Antinociceptive Effect of Shakuyakukanzoto, a Kampo Medicine, in Diabetic Mice
スポンサーリンク
概要
- 論文の詳細を見る
In this study, the antinociceptive effect of shakuyakukanzoto was investigated using streptozotocin-induced diabetic mice to certify its analgesic effect on diabetic patients. Shakuyakukanzoto (0.5 and 1.0 g/kg, p.o.) significantly increased the nociceptive threshold in diabetic mice. The antinociceptive activity of shakuyakukanzoto in diabetic mice was not antagonized by β-funaltrexamine, naltrindole, or nor-binaltorphimine. The increased antinociceptive activity of (1.0 g/kg, p.o.) in diabetic mice was abolished by yohimbine (15 μg, i.t.), but not by NAN-190 (1 μg, i.t.), methysergide (15 μg, i.t.), or MDL-72222 (15 μg, i.t.). In shakuyakukanzoto diabetic mice treated with 6-hydroxydopamine (20 μg, i.t.) chemically lesioned noradrenergic pathways, shakuyakukanzoto (1.0 g/kg, p.o.) failed to exhibit an antinociceptive effect. Furthermore, the antinociceptive activity induced by norepinephrine (0.06 – 2 μg, i.t.) was markedly more potent in diabetic mice than in non-diabetic mice at the same dose. These results suggest that the antinociceptive effect of shakuyakukanzoto in diabetic mice is not mediated by the opioid systems and that this effect appears via selective activation of the spinal descending inhibitory α2-adrenergic systems without activating the serotonergic systems. The spinal α2-adrenoceptor-mediated analgesic mechanism was enhanced in diabetic mice, suggesting that shakuyakukanzoto exhibits its effect by activating the descending noradrenergic neurons.
- 社団法人 日本薬理学会の論文
- 2005-12-20
著者
-
ABURADA Masaki
Research Division, Tsumura & Co.
-
油田 正樹
Res. Inst. Of Pharmaceutical Sciences Musashino Univ.
-
油田 正樹
Medicinal Evaluation Laboratory Tsumura Research Institute
-
Kase Y
Tsumura Research Laboratories Tsumura & Co.
-
Kase Yoshio
ツムラ漢方生薬研究所
-
Kase Yoshio
国立長寿医療センター研究所 老年病研究部
-
Kase Yoshio
Central Research Laboratories Tsumura & Co.
-
Kase Yoshio
Central Research Laboratory Tsumura & Co.
-
Aburada M
Fac. Of Pharmacy Musashino Univ.
-
Aburada M
Tsumura Research Inst. Pharmacology Ibaraki Jpn
-
加瀬 義夫
津村薬理研究所
-
TAKEDA Shuichi
Central Research Laboratories, Tsumura & Co.
-
OMIYA Yuji
Central Research Laboratories, Tsumura & Co.
-
SUZUKI Yasuyuki
Central Research Laboratories, Tsumura & Co.
-
YUZURIHARA Mitsutoshi
Central Research Laboratories, Tsumura & Co.
-
MURATA Mikio
Toumeiatsugi Hospital
-
Yuzurihara Mitsutoshi
Tsumura Research Laboratories Tsumura & Co.
-
Yuzurihara M
Tsumura Res. Inst. Medical Evaluation Lab. Ibaraki Jpn
-
Yuzurihara Mitsutoshi
Central Research Laboratory Tsumura & Co.
-
Yuzurihara Mitsutoshi
Kampo & Parmacognosy Laboratory Tsumura & Co.
-
竹田 秀一
Tsumura & Co. Tsumura Res. Laboratories
-
油田 正樹
ツムラ研究本部 医薬評価研究所
-
Mizuhara Yasuharu
Medicinal Evaluation Laboratory Tsumura & Co.:department Of Medicinal Informatics Graduate Schoo
-
Kase Yoshio
ツムラツムラ研究所
-
Takeda Shuichi
Central Research Laboratories Tsumura & Co.
-
Aburada Masaki
Musashino Univ. Tokyo Jpn
-
Omiya Yuji
Central Research Laboratories Tsumura & Co.
-
Suzuki Yasuyuki
Central Research Laboratories Tsumura & Co.
