prolonging Drugs

スポンサーリンク

概要

• 論文の詳細を見る

• The present study was designed to investigate what kinds of adaptation occurred in the canine chronic AV block model, which has been used to study torsade de pointes (TdP). Dogs at 7 – 10 days (acute phase) and 28 – 56 days (chronic phase) after AV block were assessed. Ventricular effective refractory period and monophasic action potential duration were prolonged in chronic animals compared with acute animals; moreover the electrically vulnerable period was prolonged in chronic animals. Non-specific IKr channel blocker cisapride (1 and 10 mg/kg, p.o.) was administered without anesthesia to estimate the feasibility of QT prolongation. In chronic animals, QT prolongation followed by TdP was induced in one dog by the low dose and in all by the high dose, which was not observed in acute animals. MR images indicated increases of diameter and wall thickness of both ventricles in chronic animals. The degree of hypertrophy was prominent in the right ventricular wall and septal wall. Heart weight of the chronic animals was 1.7 times greater than that of normal control subjects. Photo- and electron-micrograph analyses showed myocardial cell hypertrophy with parallel increases of collagen fiber and extracellular space in chronic animals. These electrophysiological, anatomical and histological adaptations may predispose the chronic AV block heart to drug-induced QT prolongation with enhanced risk of re-entry and early afterdepolarization, leading to the onset of TdP.

• 社団法人 日本薬理学会の論文
• 2002-03-01

著者

• Ishida Yuko

  Department of Forensic Medicine, Wakayama Medical University

• HASHIMOTO Keitaro

  Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, Universit

• Sugiyama Atsushi

  Department of Pharmacology, School of Medicine, Toho University, Japan

• Akie Yasuki

  Department of Pharmacology, School of Medicine, Toho University, Japan

• Satoh Y

  Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University

• AOKI Shigeki

  Department of Radiology, The University of Tokyo Hospital

• Satoh Yoshioki

  Department of Pharmacology, Yamanashi Medical University

• Satoh Yoshioki

  Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University

• Akie Yasuki

  Fuji Biomedix Co. Ltd.

• Akie Yasuki

  Department Of Pharmacology Yamanashi Medical University

• Ishida Yuko

  Department Of Pharmacology Yamanashi Medical University

• Ishida Yuko

  Department Of Forensic Medicine Wakayama Medical University

• Sugiyama Atsushi

  Department Of Pharmacology Yamanashi Medical University

• HORI Masaaki

  Department of Radiology, Yamanashi Medical University

• Hori Masaaki

  Department Of Radiology Yamanashi Medical University

• Aoki Shigeki

  Department Of Radiology Juntendo University School Of Medicine

• Akie Yasuki

  Fuji Biomedix Co. Ltd

• KOBAYASHI Yoshihiko

  Second Department of Pathology, Yamanashi Medical University

• Hashimoto Keitaro

  Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University

• Hori Masaaki

  Department Of Radiology University Of Yamanashi

• Hashimoto Keitaro

  Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University

• Aoki Shigeki

  Department Of Radiology Yamanashi Medical University

• Aoki Shigeki

  Department Of Radiology Faculty Of Medicine The University Of Tokyo

• Kobayashi Yoshihiko

  Second Department Of Pathology Yamanashi Medical University

• Sugiyama Atsushi

  Department Of Pharmacology. University Of Yamanashi Yamanashi Research Center Of Cliniacl Pharmacolo

• Sugiyama Atsushi

  Department Of Chemistry College Of Science Rikkyo University

• Sugiyama Atsushi

  Department Of Pharmacology School Of Medicine Toho University

• Akie Yasuki

  Department Of Pharmacology School Of Medicine Toho University

• Aoki Shigeki

  Department Of Hepato-biliary-pancreatic Surgery Tokyo Medical And Dental University

