Treatment With Recombinant Placental Growth Factor (PlGF) Enhances Both Angiogenesis and Arteriogenesis and Improves Survival After Myocardial Infarction
スポンサーリンク
概要
- 論文の詳細を見る
Background: Placental growth factor (PlGF), a homolog of vascular endothelial growth factor, is reported to stimulate angiogenesis and arteriogenesis in pathological conditions. It was recently demonstrated that PlGF is rapidly produced in myocardial tissue during acute myocardial infarction (MI). However, the effects of exogenous PlGF administration on the healing process after MI are not fully understood. The purpose of the present study was to examine whether PlGF treatment has therapeutic potential in MI. Methods and Results: Recombinant human PlGF (rhPlGF: 10 μg) was administered continuously for 3 days in a mouse model of acute MI. rhPlGF treatment significantly improved survival rate after MI and preserved cardiac function relative to control mice. The numbers of CD31-positive cells and α-smooth muscle actin-positive vessels in the infarct area were significantly increased in the rhPlGF group. Endothelial progenitor cells (Flk-1+Sca-1+ cells) were mobilized by rhPlGF into the peripheral circulation. Furthermore, rhPlGF promoted the recruitment of GFP-labeled bone marrow cells to the infarct area, but only a few of those migrating cells differentiated into endothelial cells. Conclusions: Exogenous PlGF plays an important role in healing processes by improving cardiac function and stimulating angiogenesis following MI. It can be considered as a new therapeutic molecule.
- 社団法人 日本循環器学会の論文
- 2009-08-20
著者
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SAITO Yasushi
Chiba University
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Iwama Hajime
First Department of Medicine, Nara Medixal University
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Uemura Shiro
First Department of Medicine, Nara Medixal University
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Takemoto Yasuhiro
First Department of Medicine, Nara Medixal University
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Onoue Kenji
First Department of Medicine, Nara Medixal University
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Okayama Satoshi
First Department of Medicine, Nara Medixal University
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Somekawa Satoshi
First Department of Medicine, Nara Medixal University
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Takeda Yukiji
First Department of Medicine, Nara Medixal University
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Kawata Hiroyuki
First Department of Medicine, Nara Medixal University
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Horii Manabu
First Department of Medicine, Nara Medixal University
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Nakajima Tamio
First Department of Medicine, Nara Medixal University
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Saito Yoshihiko
First Department of Medicine, Nara Medixal University
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Kubo Atsushi
First Department of Internal Medicine, Nara Medical University
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UMEMURA Satoshi
Yokohama City University
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Umemura S
University Of The Ryukyus
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Saito Y
Chiba University
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SUZUKI Yoshihiko
Suzuki clinic
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ISHIGAMI Ken-ichi
First Department of Medicine, Nara Medical University
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SOEDA Tsunenari
First Department of Medicine, Nara Medical University
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NISHIDA Taku
First Department of Medicine, Nara Medical University
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IMAGAWA Kei-ichi
First Department of Internal Medicine, Nara Medical University
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TAKAOKA Minoru
First Department of Internal Medicine, Nara Medical University
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Yoshida S
Chiba University
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Saito Y
Division Of Cardiovascular Medicine Kumamoto University Graduate School Of Medical Sciences
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Soeda Tsunenari
First Department Of Internal Medicine Nara Medical University
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Saito Y
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Yamashita Shizuya
大阪大学 医学系研究科循環器内科学
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Kishimoto Ichiro
First Department Of Internal Medicine Nara Medical University
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Nishida Taku
First Department Of Internal Medicine Nara Medical University
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Takaoka Minoru
First Department Of Internal Medicine Nara Medical University
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Okayama Satoshi
First Department Of Internal Medicine Nara Medical University
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Uemura Shiro
First Department Of Internal Medicine Nara Medical University
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Iwama Hajime
First Department Of Internal Medicine Nara Medical University
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Saito Yoshihiko
Department Of Clinical Cell Biology Chiba University Graduate School Of Medicine
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Kawata Hiroyuki
First Department Of Internal Medicine Nara Medical University
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Nakajima Tamio
First Department Of Medicine Nara Medical University
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Nakashima Takao
First Department Of Internal Medicine Nara Medical University
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Nakajima Tamio
First Department Of Internal Medicine Nara Medical University
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Somekawa Satoshi
First Department Of Internal Medicine Nara Medical University
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Horii Manabu
First Department Of Medicine Nara Medical University
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Horii Manabu
First Department Of Internal Medicine Nara Medical University
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Onoue Kennji
First Department Of Internal Medicine Nara Medical University
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Takeda Yukiji