関連論文
- 炭酸ガス含有無機塩浴の効果 : 体温、体循環と食物吸収
- 2G178 El-マウス神経細胞の特色
- Cerebral Protective and Cognition-Improving Effects of Sinapic Acid in Rodents(Pharmacology)
- Cognitive Improving and Cerebral Protective Effects of Acylated Oligosaccharides in Polygala tenuifolia(Medicinal Chemistry)
- APP-Tgマウスの学習障害と周辺症状に対する抑肝散の効果
- チアミン欠乏マウスの社会的行動性低下および攻撃性増加に対する抑肝散の改善効果
- 抑肝散のパラクロロアンフェタミン誘発攻撃行動に対する改善作用
- モルモット単離胃におけるgastric adaptive relaxationについての検討
- I-A-23 十全大補湯の免疫調節活性に対する構成生薬の影響
- Gomisin A(TJN-101)の体内動態に関する研究(第1報)ラットにおける吸収
- Studies on the Metabolism of Gomisin A (TJN-101). I. : Oxidative Products of Gomisin A Formed by Rat Liver S9 Mix.
- General Pharmacological Properties of Dai-kenchu-to Extract
- General Pharmacological Properties of Daio-kanzo-to
- General Pharmacological Properties of Juzen-taiho-to
- General Pharmacological Properties of Hochu-ekki-to
- General Pharmacological Properties of Shakuyaku-kanzo-to
- Effects of Gomisin A on the Promotor Action and Serum Bile Acid Concentration in Hepatocarcinogenesis Induced by 3'-Methyl-4-dimethylamino-azobenzene
- Inhibition by Gomisin A, a Lignan Compound, of Hepatocarcinogenesis by 3'-Methyl-4-dimethylaminoazobenzene in Rats
- 生薬配合外用剤の男性型脱毛症に対する使用試験
- 演題3 大建中湯の消化管運動機能改善作用(第8回小児外科漢方研究会(第40回日本小児外科学会総会ランチョンセミナー))
- E-039(31) 柴苓湯の尿排泄調節作用
- GnRHアナログを処置した雄性ラットのCGRP誘発皮膚温上昇に対する桂枝茯苓丸の抑制作用
- General Pharmacological Properties of Choto-san extracts
- ガスクロマトグラフ質量分析計によるラット血清中のGomisin A (TJN-101) 及び代謝物の定量
- Gomisin A(TJN-101)の体内動態に関する研究(第2報)四塩化炭素肝障害ラットにおける吸収及び排泄
- I-D-19 蒼朮中精油成分β-eudesmol に関する鼻粘膜吸収性
- 五味子成分Gomisin J並びに類縁リグナン類化合物の摘出臓器平滑筋に対する作用
- 五味子リグナン成分(+)-(6S, 7S, R-Biar)-5,6,7,8-tetrahydro-1,2,3,12-tetramethoxy-6,7-dimethyl-10,11-methylenedioxy-6-dibenzo[a, c]cyclooctenol(TJN-101)の肝障害抑制作用に関する研究.実験的急性肝障害における溶解補助剤の差異による効果の変動
- 喘息ストレスは脳ヒスタミンH_1受容体の Up-regulation を誘発する
- Synephrine, a Component of Evodiae Fructus, Constricts Isolated Rat Aorta via Adrenergic and Serotonergic Receptors
- Goshuyuto, a Traditional Japanese Medicine, and Aqueous Extracts of Evodiae Fructus Constrict Isolated Rat Aorta via Adrenergic and/or Serotonergic Receptors(Pharmacology)
- Goshuyuto, a Traditional Japanese Medicine for Migraine, Inhibits Platelet Aggregation in Guinea-Pig Whole Blood
- An Herbal Medicine Orengedokuto Prevents Indomethacin-Induced Enteropathy(Pharmacology)
- Effects of Saireito, a Japanese herbal medicine, on edema via antagonistic actions against aldosterone in anti-GBM nephritic rats
- Pharmacokinetics of (-)Epicatechin 3-O-Gallate, Glycyrrhetic Acid and Rhein in Healthy Male Volunteers after Multiple Dose Administration of TJ-8117 (Unipito), a Japanese Traditional Medicine for Renal Failure
- Pharmacokinetics of (-)Epicatechin 3-O-Gallate, Glycyrrhetic Acid and Rhein in Healthy Male Volunteers after a Single Dose Administration of TJ-8117 (Unpito), a Japanese Traditional Medicine for Renal Failure
- Antinociceptive Effect of Shakuyakukanzoto, a Kampo Medicine, in Diabetic Mice
- Glycyrrhizin induced hypokaliemia in laboratory animal(Endocrine system, Proceedings of the 32nd Annual Meeting)
- The influence of the sennosides on absorption of glycyrrhetic acid in rats
- Effects of Rikkunshi-to, a Traditional Japanese Medicine, on the Delay of Gastric Emptying Induced by N^G-Nitro-L-arginine