• HASHIMOTO Keitaro

  Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi

• HASHIMOTO Keitaro

  Department of Phamacology, Yamanashi Medical University

• Sugiyama Atsushi

  Department of Biotechnology, Faculty of Engineering, Kansai University

関連論文

• Immunohistochemical Analysis of CXCR4 Expression in Fibrohistiocytic Tumors
• PRACTICAL APPLICATION OF GUINEA PIG TELEMETRY SYSTEM FOR QT EVALUATION
• Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research:In Vivo Proarrhythmia Models of Drug-Induced Long QT Syndrome: Development of Chronic Atrioventricular Block Model of Microminipig
• Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research:Preface
• In Vivo Electropharmacological Effects of Amiodarone and Candesartan on Atria of Chronic Atrioventricular Block Dogs
• Comparison of Four Rate-Correction Algorisms for the Ventricular Repolarization Period in Assessing Net Effects of I_ Blockers in Dogs
• OJ-071 Chronic Atrioventricular Block Abbreviated the Action Potential Duration of Canine Pulmonary Vein Myocardium(Arrythmia, basic(02)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Analysis of Arrhythmogenic Profile in a Canine Model of Chronic Atrioventricular Block by Comparing In Vitro Effects of the Class III Antiarrhythmic Drug Nifekalant on the Ventricular Action Potential Indices Between Normal Heart and Atrioventricular Bloc
• Diffusion abnormality in posterior cingulate fiber tracts in Alzheimer's disease : tract-specific analysis
• Diffusion tensor imaging of the brain : effects of distortion correction with correspondence to numbers of encoding directions
• 3T PROPELLER diffusion tensor fiber tractography : a feasibility study for cranial nerve fiber tracking
• Flexible ex vivo phantoms for validation of diffusion tensor tractography on a clinical scanner
• Quantitative Evaluation of the Pyramidal Tract Segmented by Diffusion Tensor Tractography : Feasibility Study in Patients with Amyotrophic Lateral Sclerosis
• The Optimal Trackability Threshold of Fractional Anisotropy for Diffusion Tensor Tractography of the Corticospinal Tract
• Development of Intraarterial Contrast-enhanced 2D MRDSA with a 0. 3 Tesla Open MRI System
• Effect of the New Class III Antiarrhythmic Drug MS-551 and d-Sotalol on Canine Coronary Ligation-Reperfusion Ventricular Arrhythmias
• In Vivo Antiarrhythmic Profile of AP-792 Assessed in Different Canine Arrhythmia Models
• Comparison of the Electropharmacological Effects of Verapamil and Propranolol in the Halothane-Anesthetized In Vivo Canine Model Under Monophasic Action Potential Monitoring
• Severe brainstem compression by an unruptured giant vertebral aneurysm : An autopsy case
• Pravastatin Prevents Arrhythmias Induced by Coronary Artery Ischemia/Reperfusion in Anesthetized Normocholesterolemic Rats
• P6-14 Development of telemetry system for QT evaluation in guinea pigs(LIVER AND DIGESTIVE SYSTEM/CIRCULATORY SYSTEM-1/DEVELOPMENT AND REPRODUCTION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
• Effects of Intravenous Anesthetics on Function and Metabolism in the Reperfused Working Rat Heart
• Constitutional Rho-Kinase Regulates the Electrophysiological and Mechanical Function of the Heart Besides the Coronary Vascular Tone
• Cardiac Effects of a Selective Rho-Associated Kinase Inhibitor, Y-27632, Assessed in Canine Isolated, Blood-Perfused Heart Preparations
• Effects of Sphingosine 1-Phosphate, a Naturally Occurring Biologically Active Lysophospholipid, on the Rat Cardiovascular System
• Antiarrhythmic and Proarrhythmic Effects of Sematilide in Canine Ventricular Arrhythmia Models
