CORONARY VASODILATATION AND ADRENERGIC RECEPTORS IN THE DOG HEART AND CORONARY
スポンサーリンク
概要
- 論文の詳細を見る
The question of whether the coronary blood vessels contain an intrinsic adrenergic mechanism for vasodilatation of physiological significance has been examined in the canine heart-lung preparation with a donor by studying the response of the coronary vessels to epinephrine, norepinephrine, isoproterenol and salbutamol in combination with practolol. To differentiate the vasodilatation mediated through adrenoceptors in the coronary vessels from that resulting from an increase in the myocardial O<SUB>2</SUB> consumption, a special method of analysis was developed based on the linear relation between the coronary flow and the myocardial O<SUB>2</SUB> consumption. It was found that all four compounds produced an increase in the coronary flow attributable to an increased myocardial O<SUB>2</SUB> consumption. Epinephrine and norepinephrine produced a decrease in the coronary flow after practolol which completely abolished the increase in the myocardial O<SUB>2</SUB> consumption as well as the positive inotropic and chronotropic effects produced by these compounds, while isoproterenol and salbutamol produced an increase. These results indicate that adrenergic β-receptor exists in the coronary subserving a vasodilatation. However, the vasodilatation through this mechanism is of minor importance under physiological conditions and becomes completely masked in the presence of an overwhelmingly strong vasodilatation consequent to an increase in the myocardial O<SUB>2</SUB> consumption.
- 社団法人 日本薬理学会の論文
著者
-
IMAI Shoichi
Department of Pharmacology, Niigata University School of Medicine
-
Imai Shoichi
Department Of Phamacology Niigata University School Of Medicine
-
Katano Yumi
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
-
TAKEDA Keisuke
Department of Applied Chemistry, Faculty of Engineering, Gunma University
-
OTORII Takeshi
Department of Pharmacology, Niigata University School of Medicine
-
Takeda Keisuke
Department Of Applied Chemistry Faculty Of Engineering Gunma University
-
Otorii Takeshi
Department Of Pharmacology Niigata University Schcol Of Medicine
-
OTORII Takeshi
Department of Phamacology, Niigata University School of Medicine
-
KATANO Yumi
Department of Pharmacology, Niigata University School of Medicine
関連論文
- HYPOTENSIVE MECHANISMS OF CARVEDILOL
- Three Binding Sites of ^I-Iodocyanopindolol, i.e. β_1,β_2-Adrenergic and 5HT_-Serotonergic Receptors in Rat Brain Determined by the Displacement and Scatchard Analysis
- Synthesis of Ladder and Cage Silsesquioxanes from 1,2,3,4-Tetrahydroxycyclotetrasiloxane
- Quantitative Analysis of the Antiarrhythmic Effect of Drugs on Canine Ventricular Arrhythmias by the Determination of Minimum Effective Plasma Concentrations : Pharmacology and Clinical Evaluation of Antiarrhythmic Drugs
- PERIPHERAL EFFECTS OF GUANFACINE COMPARED TO THOSE OF CLONIDINE THE DOG
- CANINE EFFECTIVE PLASMA DISOPYRAMIDE CONCENTRATION IN TWO-STAGE CORONARY LIGATION VENTRICULAR ARRHYTHMIA : Antiarrhythmic Drugs : IV Auditorium : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- ON THE EXISTENCE OF METABOLIC α-ADRENERGIC RECEPTOR IN THE MYOCARDIUM
- CORONARY VASODILATATION AND ADRENERGIC RECEPTORS IN THE DOG HEART AND CORONARY
- BINDING CHARACTERISTICS OF 3H-DIHYDROALPRENOLOL TO β-ADRENOCEPTORS OF RAT HEART TREATED WITH NEURAMINIDASE
- EFFECT OF NITROGLYCERIN ON Ca EFFLUX IN THE CORONARY ARTERY
- ANTIHYPERTENSIVE EFFECTS OF β-BLOCKERS IN HYPERTENSIVE RATS
- POSITIVE INOTROPIC AND CHRONOTROPIC EFFECTS OF 8-SUBSTITUTED DERIVATIVES OF 3, 5-CYCLIC AMP
- EFFECTS OF CYCLIC AMP AND DIBUTYRYL CYCLIC AMP ON THE HEART AND CORONARY CIRCULATION
- EFFECTS OF PROSTAGLANDINS ON LATE CORONARY LIGATION ARRHYTHMIAS IN THE DOG
- A COMPARISON OF ANTIHYPERTENSIVE EFFECTS OF ATENOLOL AND PROPRANOLOL IN THE SPONTANEOUSLY HYPERTENSIVE, DOCA/SALINE HYPERTENISVE AND RENAL HYPERTENSIVE RATS
- EFFECTS OF SEVERAL BETA-BLOCKING AGENTS ON THE DEVELOPMENT OF HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS
- ON THE HISTAMINE RECEPTOR OF THE CANINE MYOCARDIUM AND CORONARY VASCULATURE
- EFFECTS OF AMINOPHYLLINE, PROXYPHYLLINE AND A PROXYPHYLLINE-MELILOTUS EXTRACT-RUTIN MIXTURE (THEOESBERIVEN) ON THE HEART AND THE CORONARY CIRCULATION
- Effects of Coronary Vasodilators on Large and Small Coronary Arteries of Dogs
- Diverse Relaxation Responses of Canine Large and Small Conductive Coronary Arteries to Glyceryl Trinitrate and Nitric Oxide on the One Hand and to 8-Bromoguanosine 3':5' Cyclic Monophosphate on the Other
- A COMPARISON OF THE DIFFERENTIAL EFFECTS OF NITROGLYCERIN, NIFEDIPINE AND PAPAVERINE ON CONTRACTURES INDUCED IN VASCULAR AND INTESTINAL SMOOTH MUSCLE BY POTASSIUM AND LANTHANUM