First Department Of Internal Medicine Nara Medical University
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Tomoda Yoshio
First Department Of Internal Medicine Nara Medical University
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Umemura Satoshi
日本大学 医学部内科学系腎臓高血圧内分泌内科
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Umemura Satoshi
横浜市立大学 医学研究科病態制御内科学
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Umemura S
Department Of Internal Medicine And Cardiorenal Medicine Yokohama City University Graduate School Of
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Uemura Shiro
First Department Of Medicine Nara Medical University
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Takemoto Yasuhiro
First Department Of Internal Medicine Nara Medical University
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Uchiyama Shinichiro
Department Of Neurology Tokyo Women's Medical University
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Kido Atsumichi
First Department Of Internal Medicine Nara Medical University
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Yoshida Shigeaki
国立がんセンター東病院 消化管内科
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Seino Yoshihiko
Department Of Internal Medicine Cardiovascular Center Nippon Medical School Chiba-hokusoh Hospital
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Sudo Y
Suzuki Clinic
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Umemura Satoshi
Department Of Neurology Tokyo Women's Medical University
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Kido Atsumichi
Department Of Cardiology Nantan General Hospital
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Umemura Satoshi
Department Of Medicine Yokohama City University School Of Medicine
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SASAKI Yasutsuna
National Cancer Center Hospital East
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Umemura Satoshi
Department Of Medical Science And Cardiorenal Medicine Yokohama City University School Of Medicine
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Saito Yoshihiko
First Department Of Internal Medicine Nara Medical University
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Sudo Yoshikazu
京都府立医科大学 第2内科
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Umemura Satoshi
横浜市立大学附属市民総合医療センター心臓血管センター
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Soeda Tsunenari
First Department Of Medicine Nara Medical University
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Saitou Yoshihiko
First Department Of Medicine Nara Medical University
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Saito Yoshiro
Division Of Gastrointestinal Oncology National Cancer Center Hospital
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Ueda Shinichiro
Department Of Clinical Pharmacology And Therapeutics University Of The Ryukyus School Of Medicine
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Yahagi Naohisa
Department Of Internal Medicine The University Of Tokyo
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Saito Yoshiro
Division Of Biochemistry And Immunochemistry National Institute Of Health Sciences
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Yamamoto S
Biometric Research Section Statistics And Cancer Control Division Research Center For Cancer Prevent
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Yamamoto Seiichiro
Clinical Trials And Practice Support Division Center For Cancer Control And Information Services Nat
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Umemura Satoshi
Department Of Second Internal Medicine Yokohama City University School Of Medicine
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Yoshida Shigeaki
Division Of Digestive Endoscopy And Gastrointestinal Oncology National Cancer Center Hospital East
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Kinoshita Hideyuki
Department Of Medicine And Clinical Science Endocrinology And Metabolism Kyoto University Graduate S
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Kubo Atsushi
First Department Of Internal Medicine Nara Medical University
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Uemura Shirou
First Department Of Internal Medicine Nara Medical University
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Sugio Y
Kyushu Univ. Fukuoka Jpn
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Sudo Yoshikazu
The Second Department Of Medicine Kyoto Prefectural University Of Medicine
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Saitoh Yoshihiko
The Department Of Medicine And Clinical Science Kyoto University Graduate School Of Medicine
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Shinomura Yasuhisa
Cardiovascular Medicine Department Of Internal Medicine Osaka University Graduate School Of Medicine
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Umemura S
Department Of Second Internal Medicine Yokohama City University School Of Medicine
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Nakajima Tamio
The First Department Of Internal Medicine Nara Medical University
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Umemura Satoshi
Department Of Internal Medicine Ii Yokohama City University School Of Medicine
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Suzuki Yuhsuke
Division Of Nephrology Department Of Internal Medicine Juntendo University School Of Medicine
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Yamashita Shizuya
Department Of Clinical Cell Biology Graduate School Of Medicine Chiba University
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Saito Y
Division Of Biochemistry And Immunochemistry National Institute Of Health Sciences
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Sakurai Yoshihiko
First Department Of Medicine Nara Medical University
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Yamashita Shizuya
Department Of Cardiovascular Medicine Juntendo University School Of Medicine
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Umemura Satoshi
The Second Department Of Internal Medicine Yokohama City University Yokohama
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Yoshida Sho
Department Of Internal Medicine Komagome Hospital
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Saito Yasushi
Department Of Clinical Cell Biology Chiba University Graduate School Fo Medicine
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Nakashima Takao
Department Of Cardiology Hirai Hospital
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Uemura Shiro
1st Dept. Of Int. Med. Nara Medical University
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