• Effects of KB-R9032, a new Na^+/H^+ Exchange Inhibitor, on Canine Coronary Occlusion/Reperfusion-Induced Ventricular Arrhythmias
• Block of Na exchangers on ischemia induced arrhythmias
• Effects of Acute Intravenous Administration of Pentamidine, a Typical hERG-Trafficking Inhibitor, on the Cardiac Repolarization Process of Halothane-Anesthetized Dogs
• Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice
• DEVELOPMENT OF TELEMETRY SYSTEM IN THE COMMON MARMOSET : CARDIOVASCULAR EFFECTS OF ASTEMIZOLE AND NICARDIPINE
• 0453 INHIBITION OF Na^+/H^+ EXCHANGE SUPPRESSES BOTH REBOUND RECOVERY OF MYOCARDIAL CREATINE PHOSPHATE (Cr-P) AND LETHAL ARRHYTHMIAS DURING REPERFUSION AFTER A BRIEF ISCHEMIA
• Simultaneous Assessment of Pharmacokinetics of Pilsicainide Transdermal Patch and Its Electropharmacological Effects on Atria of Chronic Atrioventricular Block Dogs
• Comparison of Electropharmacological Effects of Bepridil and Sotalol in Halothane-Anesthetized Dogs
• OJ-006 Comparison of Electropharmacological Effects of Sotalol and Bepridil Assessed in the in Vivo Canine Heart(Cardiovascular pharmacology, basic/clinical-2 (H) OJ1,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japan
• Purification and Properties of an Aminopeptidase from a Protamine-degrading Marine Bacterium
• Microbial Transformation of Carbazole to Indole-3-acetic Acid by Flavobacterium sp. OCM-1
• Clinical utility of quantitative RT-PCR targeted to α1,4-N-acetylglucosaminyltransferase mRNA for detection of pancreatic cancer
• Suppressive effect of rice extract on Helicobacter pylori infection in a Mongolian gerbil model
• Eradication of Helicobacter pylori decreases mucosal alterations linked to gastric carcinogenesis in Mongolian gerbils
• Dissolution Process of Copper Sulfate into Water in a Heterogeneous Vertical Magnetic Field
• P400 CAN THE MAP TECHNIQUE BE APPLIED TO DETECT DELAYED AFTERDEPOLARIZATION ? : ELECTROPHYSIOLOGICAL AND PHARMACOLOGICAL EVIDENCE
• 0901 EFFECT OF A CLASS III ANTIARRHYTHMIC DRUG ON REFRATORY PERIOD. : DEMONSTRATION OF REVERSE USE DEPENDENCY ASSESSED BY MONOPHASIC ACTION POTENTIALS.
• -P159- Effects of Sodium and Calcium Channel Blockers on Monophasic Action Potential(MAP)Recordings Assessed by the Canine Isolated, Blood-Perfused Ventricular Tissue Preparation(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATIO
• -P157- Electrophysiological and Pharmacological Characteristics of Digitalis-induced Triggered Activity in the Canine Isolated, Blood-perfused Ventricular Muscle Preparation.(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SO
• Effect of the Sarcolemmal K_ Channel Blocker HMR1098 on Arrhythmias Induced by Programmed Electrical Stimulation in Canine Old Myocardial Infarction Model : Comparison With Glibenclamide
• KB-R7943, a Na^+/Ca^ Exchange Inhibitor, Does Not Suppress Ischemai/Reperfusion Arrhythmias nor Digitalis Arrhythmias in Dogs
• Inhibitory Effects of Pre-ischemic and Post-ischemic Treatment With FR 168888, a Na^+/H^+ Exchange Inhibitor, on Reperfusion-Induced Ventricular Arrhythmias in Anesthetized Rat
• Slowing Na^+ Channel Inactivation Prolongs QT Interval and Aggravates Adrenaline-Induced Arrhythmias
• The roles of IL-1 receptor antagonist in skin wound healing
• Comparison of four types of rate-correcting methods for QT interval : which methods can better reflect the delayed rectifier K^+ channel-inhibition in the halothane-anesthetized guinea pigs?(Circulatory system, Proceedings of the 32nd Annual Meeting)
• Comparison of the sensitivity of various in vivo animal models for detecting the drug-induced QT interval prolongation(General toxicology, Test methods (1), Proceedings of the 32nd Annual Meeting)