- Antianginal Effects of Lercanidipine on the Vasopressin or Methacholine Induced Anginal Model in Rats(Pharmacology)
- Diabetic Complications in a New Animal Model (TSOD mouse) of Spontaneous NIDDM with Obesity
- Effects of Rikkunshi-to, a Traditional Japanese Medicine, on the Delay of Gastric Emptying Induced by NG-Nitro-L-arginine
- Effect of Sairei-to on signal transduction of the vasopressin V2 receptor in rat renal cortex
- Effects of 17β-Estradiol and the Japanese Herbal Medicine Keishi-bukuryo-gan on the Release and Synthesis of Calcitonin Gene-RelatedPeptide in Ovariectomized Rats
- Pharmacological Characteristics of Ryokan-Kyomi-shinge-nin-to, an Antiallergic Kampo Medicine
- Pharmacological Evaluation of Shokyo and Kankyo (1)
- Dai-kenchu-to Enhances Accelerated Small Intestinal Movement
- Structure Activity Relationships of Quinoxalin-2-one Derivatives as Platelet-Derived Growth Factor-β Receptor (PDGFβ R) Inhibitors, Derived from Molecular Modeling
- Convenient synthetic method for 3-(3-substituted indol-2-yl)quinoxalin-2- ones as VEGF inhibitor
- Synthesis and Evaluation of Carbamate Prodrugs of a Phenolic Compound
- Potent Platelet-Derived Growth Factor-β Receptor (PDGF-βR) Inhibitors : Synthesis and Structure-Activity Relationships of 7-[3-(Cyclohexylmethyl)ureido]-3-{1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl}quinoxalin-2(1H)-one Derivatives
- Indoor Cultivation and Cultural Characteristics of Wolfiporia cocos Sclerotia Using Mushroom Culture Bottles(Pharmacognosy)
- Monosodium glutamateによって誘発された肥満マウスの2型糖尿病の特徴
- Identification of Medicinal Atractylodes Based on ITS Sequences of nrDNA(Pharmacognosy)
- Synthesis of a Capillarisin Sulfur-Analogue Possessing Aldose Reductase Inhibitory Activity by Selective Isopropylation
- Molecular Identification of Tiandong(天冬) Derived from Asparagus cochinchinensis(Lour.) Merrill by Two Typical Deletions in cpDNA
- Separation and isolation methods for analysis of the active principles of Sho-saiko-to (SST) oriental medicine
- The Diuretic Effect of Sairei-to Is Mediated by Nitric Oxide Production in Pentobarbital-Anesthetized Rats
- Structure Determination of Biliary Metabolites of Schizandrin in Rat and Dog
- Pharmacological Studies of the Effect of Dai-kenchu-to on Spontaneous Contraction of Isolated Rabbit Jejunum
- Effects of Dai-kenchu-to on Intestinal Obstruction Following Laparotomy
- Effects of Keishi-ka-shakuyaku-to (Gui-Zhi-Jia-Shao-Yao-Tang) on Diarrhea and Small Intestinal Movement
- Effects of Hange-shashin-to on Cholera Toxin-Induced Fluid Secretion in the Small Intestine of Rats
- The Effects of Hange-shashin-to on the Content of Prostaglandin E_2 and Water Absorption in the Large Intestine of Rats
- Pharmacological Studies on Antidiarrheal Effects of Hange-Shashin-To
- 甘草の抗潰瘍作用本体の解明
- A Study of Cardiovascular Function in Tsumura Suzuki Obese Diabetes, a New Model Mouse of Type 2 Diabetes
- Preventive Effects of Bofutsushosan on Obesity and Various Metabolic Disorders(Pharmacology)
- Efficacy of Tokishakuyakusan on the Anemia in the Iron-Deficient Pregnant Rats(Biopharmacy)
- Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced anxiety in rats : comparison with diazepam
- The Pharmacological Effects of Daikenchuto, a Traditional Herbal Medicine, on Delayed Gastrointestinal Transit in Rat Postoperative Ileus
