Effects of San'o-shashin-to and the Constituent Herbal Medicines on Theophylline-Induced Increase in Arterial Blood Pressure of Rats

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概要

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• San'o-shashin-to, composed of Scutellariae Radix, Coptidis Rhizoma and Rhei Rhizoma(volume ratio=1:1:1), reduced an increase in arterial blood pressure of anesthetized rats induced by theophylline(5mg/kg, i.v.). The hypotensive effect of San'o-shashin-to was produced in a dose dependent manner and was maximum at its 0.5 g/kg. Then the constituent herbal medicines were examined for their possible hypotensive effect. Scutellariae Radix of 0.2g/kg slightly decreased in the blood presure. Rhei Rhizoma of 0.2g/kg decreased in the blood pressure and the hypotensive effect was significantly produced even at the dose of 0.05g/kg, while Coptidis Rhizoma had little effect. Among fractions of San'o-shashin-to separated by Diaion HP-20 column chromatography, the 50% methanol-eluted fraction had a large hypotensive effect. The 50% methanol-eluted fraction of Scutellariae Radix and Rhei Rhizoma were also effective and, especially, that of Rhei Rhizoma had a large hypotensive effect. In isometric tension study, Scutellariae Radix and Rhei Rhizoma(10-30 μg/ml)slightly exerted contractile and relaxant effects, respectively, on the phenylephrine-contracted endothelium-intact rat thoracic aorta. Coptidis Rhizoma(1-10μg/ml)caused both endothelium-dependent and -independent relaxantion. These results suggest that the hypotensive effect of San'o-shashin-to is not mediated by the direct action on blood vessel but by other actions. Some components in Scutellariae Radix and Rhei Rhizoma, especially in the latter may play a main role in the hypotensive effect.

• 社団法人日本薬学会の論文
• 2001-10-01

著者

• Komatsu Yasuhiro

  北陸大学 薬 薬物治療

• HAYASHI HISAO

  Department of Medicine, Faculty of Pharmaceutical Sciences, Hokuriku University

• Kido T

  Department Of Medicinal Informatics Graduate School Of Medicine Kanazawa University

• Kido Toshitaka

  Central Res. Laboratories Tsumura & Co.

• Kido T

  Tsumura & Co. Ibaraki Jpn

• SANAE Fujiko

  Department of Medicine, Faculty of Pharmaceutical Sciences, Hokuriku University

• KOMATSU Yasuhiro

  Department of Serology, Kanazawa Medical University

• CHISAKI Keigo

  Central Research Laboratories, Tsumura & Co.

• ISHIGE Atsushi

  Central Research Laboratories, Tsumura & Co.

• Sanae F

  Hokuriku Univ. Kanazawa Jpn

• Sanae Fujiko

  Third Division Of Research Department Research Laboratory For Development Of Medicine School Of Phar

• Sanae Fujiko

  Research Laboratory For Development Of Medicine School Of Pharmacy Hokuriku University

• Sanae Fujiko

  Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University

• Chisaki Keigo

  Central Research Laboratories Tsumura & Co.

• Ishige Atsushi

  Central Research Laboratories Tsumura & Co.

• Ishige Atsushi

  Central Research Laboratories Tsumura & Co

• Komatsu Y

  Tsumura Central Research Laboratories Tsumura And Co.

• Komatsu Y

  Central Research Laboratories Tsumura & Co

• Komatsu Yasuhiro

  Department Of Serology Kanazawa Medical University

• Hayashi Hisao

  Sony Corp. Research And Development Dept. Semiconductor Group

• Hayashi Hisao

  Department Of Medicine Faculty Or Pharmaceutical Sciences Hokuriku University

• Hayashi Hisao

  Department Of Medicine Faculty Of Pharmaceutical Sciences Hokuriku University

• Komatsu Y

  Kampo And Pharmacognosy Laboratories Tsumura & Co.

• Komatsu Y

  Res. Center Eishogen Co. Ltd. Saitama Jpn

• Komatsu Yasuhiro

  Department Of Electrical Engineering Tokai University

• Hayashi Hisao

  Department Of Medicine Aichi Gakuin University School Of Pharmacy

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