• A Red Wine Vinegar Beverage can Inhibit the Renin-Angiotensin System : Experimental Evidence in Vivo(Pharmacology)
• The Endothelium-Dependent Vasodilator Action of a New Beverage Made of Red Wine Vinegar and Grape Juice(Pharmacology)
• Dangerous QT Prolongation Can be Assayed with Two Types of In Vivo Models ; Halothane-Anesthetized Dog and Chronic Atrioventricular Block Dog(Cardiovascular Pharmacology, Basic/Clinical 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation
• The Antipsychotic and Antiemetic Drug Prochlorperazine Delays the Ventricular Repolarization of the In Situ Canine Heart
• Electropharmacological Effects of a Spironolactone Derivative, Potassium Canrenoate, Assessed in the Halothane-Anesthetized Canine Model
• Cardiovascular Effects of an L/N-type Ca^ Channel Blocker Cilnidipine Assessed in the Chronic Atrioventricular Conduction Block Dogs
• PE-353 Mexiletine Decreased the Ventricular Electrical Vulnerability in the Canine Model of Sparfloxacin-Induced Long QT Syndrome(Cardiovascular Pharmacology, Basic/Clinical 3 (H) : PE60)(Poster Session (English))
• OE-275 A Spironolactone Derivative, Potassium Canrenoate, Prolongs the QT Interval but Shortens the Electrically Vulnerable Period of In Vivo Canine Hearts(Cardiovascular Pharmacology, Basic/Clinical 1 (H) : OE34)(Oral Presentation (English))
• The QT-Prolonging Effects of a Histamine H1 Receptor Antagonist Terfenadine Assessed in the In Vivo Canine Heart Model: Comparison of the Rate-Correcting Methods for the Ventricular Repolarization Periods
• Relationship Between Phosphodiesterase Inhibition Induced by Several Kampo Medicines and Smooth Muscle Relaxation of Gastrointestinal Tract Tissues of Rats
• N- Plus L-Type Ca^ Channel Blocker Cilnidipine Decreased the Proarrhythmic Potential of the Canine Sudden Cardiac Death Model
• Effects of Clinically Available Blended Herbal Medicines (Kampo Extracts) on the Phosphodiesterase Activity in Rat Hearts
• Cardiovascular and Adenylate Cyclase Stimulating Effects of Colforsin Daropate, a Water-Soluble Forskolin Derivative, Compared With Those of Isoproterenol, Dopamine and Dobutamine
• Effects of Disopyramide and Mexiletine on the Terminal Repolarization Process of the In Situ Heart Assessed Using the Halothane-Anesthetized In Vivo Canine Model
• Comparison of the In Vivo Electrophysiological and Proarrhythmic Effects of Amiodarone With Those of a Selective Class III Drug, Sematilide, Using a Canine Chronic Atrioventricular Block Model
• Effects of a Novel Vesamicol Receptor Ligand, m-(Iodobenzyl)trozamicol, on the Canine Isolated, Blood-Perfused Atrioventricular Node Preparation
• -0933- Measurement of Adenylyl Cyclase Activity in the Contractile and Conductive Elements of the Canine Heart : Comparison of the Regional Adenylyl Cyclase Activity after the Treatment by Purinergic or Cholinergic Agonists.(PROCEEDINGS OF THE 59th ANNUAL
• Measurements of Cardiac Ion Channel Subunits in the Chronic Atrioventricular Block Dog
• Development of a Halothane-Adrenaline Arrhythmia Model Using In Vivo Guinea Pigs
• Effect of High Glucose Concentration on Mitochondrial Metabolism in Neuronal Cells
• 一次救命のための新たな携帯型人工呼吸器の開発
• Quantitative Analysis of the Antiarrhythmic Effect of Drugs on Canine Ventricular Arrhythmias by the Determination of Minimum Effective Plasma Concentrations : Pharmacology and Clinical Evaluation of Antiarrhythmic Drugs
• PERIPHERAL EFFECTS OF GUANFACINE COMPARED TO THOSE OF CLONIDINE THE DOG