- Effects of Ethyl Adenosine-5-Carboxylate on the Heart and Coronary Circulation
- CARDIOTOXIC EFFECTS OF 5-FLUOROURACIL IN THE GUINEA PIG
- Effects of Piridoxilate, a Glyoxylic Acid Derivative, on the Energy Metabolism of the Heart
- EFFECTS OF CATECHOLAMINES ON THE MYOCARDIAL REDOX POTENTIAL
- EFFECTS OF BETA-ADRENORECEPTOR BLOCKING AGENTS ON THE DESLANOSIDE-INDUCED ARRHYTHMIA AND CARDIAC ARREST IN GUINEA PIGS
- THE SUPPRESSIVE ACTIVITIES OF ALPRENOLOL AGAINST DESLANOSIDE-INDUCED CARDIOTOXICITIES IN GUINEA PIGS
- Effects of Lidocaine and Procaine on the Action Potential of Canine Sinus Nodal Cells
- Structure and Function of Inositol 1 ,4,5 : Trisphosphate Receptor
- ANTIARRHYTHMIC EFFECT OF OXPRENOLOL ON HALOTHANE-EPINEPHRINE AND CORONARY LIGATION INDUCED VENTRICULAR ARRHYTHMIAS IN BEAGLE DOGS
- Hypotensive and Vascular Effects of Labetalol in the Normotensive Rat and Dog
- ANTAGONISTIC EFFECTS OF TRIMETAZIDINE TO ADRENALINE
- ALPHA- AND BETA-BLOCKING ACTIVITIES OF RACEMATES OF LABETALOL
- DEVELOPMENT OF CORONARY COLLATERAL CIRCULATION IN MINIATURE SWINE AND EFFECTS OF SEVERAL DRUGS
- Effects of 2-Nicotinamidoethyl Nitrate on the Cardiovascular System
- Effect of l-Carnitine Chloride and Its Acetyl Derivative on the Electrophysiological Derangement Induced by Palmityl-l-Carnitine in Isolated Canine Ventricular Muscle
- Beneficial effects of diltiazem on the ischemic derangements of the myocardial metabolism assessed by 31P-NMR in the isolated perfused rat heart.
- Selectivity of bunitrolol for .BETA.1- and .BETA.2-adrenergic receptors and 5HT1B-receptors: Assessment by biphasic scatchard plots and biphasic displacement curve analysis with 125I-iodocyanopindolol and 3H-CGP12177.
- Effects of bunitrolol on adrenergic and serotonergic receptors.
- Beta-receptor blocking potencies of the three newly synthesized .BETA.-adrenergic antagonists (S-596,K-351,N-696) as assessed with the radioligand binding assay method in rat cardiac muscle membrane treated with neuraminidase.
- Displacement by .ALPHA.-adrenergic agonists and antagonists of 3H-prazosin bound to the .ALPHA.-adrenoceptors of the dog aorta and the rat brain.
- In Vitro Effects of the New Calcium Antagonist Lacidipine.
- Myocardial Na+ during Ischemia and Accumulation of Ca2+ after Reperfusion: A Study with Monesin and Dichlorobenzamil.
- Effects of deoxyribonuclease I and neuraminidase treatments on the specific binding of 3H-prazosin and 3H-quinuclidinyl benzilate (3H-QNB) to .ALPHA.-adrenergic and muscarinic receptors in rat myocardial membranes.
- Effects of cardioplegia induced by a young's solution (YNG solution) on the blood-perfused canine papillary muscle preparation.
- Enhanced responsiveness of the coronary blood vessel of the dog heart-lung preparation to PGI2 after chronic chemical sympathectomy.
- CARDIAC ACTIVE STEROIDS AND THE SLOW MUSCLE FIBRE
- Cardiotonic and coronary vasodilatatory effects of amrinone in the canine heart-lung preparation with a support dog as compared with those of dobutamine.
- Effect of carvedilol on venous return: A mechanism of reduction in blood pressure.
- On the Mechanism of Hypotensive Actions of β-blockers
- Mechanisms of the Acute Hypotensive Effect of β-Adrenergic Blocking Drugs with α-Blocking Activity in Conscious SHR
- Role of the .ALPHA.-adrenergic blocking effect in the acute hypotensive effect of .BETA.-adrenergic blocking drugs with .ALPHA.-blocking activities in conscious SHR.
- Antagonism of hypotensive and bradycardic effects of centrally administered guanfacine by metiamide in anesthetized rabbits.
- Inhibition by thiamine tetrahydrofurfuryl disulfide (TTFD) of the arachidonic acid cascade-line activation as evidenced in the heart-lung preparation of the dog.
- Effects of Lidocaine on Ischemic Myocardial Metabolism Assessed by 31P-NMR in the Isolated Perfused Rat Heart.
- Ventricular pressure-heart rate product before induction of ischemia as a determinant of the reperfusion-induced accumulation of calcium within myocardium.
- Functional and metabolic effects of cardioplegia induced by a young's solution (YNG solution) as assessed in isolated atrial preparations and in isolated perfused heart preparations of the guinea pig.
- Effects of etafenone on myocardial energy metabolism as studied by an organ redoximeter and biochemical analyses.
- The sequence and correlation of the changes in several parameters of energy metabolism induced by ischemic insult in heart muscle.
- Hemodynamic Effects of Benazeprilat in the Anesthetized Dog with Acute Left Ventricular Failure.
- .ALPHA.-Blockade and vasodilatation induced by nipradilol, arotinolol and labetalol in pithed rats.
- Sarcolemmal (Ca2++Mg2+)-ATPase of vascular smooth muscle and the effects of protein kinases thereupon.