ON THE HISTAMINE RECEPTOR OF THE CANINE MYOCARDIUM AND CORONARY VASCULATURE
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概要
- 論文の詳細を見る
To indentify the histamine-receptors in the canine myocardium, experiments were performed in the canine heart-lung preparation supported by a donor. Smaller doses of histamine produced only an increase in the coronary blood flow. Positive inotropic and chronotropic effects appeared with larger doses. The increase in the coronary blood flow was associated with only a minimal increase in the myocardial oxygen consumption. Pretreatment of the preparation with a prototype H<SUB>1</SUB>-receptor antagonist, mepyramine, resulted in an abolishment of the positive chronotropic effect and a partial inhibition of the coronary vasodilatatory effect, indicating that the histamine-receptors in the dog atrium subserving the chronotropic effect are to be classified as H<SUB>1</SUB>-type. After a representative H<SUB>2</SUB>-receptor antagonist, metiamide, the positive chronotropic effect remained unaffected, while there was a partial inhibition of the coronary vasodilatatory effect. A combined use of both the H<SUB>1</SUB>- and H<SUB>2</SUB>-receptor antagonists brought about a complete suppression of the positive inotropic and the coronary vasodilatatory effects of histamine. These findings indicate that the histamine-receptors in the coronary vasculature belong to the same type of receptors as those in the peripheral blood vessels, and that those in the canine ventricular myocardium cannot be classified either as H<SUB>1</SUB> or H<SUB>2</SUB>.
- 社団法人 日本薬理学会の論文
著者
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Nakazawa Mikio
Department of Medical Technology, School of Health Sciences, Faculty of Medicine, Niigata University
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HASHIMOTO Keitaro
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, Universit
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Hashimoto Toyozo
Department of Cardiology, Jichi Medical School
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IMAI Shoichi
Department of Pharmacology, Niigata University School of Medicine
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Imai Shoichi
Department Of Phamacology Niigata University School Of Medicine
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Nakazawa Mikio
Departement Of Medical Technology School Of Health Sciences Faculty Of Medicine Niigata University
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NAKAGAWA YOSHITO
Department of Pharmacy, Yamagata University Hospital
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Katano Yumi
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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TAKEDA Keisuke
Department of Applied Chemistry, Faculty of Engineering, Gunma University
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TSUKADA TOKUMASA
Department of Pharmacology, Niigata University School of Medicine
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OTORII Takeshi
Department of Pharmacology, Niigata University School of Medicine
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Tsukada Tokumasa
Department Of Pharmacology Niigata University School Of Medicine
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Nakagawa Yoshito
Department Of Pharmacology Niigata University School Of Medicine
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Takeda Keisuke
Department Of Applied Chemistry Faculty Of Engineering Gunma University
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Otorii Takeshi
Department Of Pharmacology Niigata University Schcol Of Medicine
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Hashimoto Toyozo
Department Of Cardiology And Internal Medicine
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HASHIMOTO Keitaro
Department of Phamacology, Yamanashi Medical University
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TAKEDA Keisuke
Department of Pharmacology, Niigata University, School of Medicine
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OTORII Takeshi
Department of Pharmacology, Yamagata University, School of Medicine
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OTORII Takeshi
Department of Phamacology, Niigata University School of Medicine
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NAKAGAWA Yoshito
Department of Pharmacology, Niigata University, School of Medicine
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