Anti-type I Allergic Mechanisms of Mao-bushi-saishin-to in Mice
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the anti−allergic effect of mao−bushi−saishin−to(MBS)on the type I allergy model in mice.When MBS was administered orally at a dose of 0.5 or 1.0g/kg, edema of the footpad, the amount of plasma IgE and the ratio of eosinophilic leukocytes in peritoneal exudate cells were all dose−relatedly suppressed.Moreover to investigate the anti−type I allergic mechanisms of MBS, enzyme−linked immunosorbent assay was performed to determine the interleukin(IL)−4, IL−5 and interferon(IFN)−gamma production from splenocytes that were stimulated by pokeweed mitogen for 48 h.In addition, we assayed IgE production from splenic B cells stimulated with the lipopolysaccharide and IL−4 for 7 days.MBS inhibited the IL−4 and IFN−gamma production, but IL−5 and IgE production were not affected.Thus possibly, the inhibition of IL−4 production may partially be involved in the expression of the anti−type I allergic effects of MBS.
- 社団法人 日本薬理学会の論文
- 2000-01-01
著者
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Komatsu Yasuhiro
北陸大学 薬 薬物治療
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Ishige Atsushi
Center For Kampo Medicine Keio University School Of Medicine
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Ishige Atsushi
北陸大学 薬 薬物治療
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Ishige Atsushi
Kampo And Pharmacognosy Laboratories Tsumura & Co.
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ISHIGE Atsushi
Central Research Laboratories, Tsumura & Co.
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Ikeda Yoshiki
Kampo & Pharmacognosy Laboratory R & D Division Tsumura & Co.
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KOMATSU Yasuhiro
Central Research Laboratories, Tsumura & Co.
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Ishige Atsushi
Kampo Pharmacology Department Ii Pharmacognosy Laboratory
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Ishige Atsushi
Central Research Laboratories Tsumura & Co
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Komatsu Y
Tsumura Central Research Laboratories Tsumura And Co.
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Komatsu Y
Central Research Laboratories Tsumura & Co
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Komatsu Yasuhiro
Department Of Serology Kanazawa Medical University
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IIZUKA Akira
Central Research Laboratories, Tsumura & Co.
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AMAGAYA Sakae
Central Research Laboratories, Tsumura & Co.
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Komatsu Yasuhiro
Central Research Laboratories Tsumura & Co
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Komatsu Y
Kampo And Pharmacognosy Laboratories Tsumura & Co.
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Iizuka A
Central Research Laboratories Tsumura & Co
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Fujihira Eiichi
Department Of Pharmacotherapy Hokkaido College Of Pharmacy
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Amagaya S
Central Research Laboratories Tsumura & Co
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Amagaya Sakae
Central Research Laboratories Tsumura & Co.
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Amagaya Sakae
Pharmacognosy And Medicical Resources Laboratories Tsumura Research Institute Tsumura & Co.
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IKEDA Yoshiki
Central Research Laboratories, Tsumura & Co
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Ikeda Y
Kampo & Pharmacognosy Laboratory R & D Division Tsumura & Co.
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Komatsu Y
Res. Center Eishogen Co. Ltd. Saitama Jpn
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