A Study of Cardiovascular Function in Tsumura Suzuki Obese Diabetes, a New Model Mouse of Type 2 Diabetes
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概要
- 論文の詳細を見る
Diabetes mellitus is a well known and important risk factor for cardiovascular diseases, including heart failure. A new model of Type 2 diabetes, Tsumura Suzuki Obese Diabetes (TSOD) mice, was introduced recently into the research field of diabetes. The cardiac functions of TSOD mice were studied in comparison with Tsumura Suzuki Non Obesity (TSNO, non-diabetic control) mice, for the first time. In vivo cardiovascular functions were measured by echocardiography and cardiac catheterization at 7, 12 and 18 months old. TSOD mice had no deterioration of cardiac function despite the long-term persistence of severe obesity, hyperglycemia, hyperinsulinemia and hyperlipidemia, including high density lipoprotein (HDL)-cholesterol. No histopathological abnormalities were observed in the heart of TSOD mice, while several histological abnormalities were observed in the pancreas and kidney of TSOD mice. To investigate vascular endothelium function at 7 months old, intravenous injection of acetylcholine (ACh; 1, 3, 10 μg/kg)- and NG-nitro-L-arginine methyl ester (L-NAME; 50 mg/kg)-induced mean blood pressure (BP) changes were used. ACh decreased whereas L-NAME increased BP, and no significant differences in BP changes were observed between TSOD and TSNO mice. Moreover, ACh-induced relaxation of the thoracic aortae isolated from TSOD and TSNO mice with intact endothelium were not significantly different. These findings suggest that vascular endothelial cells in TSOD mice are not impaired. It was clearly demonstrated that despite obvious diabetes, cardiac functions of TSOD mice were not impaired even at 18 months old.
- 日本薬学会の論文
著者
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Sanzen Yoshiki
Department of Medical Technology, School of Health Sciences, Faculty of Medicine, Niigata University
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Ito Minami
Department of Medical Technology, School of Health Sciences, Faculty of Medicine, Niigata University
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Nakazawa Mikio
Department of Medical Technology, School of Health Sciences, Faculty of Medicine, Niigata University
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Shimada Tsutomu
Research Institute Of Pharmaceutical Sciences Musashino University
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ABURADA Masaki
Research Division, Tsumura & Co.
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IIZUKA Seiichi
Research Division, Tsumura & Co.
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SUZUKI Wataru
Research Division, Tsumura & Co.
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Kawada Tomie
Res. Inst. Of Pharmaceutical Sciences Musashino Univ.
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Kawada Tomie
Research Institute of Pharmaceutical Sciences, Musashino University
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Miyata Shigeo
Research Institute of Pharmaceutical Sciences, Musashino University
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Hemmi Chieko
Research Institute of Pharmaceutical Sciences, Musashino University
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Mihara Kiyoshi
Research Institute of Pharmaceutical Sciences, Musashino University
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Shimada Tsutomu
Res. Inst. Of Pharmaceutical Sciences Musashino Univ.
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Nakazawa Mikio
Departement Of Medical Technology School Of Health Sciences Faculty Of Medicine Niigata University
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Kawada Tomie
Research Institute Of Pharmaceutical Sciences Musashino University
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IIZUKA Seiichi
Research Institute of Pharmaceutical Sciences, Musashino University
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Aburada Masaki
Research Institute of Pharmaceutical Sciences, Musashino University
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Shimada Tsutomu
Research Institute of Pharmaceutical Sciences, Musashino University
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Ito Minami
Department of Medical Technology, School of Health Science, Faculty of Medicine, Niigata University
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Miyata Shigeo
Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University
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Suzuki Wataru
Research Institute of Pharmaceutical Sciences, Musashino University
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Sanzen Yoshiki
Department of Medical Technology, School of Health Science, Faculty of Medicine, Niigata University
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