PERIPHERAL EFFECTS OF GUANFACINE COMPARED TO THOSE OF CLONIDINE THE DOG
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概要
- 論文の詳細を見る
Comparative studies of the antihypertensive agents, guanfacine and clonidine, on their peripheral effects were performed using normotensive canine preparations. On the peripheral vascular beds, both drugs constricted cerebral, renal and femoral vasculatures, but there were no decreases in the renal blood flow. This vasoconstriction was blocked by phentolamine, and guanfacine was about 3 times less potent than clonidine. Both drugs contracted the canine nictitating membrane, and had no effect on the ganglionic transrnission in the cervical syrnpathetic ganglion. Qualitatively different effects were observed in their effects on renal function. Guanfacine slightly increased the urinary volume and Na excretion, while clonidine increased the urinary volume and K excretion. All these peripheral effects do not seem to be responsible for their hypotensive effect .
- 社団法人日本循環器学会の論文
- 1980-12-20
著者
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HASHIMOTO Keitaro
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, Universit
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Hashimoto Toyozo
Department of Cardiology, Jichi Medical School
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IMAI Shoichi
Department of Pharmacology, Niigata University School of Medicine
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Imai Shoichi
Department Of Phamacology Niigata University School Of Medicine
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NAKAGAWA YOSHITO
Department of Pharmacy, Yamagata University Hospital
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TAKEDA Keisuke
Department of Applied Chemistry, Faculty of Engineering, Gunma University
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TSUKADA TOKUMASA
Department of Pharmacology, Niigata University School of Medicine
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Tsukada Tokumasa
Department Of Pharmacology Niigata University School Of Medicine
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Nakagawa Yoshito
Department Of Pharmacology Niigata University School Of Medicine
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Takeda Keisuke
Department Of Applied Chemistry Faculty Of Engineering Gunma University
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Hashimoto Toyozo
Department Of Cardiology And Internal Medicine
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Hashimoto Toyozo
Department Of Pharmacology Niigata University School Of Medicine
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Hashimoto Keitaro
Department Of Pharmacology Niigata University School Of Medicine
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HASHIMOTO Keitaro
Department of Phamacology, Yamanashi Medical University
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TAKEDA Keisuke
Department of Pharmacology, Niigata University School of Medicine
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