Development of Intraarterial Contrast-enhanced 2D MRDSA with a 0. 3 Tesla Open MRI System

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概要

• 論文の詳細を見る

• Purpose: The purpose of this study was to develop a new technique for a high temporal resolution two-dimensional MR digital subtraction angiography (2D MRDSA) sequence under intraarterial injection of contrast material to permit the visualization of vascular anatomy and hemodynamics. Methods: 2D MRDSA was imaged on a 0.3T open MR scanner with a T1-weighted fast gradient echo sequence. The phantom study examined vials containing gadolinium (Gd) solutions ranging in concentration from 0.5 mmol/L to 100 mmol/L. Repetition time and echo time were fixed at minimal values in order to achieve high temporal resolution, and only the flip angle was changed in 10-degree increments between 10 and 90 degrees. The in vivo study examined a brachial artery of a human volunteer. MRDSA images were acquired continuously during intraarterial injections of Gd solutions ranging in concentration from 0.5 mmol/L to 100 mmol/L. The subtracted images were displayed on the monitor in real time at a frame rate of one frame per second and evaluated to determine the optimal concentration of contrast material. Results: In the phantom study, a 10-mmol/L Gd concentration with a flip angle of 50°-90° and a 25-mmol/L Gd concentration with a flip angle of 60°-90° showed high signal-to-noise ratios. In the human brachial artery experiment, the forearm arteries were well visualized when solutions of 5-50 mmol/L Gd concentration were used. The 10- and 25-mmol/L Gd concentrations were considered optimal. The palmar digital arteries were also visualized. Higher Gd concentrations showed a paradoxical signal increase when diluted by blood. Conclusion: We successfully developed an intraarterial contrast-enhanced 2D MRDSA sequence. With appropriate settings of imaging parameters and Gd concentrations, we obtained acceptable vessel visualization in the human study. The low Gd concentration for optimal visualization permits repeated intraarterial injections. This technique can be a useful tool for investigating the vascular anatomy and hemodynamics required for MR-guided vascular interventions.

• 日本磁気共鳴医学会の論文
• 2003-07-01

著者

• 大友 邦

  山梨大学 医学部放射線科

• Abe Osamu

  Department of Pediatrics, Nihon University School of Medicine

• Ohtomo Kuni

  Department Of Radiology Faculty Of Medicine University Of Tokyo

• Ohtomo Kuni

  Department Of Radiology School Of Medicine The University Of Tokyo

• Ohtomo Kuni

  Ntt東日本関東病院

• Abe Osamu

  Department Of Radiology The University Of Tokyo

• HAYASHI Naoto

  Department of Radiology, Graduate School of Medicine, University of Tokyo

• AOKI Shigeki

  Department of Radiology, The University of Tokyo Hospital

• MASUMOTO Tomohiko

  Department of Radiology, The University of Tokyo Hospital

• MORI Harushi

  Department of Radiology, The University of Tokyo Hospital

• ABE Takayuki

  Hitachi Medical Corporation

• TAKAHASHI Tetsuhiko

  Hitachi Medical Corporation

• 青木 茂樹

  Department Of Radiology Juntendo University School Of Medicine

• Ohtomo Kuni

  Department Of Radiology Graduate School Of Medicine University Of Tokyo

• Ohtomo Kuni

  Department Of Radiology The University Of Tokyo Graduate School Of Medicine

• Ohtomo Kuni

  Department Of Radiology Faculty Of Medicin University Of Tokyo

• Mori Harushi

  Department Of Radiology The University Of Tokyo Hospital

• Mori Harushi

  Department Of Radiology Graduate School Of Medicine University Of Tokyo

• Hayashi Naoto

  Department Of Computational Diagnostic Radiology And Preventive Medicine The University Of Tokyo

• Hayashi Naoto

  Department Of Radiology Faculty Of Medicine University Of Tokyo

• Abe Osamu

  Department Of General Pediatrics Nihon University Nerima Hikarigaoka Hospital Nihon University Schoo

• Aoki Shigeki

  Department Of Radiology Juntendo University School Of Medicine

• Masumoto Tomohiko

  Department Of Radiology The University Of Tokyo Hospital

• Masumoto Tomohiko

  Department Of Radiology University Of Tokyo School Of Medicine

• Masumoto Tomohiko

  Department Of Radiology University Of Tokyo

• 増本 智彦

  筑波大学大学院人間総合科学研究科

• Aoki Shigeki

  Department Of Radiology Faculty Of Medicine The University Of Tokyo

• Aoki Shigeki

  Department Of Radiology Juntendo University

• Aoki Shigeki

  Department Of Hepato-biliary-pancreatic Surgery Tokyo Medical And Dental University

• HAYASHI Naoto

  Department of Chemistry, College of Arts and Sciences, The University of Tokyo

• MASUMOTO Tomohiko

  Department of Intervention and Radiology, Faculty of Medicine, University of Tsukuba

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