Studies on responsiveness of hepatoma cells to catecholamines. IV Lack of adrenergic activation of phosphorylase in rat ascites hepatoma cells.
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概要
- 論文の詳細を見る
Glycogen phosphorylase a activity in 7 rat ascites hepatoma cell lines treated with adrenergic agents, phenylephrine, epinephrine and isoproterenol, was investigated as compared with that in freshly isolated rat hepatocytes. Basal phosphorylase activities in hepatoma cells except AH7974 cells were lower than that in hepatocytes. Phosphorylase in hepatoma cells was not activated by any of the agents, while the enzyme activity in hepatocytes was clearly increased in a doseand time-dependent manner. Phosphorylase in hepatocytes was sensitive to glucagon, but it was found to be insensitive to glucagon in all hepatoma cells. The present results suggest that rat ascites hepatoma cells may escape the glycogenolytic regulation by catecholamines and glucagon.
- 公益社団法人 日本薬理学会の論文
著者
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Wakusawa Shinya
Department Of Medical Technology Nagoya University School Of Health Sciences
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Sanae Fujiko
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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KOSHIURA RYOZO
Department of Pharmacology, Hokuriku University School of Pharmacy
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Miyamoto Kenichi
Department Of Chemistry For Materials Faculty Of Engineering And Graduate School Of Engineering Mie
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YANAOKA Toshikazu
Department of Pharmacology, Hokuriku University School of Pharmacy
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