- PHARMACOLOGICAL STUDIES ON GINGER. III. EFFECT OF THE SPINAL DESTRUCTION ON (6)-SHOGAOL-INDUCED PRESSOR RESPONSE IN RATS
- PHARMACOLOGICAL STUDIES ON GINGER. II. PRESSOR ACTION OF (6)-SHOGAOL IN ANESTHETIZED RATS, OR HINDQUARTERS, TAIL AND MESENTERIC VASCULAR BEDS OF RATS
- PHARMACOLOGICAL STUDIES ON GINGER. I. PHARMACOLOGICAL ACTIONS OF PUNGENT CONSTITUENTS, (6)-GINGEROL AND (6)-SHOGAOL
- Mechanisms by Which Hange-shashin-to Reduces Prostaglandin E2 Levels
- The Effects of Hange-shashin-to on Gastric Function in Comparison with Sho-saiko-to
- Pharmacokinetics of Rhein from Onpi-to, an Oriental Herbal Medicine, in Rats
- Pharmacokinetics of (-)-Epicatechin-3-0-gallate, an Active Component of Onpi-to, in Rats
- Preventive Effects of Hange-shashin-to on Irinotecan Hydrochloride-Caused Diarrhea and Its Relevance to the Colonic Prostaglandin E_2 and Water Absorption in the Rat
- The Effect of Herbal Medicine Toki-shakuyaku-san on Blood Pressure in an N^ω-Nitro-L-Arginine Methyl Ester-Induced Pre-eclampsia Rat Model During Pregnancy and the Postpartum Period
- Saireito probably prevents mesangial cell proliferation in HIGA mice via PDGF-BB tyrosine kinase inhibition
- Relevance of Irinotecan Hydrochloride-Induced Diarrhea to the Level of Prostaglandin E_2 and Water Absorption of Large Intestine in Rats
- Pharmacokinetics of [6]-shogaol, a pungent ingredient of Zingiber officinale Roscoe (Part I)
- Simultaneous determination of byak-angelicin and oxypeucedanin hydrate in rat plasma by column-switching high-performance liquid chromatography with ultraviolet detection
- Metabolic disease prevention and suppression of fat accumulation by Salacia reticulata
- Isolation of 8'-Phosphate Ester Derivatives of Amicoumacins : Structure-activity Relationship of Hydroxy Amino Acid Moiety
- AUTOMATIC MONITORING SYSTEM FOR THE MEASUREMENT OF BODY WEIGHT, FOOD AND WATER CONSUMPTION AND SPONTANEOUS ACTIVITY OF A MOUSE
- Effects of TJN-598, a new selective phosphodiesterase type IV inhibitor on anti-Thy1 nephritis in rats
- 五味子の薬理学的研究(第3報) : ラット実験的肝障害に対する五味子リグナン成分Wuweizisu Cの作用
- 甘草の抗潰瘍作用本体の解明
- Discrimination of Maidong (麦冬) Derived from Ophiopogon and Liriope Species by rbcL Sequences, and Their Chemical Components and Tuber Anatomy
- Molecular Identification of Tiandong(天冬) Derived from Asparagus cochinchinensis(Lour.) Merrill by Two Typical Deletions in cpDNA
- Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetic mice
- Preventive Effect of Geniposide on Metabolic Disease Status in Spontaneously Obese Type 2 Diabetic Mice and Free Fatty Acid-Treated HepG2 Cells
- Possible Involvement of the Transient Receptor Potential Vanilloid Type 1 Channel in Postoperative Adhesive Obstruction and Its Prevention by a Kampo (Traditional Japanese) Medicine, Daikenchuto
- Polymethoxyflavonoids from Kaempferia parviflora Induce Adipogenesis on 3T3-L1 Preadipocytes by Regulating Transcription Factors at an Early Stage of Differentiation
- Tetrandrine Prevents Bone Loss in Sciatic-Neurectomized Mice and Inhibits Receptor Activator of Nuclear Factor κB Ligand-Induced Osteoclast Differentiation
- Puerariae flos alleviates metabolic diseases in Western diet-loaded, spontaneously obese type 2 diabetic model mice
- Effect of Gomisin A (TJN-101) on the arachidonic acid cascade in macrophages.