Effects of Lidocaine and Procaine on the Action Potential of Canine Sinus Nodal Cells
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概要
- 論文の詳細を見る
Effects of local anesthetics (lidocaine and procaine) on the canine sinus node were studied using isolated right atrial preparations which were obtained from puppies and perfused with oxygenated Tyrode solution through the dorsal right atrial artery. Action potential of the sinus nodal area which was characterized by the slow rate of phase 0 and diastolic depolarization, was recorded using the conventional microelectrode technique, simultaneously with atrial contraction. Lidocaine (10-300μg) prolonged the cycle length and duration of action potential, decreased the rate of phase 4 depolarization and amplitude of action potential, and shifted the threshold potential and maximal diastolic potential to the depolarizing direction. The atrial contraction decreased simultaneously. In higher doses, sinoatrial block was occasionally observed in 8 of 55 experiments. Procaine (10-300μg) had similar negative chronotropic and inotropic effects and induced sinoatrial block in 7 of 57 experiments, but unlike lidocaine, procaine produced positive chronotropic and inotropic effects following the initial negative responses in 16 of 57 experiments. The sinus node acceleration was accompanied by an increase in the rate of phase 4 depolarization. Chronotropic changes of the sinus nodal cells by these drugs were accompanied by the changes in both the rate of phase 4 depolarization and duration of the action potential
- International Heart Journal刊行会の論文
著者
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Nakajima Tamio
First Department Of Internal Medicine Nara Medical University
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Imai Shoichi
Department Of Phamacology Niigata University School Of Medicine
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Satoh Hiroyasu
Department Of Pharmacology Yamanashi Medical College
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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SATOH Hiroyasu
First Department of Oral Surgery, Niigata University School of Dentistry
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HASHIMOTO Keitaro
Department of Phamacology, Yamanashi Medical University
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