Effect of Gomisin A (TJN-101) on the arachidonic acid cascade in macrophages.
スポンサーリンク
概要
- 論文の詳細を見る
It has been reported that leukotrienes (LTs) may play a role in inflammatory liver diseases, and several inhibitors of LTs show an inhibitory effect on experimental liver injuries. In this study, the effect of Gomisin A (TJN-101), which is a lignan component of schisandra fruits, on the arachidonic acid cascade in macrophages was examined to explain the mechanisms of the inhibitory effect of TJN-101 on liver injuries. The production of leukotriene B<SUB>4</SUB> was suppressed by treatment with TJN-101, while the activity of 5-lipoxygenase was not affected. The release of arachidonic acid from macrophages stimulated with fMet-Leu-Phe or the Ca<SUP>++</SUP>lonophore A23187 was suppressed by treatment with TJN-101. The activity of phospholipase A<SUB>2</SUB> was not affected by treatment with TJN-101. These results suggested that TJN-101 produces an inhibitory effect on the biosynthesis of LTs by preventing the release of arachidonic acid, and it was thought that the preventive effect on the arachidonic acid cascade may be partially associated with the inhibitory effect of TJN-101 on liver injuries.
- 公益社団法人 日本薬理学会の論文
著者
-
ABURADA Masaki
Research Division, Tsumura & Co.
-
HOSOYA Eikichi
Research Institute for Pharmacology, Tsumura & Co.
-
MIZOGUCHI Yasuhiro
The Third Department of Internal Medicine, Osaka City University Medical School
-
OHKURA Yasufumi
The Third Department of Internal Medicine, Osaka City University Medical School
-
MORISAWA Seiji
The First Department of Biochemistry, Osaka City University Medical School
-
TAKEDA Sigefumi
Research Institute for Pharmacology, Tsumura & Co.
-
ABURADA Masaki
Research Institute for Pharmacology, Tsumura & Co.
関連論文
- Cerebral Protective and Cognition-Improving Effects of Sinapic Acid in Rodents(Pharmacology)
- Cognitive Improving and Cerebral Protective Effects of Acylated Oligosaccharides in Polygala tenuifolia(Medicinal Chemistry)
- Antinociceptive Effect of Shakuyakukanzoto, a Kampo Medicine, in Diabetic Mice
- Diabetic Complications in a New Animal Model (TSOD mouse) of Spontaneous NIDDM with Obesity
- Structure Activity Relationships of Quinoxalin-2-one Derivatives as Platelet-Derived Growth Factor-β Receptor (PDGFβ R) Inhibitors, Derived from Molecular Modeling
- Synthesis and Evaluation of Carbamate Prodrugs of a Phenolic Compound
- Potent Platelet-Derived Growth Factor-β Receptor (PDGF-βR) Inhibitors : Synthesis and Structure-Activity Relationships of 7-[3-(Cyclohexylmethyl)ureido]-3-{1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl}quinoxalin-2(1H)-one Derivatives
- Indoor Cultivation and Cultural Characteristics of Wolfiporia cocos Sclerotia Using Mushroom Culture Bottles(Pharmacognosy)
- Identification of Medicinal Atractylodes Based on ITS Sequences of nrDNA(Pharmacognosy)
- Synthesis of a Capillarisin Sulfur-Analogue Possessing Aldose Reductase Inhibitory Activity by Selective Isopropylation
- A Study of Cardiovascular Function in Tsumura Suzuki Obese Diabetes, a New Model Mouse of Type 2 Diabetes
- Preventive Effects of Bofutsushosan on Obesity and Various Metabolic Disorders(Pharmacology)
- Efficacy of Tokishakuyakusan on the Anemia in the Iron-Deficient Pregnant Rats(Biopharmacy)
- Pharmacokinetics of [6]-shogaol, a pungent ingredient of Zingiber officinale Roscoe (Part I)
- Metabolic disease prevention and suppression of fat accumulation by Salacia reticulata
- Isolation of 8'-Phosphate Ester Derivatives of Amicoumacins : Structure-activity Relationship of Hydroxy Amino Acid Moiety
- AUTOMATIC MONITORING SYSTEM FOR THE MEASUREMENT OF BODY WEIGHT, FOOD AND WATER CONSUMPTION AND SPONTANEOUS ACTIVITY OF A MOUSE
- Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetic mice
- Preventive Effect of Geniposide on Metabolic Disease Status in Spontaneously Obese Type 2 Diabetic Mice and Free Fatty Acid-Treated HepG2 Cells
- Polymethoxyflavonoids from Kaempferia parviflora Induce Adipogenesis on 3T3-L1 Preadipocytes by Regulating Transcription Factors at an Early Stage of Differentiation
- Tetrandrine Prevents Bone Loss in Sciatic-Neurectomized Mice and Inhibits Receptor Activator of Nuclear Factor κB Ligand-Induced Osteoclast Differentiation
- Puerariae flos alleviates metabolic diseases in Western diet-loaded, spontaneously obese type 2 diabetic model mice
- Inhibitory effect of TJN-101 ((+)-(6S,7S,R-Biar)-5,6,7,8-tetrahydro-1,2,3,12-tetramethoxy-6,7-dimethyl-10,11-methylenedioxy-6-dibenzo(a,c)cyclooctenol) on immunologically induced liver injuries.
- Effect of Gomisin A (TJN-101) on the arachidonic acid cascade in macrophages.