The Effects of Hange-shashin-to on Gastric Function in Comparison with Sho-saiko-to
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概要
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The effects of "Hange-shashin-to (TJ-14)" on gastric function were examined in comparison with "Sho-saiko-to (TJ-9)". Oral treatment with TJ-14 (125-500 mg/kg) caused dose-dependent suppression of ethanol-induced gastric injury, while it did not suppress gastric lesions induced by water-immersion stress. TJ-9 (125-500 mg/kg, p.o.) suppressed both water-immersion stress-induced gastric lesions and ethanol-induced gastric injury in a dose-dependent manner. Intraduodenal administration of TJ-14 even at 500 mg/kg did not affect gastric juice secretion, while TJ-9 at 125 to 500 mg/kg dose-dependently suppressed gastric juice secretion. TJ-14 (125-500 mg/kg, p.o.) accelerated gastric emptying in normal rats and improved the delayed gastric emptying induced by BaCl_2 in a dose-dependent manner, whereas such effect was not noted with TJ-9. Oral treatment with TJ-14 at 500 mg/kg significantly suppressed apomorphine-induced vomiting, but it did not affect copper sulfate-induced vomiting. These results suggest that TJ-14 exhibits an anti-ulcer action (probably based on its ability to protect the gastric mucosa), improvement of gastric emptying and an anti-emetic action. TJ-9 also showed anti-ulcer effects, probably based on its ability to suppress gastric secretion and to protect the gastric mucosa.Thus, the present study demonstrated the effectiveness of TJ-14 and TJ-9 against disease, and provided basic data which explain the differences in clinical application between these two kampo medicines.
- 公益社団法人日本薬学会の論文
- 1997-11-15
著者
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石毛 敦
株式会社ツムラ 研究本部 医薬評価研究所
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石毛 敦
ツムラ研究本部 医薬評価研究所
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Kase Yoshio
国立長寿医療センター研究所 老年病研究部
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Kase Yoshio
Central Research Laboratories Tsumura & Co.
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Kase Yoshio
Central Research Laboratory Tsumura & Co.
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Ishige Atsushi
Center For Kampo Medicine Keio University School Of Medicine
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Ishige Atsushi
北陸大学 薬 薬物治療
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Ishige Atsushi
Kampo And Pharmacognosy Laboratories Tsumura & Co.
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YUZURIHARA Mitsutoshi
Central Research Laboratories, Tsumura & Co.
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Yuzurihara Mitsutoshi
Tsumura Research Laboratories Tsumura & Co.
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Yuzurihara M
Tsumura Res. Inst. Medical Evaluation Lab. Ibaraki Jpn
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Yuzurihara Mitsutoshi
Central Research Laboratory Tsumura & Co.
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Yuzurihara Mitsutoshi
Kampo & Parmacognosy Laboratory Tsumura & Co.
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KOMATSU Yasuhiro
Central Research Laboratories, Tsumura & Co.
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ISHIGE Atsusi
Central Research Laboratories, Tsumura & Co.,
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Ishige Atsushi
Kampo Pharmacology Department Ii Pharmacognosy Laboratory
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Iizuka Susumu
Central Research Laboratories Tsumura & Co.
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Komatsu Yasuhiro
Central Research Laboratories Tsumura & Co
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Mizuhara Yasuharu
Medicinal Evaluation Laboratory Tsumura & Co.:department Of Medicinal Informatics Graduate Schoo
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Iizuka A
Central Research Laboratories Tsumura & Co
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