• Cardiovascular Effects of Orally Administered HNS-32, an Originally Synthesized Azulene-1-carboxamidine Derivative, Assessed in the In Vivo Rat Model
• Pharmacological and Electrophysiological Characterization of Junctional Rhythm During Radiofrequency Catheter Ablation of the Atrioventricular Node : Possible Involvement of Neurotransmitters From Autonomic Nervous System
• Electrophysiological, Anatomical and Histological Remodeling of the Heart to AV Block Enhances Susceptibility to Arrhythmogenic Effects of QT-Prolonging Drugs
• Molecular Mechanisms of Cardiostimulatory Effects of Sildenafil
• Effects of Sildenafil (Viagra TM) on the Cyclic AMP Hydrolyzing Phosphodiesterase Activity in the Canine Heart Assessed Using a Modified Enzymatic Fluorometric Assay Technique
• Effects of ONO : 2235, an Aldose Reductase Inhibitor, on Muscarinic Receptors and Contractile Response of the Urinary Bladder in Rats with Streptozotocin : Induced Diabetes
• Physical and Pharmacological Regulation of Atrial Natriuretic Peptide Release from the Isolated, Blood-Perfused Right Atrium of the Dog
• Clinical Study of Delapril Hydrochloride in Patients with Acute Myocardial Infarction: Effects of Early ACE Inhibition foflowing Effective Thrombofytic Coronary Recanalizati
• Enzymatic Fluorometric Assay for Adenylyl Cyclase Activity Comparison with Radioimmunoassay and Original [alpha-32P] ATP Salomon Method
• Effects of Mexiletine on the Canine Cardiovascular System Complicating Cisapride Overdose: Potential Utility of Mexiletine for the Treatment of Drug-Induced Long QT Syndrome
• Effect of Magnesium Sulfate on the Haloperidol-Induced QT Prolongation Assessed in the Canine In Vivo Model Under the Monitoring of Monophasic Action Potential
• Effects of a Class III Antiarrhythmic Drug, Dofetilide, on the In Situ Canine Heart Assessed by the Simultaneous Monitoring of Hemodynamic and Electrophysiological Parameters
• Role of Circulating Catecholamines in Reflex Tachycardia Induced by Ca Antagonists
• Cardiac Effects of Clinically Available Kampo Medicine Assessed With Canine Isolated, Blood-Perfused Heart Preparations
• EFFECTS OF PROSTAGLANDINS ON LATE CORONARY LIGATION ARRHYTHMIAS IN THE DOG
• Famotidine neither affects action potential parameters nor inhibits human ether-a-go-go-related gene (hERG) K^+ current
• Characterization of the Halothane-Anesthetized Guinea-Pig Heart as a Model to Detect the K^+ Channel Blocker-Induced QT-Interval Prolongation(Pharmacology)
• PJ-719 Beat-to-beat Variability of Ventricular Repolarization Period Can Predict Onset of Acquired Long QT Syndrome(Arrhythmia, basic-6 (A) PJ121,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-345 Long-term Blockade of N-type Ca^ Channels Reversed the Ventricular Electrical Remodeling in the Canine Model of Long QT Syndrome(Cardiovascular pharmacology, basic/clinical-4 (H) PJ58,Poster Session (Japanese),The 70th Anniversary Annual Scient
• Halothane Sensitizes the Guinea-Pig Heart to Pharmacological I_ Blockade : Comparison With Urethane Anesthesia
• A Simple In Vivo Atrial Fibrillation Model of Rat Induced by Transesophageal Atrial Burst Pacing
• ON THE HISTAMINE RECEPTOR OF THE CANINE MYOCARDIUM AND CORONARY VASCULATURE
• Cardiac Effects of Salvia Miltiorrhiza/Dalbergia Odorifera Mixture, an Intravenously Applicable Chinese Medicine Widely Used for Patients With Ischemic Heart Disease in China
• Cardiovascular Effects of L-158,809, a New Angiotensin Type 1 Receptor Antagonist, Assessed Using the Halothane-Anesthetized In Vivo Canine Model
• Acute Electropharmacological Effects of Intravenously Administered Amiodarone Assessed in the In Vivo Canine Model

もっと見る 閉じる

スポンサーリンク